PMID- 33172107
OWN - NLM
STAT- MEDLINE
DCOM- 20210902
LR  - 20210902
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 10
IP  - 11
DP  - 2020 Nov 6
TI  - The Presence of Human Herpesvirus 6 in the Brain in Health and Disease.
LID - 10.3390/biom10111520 [doi]
LID - 1520
AB  - The human herpesvirus 6 (HHV-6) -A and -B are two dsDNA beta-herpesviruses 
      infectingalmost the entire worldwide population. These viruses have been 
      implicated in multipleneurological conditions in individuals of various ages and 
      immunological status, includingencephalitis, epilepsy, and febrile seizures. 
      HHV-6s have also been suggested as playing a role inthe etiology of 
      neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease. 
      Theapparent robustness of these suggested associations is contingent on the 
      accuracy of HHV-6detection in the nervous system. The effort of more than three 
      decades of researching HHV-6 in thebrain has yielded numerous observations, 
      albeit using variable technical approaches in terms oftissue preservation, 
      detection techniques, sample sizes, brain regions, and comorbidities. In 
      thisreview, we aimed to summarize current knowledge about the entry routes and 
      direct presence ofHHV-6 in the brain parenchyma at the level of DNA, RNA, 
      proteins, and specific cell types, inhealthy subjects and in those with 
      neurological conditions. We also discuss recent findings relatedto the presence 
      of HHV-6 in the brains of patients with Alzheimer's disease in light of 
      availableevidence.
FAU - Santpere, Gabriel
AU  - Santpere G
AUID- ORCID: 0000-0001-5909-8637
AD  - Neurogenomics Group, Research Programme on Biomedical Informatics (GRIB), 
      Hospital del Mar Medical Research Institute (IMIM), DCEXS, Universitat Pompeu 
      Fabra, 08003 Barcelona, Catalonia, Spain.
FAU - Telford, Marco
AU  - Telford M
AD  - Institute of Evolutionary Biology (UPF-CSIC), Departament de Ciencies 
      Experimentals i la Salut, Universitat Pompeu Fabra, PRBB, 08003 Barcelona, 
      Catalonia, Spain.
FAU - Andres-Benito, Pol
AU  - Andres-Benito P
AUID- ORCID: 0000-0003-3000-0338
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas 
      (CIBERNED), 28031 Madrid, Spain.
FAU - Navarro, Arcadi
AU  - Navarro A
AD  - Institute of Evolutionary Biology (UPF-CSIC), Departament de Ciencies 
      Experimentals i la Salut, Universitat Pompeu Fabra, PRBB, 08003 Barcelona, 
      Catalonia, Spain.
AD  - Catalan Institution of Research and Advanced Studies (ICREA), Passeig de Lluis 
      Companys 23, 08010 Barcelona, Spain.
AD  - Centre for Genomic Regulation (CRG), Barcelona Institute of Science and 
      Technology (BIST), Carrer del Dr. Aiguader 88, 08003 Barcelona, Spain.
AD  - Barcelonabetaeta Brain Research Center (BBRC), Pasqual Maragall Foundation, 
      Wellington 30, 08005 Barcelona, Spain.
FAU - Ferrer, Isidre
AU  - Ferrer I
AUID- ORCID: 0000-0001-9888-8754
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas 
      (CIBERNED), 28031 Madrid, Spain.
AD  - Department of Pathology and Experimental Therapeutics, University of Barcelona, 
      Hospitalet de Llobregat, 08907 Barcelona, Spain.
AD  - Bellvitge University Hospital, IDIBELL (Bellvitge Biomedical Research Centre), 
      Hospitalet de Llobregat, 08908 Barcelona, Spain.
LA  - eng
GR  - LCF/BQ/PI19/11690010/"la Caixa" Foundation/
GR  - PID2019-104700GA-I00/Agencia Estatal de Investigacion/
GR  - PT17/0009/0020/Spanish National Institute of Bioinformatics/
GR  - AEI-PGC2018-101927-BI00/European Regional Development Fund/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201106
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
SB  - IM
MH  - Brain/*virology
MH  - *Disease
MH  - Herpesvirus 6, Human/*physiology
MH  - Humans
PMC - PMC7694807
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - brain
OT  - encephalitis
OT  - epilepsy
OT  - human herpesvirus 6
OT  - immunohistochemistry
OT  - multiple sclerosis
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2020/11/12 06:00
MHDA- 2021/09/03 06:00
PMCR- 2020/11/01
CRDT- 2020/11/11 01:02
PHST- 2020/10/16 00:00 [received]
PHST- 2020/11/03 00:00 [revised]
PHST- 2020/11/05 00:00 [accepted]
PHST- 2020/11/11 01:02 [entrez]
PHST- 2020/11/12 06:00 [pubmed]
PHST- 2021/09/03 06:00 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - biom10111520 [pii]
AID - biomolecules-10-01520 [pii]
AID - 10.3390/biom10111520 [doi]
PST - epublish
SO  - Biomolecules. 2020 Nov 6;10(11):1520. doi: 10.3390/biom10111520.