PMID- 33171992
OWN - NLM
STAT- MEDLINE
DCOM- 20210616
LR  - 20240330
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 9
IP  - 11
DP  - 2020 Nov 6
TI  - Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or 
      Environmental Sensor.
LID - 10.3390/cells9112426 [doi]
LID - 2426
AB  - Xenobiotic nuclear receptors (NR) are intracellular players involved in an 
      increasing number of physiological processes. Examined and characterized in 
      peripheral organs where they govern metabolic, transport and detoxification 
      mechanisms, accumulating data suggest a functional expression of specific NR at 
      the neurovascular unit (NVU). Here, we focus on the Constitutive Androstane 
      Receptor (CAR), expressed in detoxifying organs such as the liver, intestines and 
      kidneys. By direct and indirect activation, CAR is implicated in hepatic 
      detoxification of xenobiotics, environmental contaminants, and endogenous 
      molecules (bilirubin, bile acids). Importantly, CAR participates in physiological 
      stress adaptation responses, hormonal and energy homeostasis due to glucose and 
      lipid sensing. We next analyze the emerging evidence supporting a role of CAR in 
      NVU cells including the blood-brain barrier (BBB), a key vascular interface 
      regulating communications between the brain and the periphery. We address the 
      emerging concept of how CAR may regulate specific P450 cytochromes at the NVU and 
      the associated relevance to brain diseases. A clear understanding of how CAR 
      engages during pathological conditions could enable new mechanistic, and perhaps 
      pharmacological, entry-points within a peripheral-brain axis.
FAU - Oliviero, Fabiana
AU  - Oliviero F
AD  - Toxalim (Research Centre in Food Toxicology), Universite de Toulouse, INRAE, 
      ENVT, INP-Purpan, UPS, 31027 Toulouse, France.
FAU - Lukowicz, Celine
AU  - Lukowicz C
AD  - Toxalim (Research Centre in Food Toxicology), Universite de Toulouse, INRAE, 
      ENVT, INP-Purpan, UPS, 31027 Toulouse, France.
FAU - Boussadia, Badreddine
AU  - Boussadia B
AD  - Cerebrovascular and Glia Research, Institute of Functional Genomics (UMR 5203 
      CNRS-U 1191 INSERM, University of Montpellier), 34094 Montpellier, France.
FAU - Forner-Piquer, Isabel
AU  - Forner-Piquer I
AD  - Cerebrovascular and Glia Research, Institute of Functional Genomics (UMR 5203 
      CNRS-U 1191 INSERM, University of Montpellier), 34094 Montpellier, France.
FAU - Pascussi, Jean-Marc
AU  - Pascussi JM
AD  - Cerebrovascular and Glia Research, Institute of Functional Genomics (UMR 5203 
      CNRS-U 1191 INSERM, University of Montpellier), 34094 Montpellier, France.
FAU - Marchi, Nicola
AU  - Marchi N
AD  - Cerebrovascular and Glia Research, Institute of Functional Genomics (UMR 5203 
      CNRS-U 1191 INSERM, University of Montpellier), 34094 Montpellier, France.
FAU - Mselli-Lakhal, Laila
AU  - Mselli-Lakhal L
AD  - Toxalim (Research Centre in Food Toxicology), Universite de Toulouse, INRAE, 
      ENVT, INP-Purpan, UPS, 31027 Toulouse, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201106
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (Constitutive Androstane Receptor)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
SB  - IM
MH  - Animals
MH  - Caloric Restriction
MH  - Constitutive Androstane Receptor
MH  - *Environment
MH  - Humans
MH  - Inactivation, Metabolic
MH  - Nervous System/*blood supply
MH  - Receptors, Cytoplasmic and Nuclear/*metabolism
MH  - *Stress, Physiological
PMC - PMC7694609
OTO - NOTNLM
OT  - blood-brain barrier, stress sensor
OT  - brain
OT  - constitutive androstane receptor
OT  - environmental contaminants
OT  - liver
OT  - neurovascular unit
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/12 06:00
MHDA- 2021/06/17 06:00
PMCR- 2020/11/01
CRDT- 2020/11/11 01:02
PHST- 2020/10/06 00:00 [received]
PHST- 2020/10/27 00:00 [revised]
PHST- 2020/11/02 00:00 [accepted]
PHST- 2020/11/11 01:02 [entrez]
PHST- 2020/11/12 06:00 [pubmed]
PHST- 2021/06/17 06:00 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - cells9112426 [pii]
AID - cells-09-02426 [pii]
AID - 10.3390/cells9112426 [doi]
PST - epublish
SO  - Cells. 2020 Nov 6;9(11):2426. doi: 10.3390/cells9112426.