PMID- 33171539
OWN - NLM
STAT- MEDLINE
DCOM- 20220125
LR  - 20221101
IS  - 1549-8719 (Electronic)
IS  - 1073-9688 (Linking)
VI  - 28
IP  - 3
DP  - 2021 Apr
TI  - The cerebral microvasculature: Basic and clinical perspectives on stroke and 
      glioma.
PG  - e12671
LID - 10.1111/micc.12671 [doi]
AB  - Microvascular networks are vital components of the cardiovascular system, 
      performing many key roles in maintaining the health and homeostasis of the 
      tissues and organs in which they develop. As discussed in this review, the 
      molecular and cellular components within the microcirculation orchestrate 
      critical processes to establish functional capillary beds, including organization 
      of endothelial cell (EC) polarity, guiding investment of vascular pericytes 
      (PCs), and building the specialized extracellular matrix (ECM) that comprises the 
      vascular basement membrane (vBM). Herein, we further discuss the unique features 
      of the microvasculature in the central nervous system (CNS), focusing on the 
      cells contributing to the neurovascular unit (NVU) that form and maintain the 
      blood-brain barrier (BBB). With a focus on vascular PCs, we offer basic and 
      clinical perspectives on neurovascular-related pathologies that involve defects 
      within the cerebral microvasculature. Specifically, we present microvascular 
      anomalies associated with glioblastoma multiforme (GBM) including defects in 
      vascular-immune cell interactions and associated clinical therapies targeting 
      microvessels (ie, vascular-disrupting/anti-angiogenic agents and focused 
      ultrasound). We also discuss the involvement of the microcirculation in stroke 
      responses and potential therapeutic approaches. Our goal was to compare the 
      cellular and molecular changes that occur in the microvasculature and NVU, and to 
      provide a commentary on factors driving disease progression in GBM and stroke. We 
      conclude with a forward-looking perspective on the importance of microcirculation 
      research in developing clinical treatments for these devastating conditions.
CI  - (c) 2020 John Wiley & Sons Ltd.
FAU - Hoque, Maruf M
AU  - Hoque MM
AD  - Center for Heart and Reparative Medicine Research, Fralin Biomedical Research 
      Institute at Virginia Tech-Carilion, Roanoke, VA, USA.
AD  - Graduate Program in Translational Biology, Medicine and Health, Virginia Tech, 
      Blacksburg, VA, USA.
FAU - Abdelazim, Hanaa
AU  - Abdelazim H
AD  - Center for Heart and Reparative Medicine Research, Fralin Biomedical Research 
      Institute at Virginia Tech-Carilion, Roanoke, VA, USA.
AD  - Graduate Program in Translational Biology, Medicine and Health, Virginia Tech, 
      Blacksburg, VA, USA.
FAU - Jenkins-Houk, Clifton
AU  - Jenkins-Houk C
AD  - Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
FAU - Wright, Dawn
AU  - Wright D
AD  - Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
FAU - Patel, Biraj M
AU  - Patel BM
AD  - Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
AD  - Department of Radiology, Carilion Clinic, Roanoke, VA, USA.
FAU - Chappell, John C
AU  - Chappell JC
AUID- ORCID: 0000-0002-0427-5170
AD  - Center for Heart and Reparative Medicine Research, Fralin Biomedical Research 
      Institute at Virginia Tech-Carilion, Roanoke, VA, USA.
AD  - Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
AD  - Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, 
      VA, USA.
LA  - eng
GR  - R01 HL146596/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20201122
PL  - United States
TA  - Microcirculation
JT  - Microcirculation (New York, N.Y. : 1994)
JID - 9434935
SB  - IM
MH  - Blood-Brain Barrier
MH  - *Glioma
MH  - Humans
MH  - Microvessels
MH  - Pericytes
MH  - *Stroke
OTO - NOTNLM
OT  - glioblastoma
OT  - microcirculation
OT  - pericyte
OT  - stroke
EDAT- 2020/11/11 06:00
MHDA- 2022/01/27 06:00
CRDT- 2020/11/10 20:16
PHST- 2020/10/13 00:00 [revised]
PHST- 2020/07/10 00:00 [received]
PHST- 2020/11/04 00:00 [accepted]
PHST- 2020/11/11 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2020/11/10 20:16 [entrez]
AID - 10.1111/micc.12671 [doi]
PST - ppublish
SO  - Microcirculation. 2021 Apr;28(3):e12671. doi: 10.1111/micc.12671. Epub 2020 Nov 
      22.