PMID- 33172471
OWN - NLM
STAT- MEDLINE
DCOM- 20210805
LR  - 20210805
IS  - 1756-6606 (Electronic)
IS  - 1756-6606 (Linking)
VI  - 13
IP  - 1
DP  - 2020 Nov 10
TI  - Selective role of the translin/trax RNase complex in hippocampal synaptic 
      plasticity.
PG  - 145
LID - 10.1186/s13041-020-00691-5 [doi]
LID - 145
AB  - Activity-dependent local protein synthesis is critical for synapse-specific, 
      persistent plasticity. Abnormalities in local protein synthesis have been 
      implicated in psychiatric disorders. We have recently identified the 
      translin/trax microRNA-degrading enzyme as a novel mediator of protein synthesis 
      at activated synapses. Additionally, translin knockout (KO) mice, which lack 
      translin/trax, exhibit some of the behavioral abnormalities found in a mouse 
      model of fragile X syndrome (fragile X mental retardation protein-FMRP-KO mice). 
      Therefore, identifying signaling pathways interacting with translin/trax to 
      support persistent synaptic plasticity is a translationally relevant goal. Here, 
      as a first step to achieve this goal, we have assessed the requirement of 
      translin/trax for multiple hippocampal synaptic plasticity paradigms that rely on 
      distinct molecular mechanisms. We found that mice lacking translin/trax exhibited 
      selective impairment in a form of persistent hippocampal plasticity, which 
      requires postsynaptic protein kinase A (PKA) activity. In contrast, enduring 
      forms of plasticity that are dependent on presynaptic PKA were unaffected. 
      Furthermore, these mice did not display exaggerated metabotropic glutamate 
      receptor-mediated long-term synaptic depression (mGluR-LTD), a hallmark of the 
      FMRP KO mice. On the contrary, translin KO mice exhibited deficits in 
      N-methyl-D-aspartate receptor (NMDAR) dependent LTD, a phenotype not observed in 
      the FMRP knockouts. Taken together, these findings demonstrate that translin/trax 
      mediates long-term synaptic plasticity that is dependent on postsynaptic PKA 
      signaling and suggest that translin/trax and FMRP play distinct roles in 
      hippocampal synaptic plasticity.
FAU - Park, Alan Jung
AU  - Park AJ
AD  - Department of Biology, University of Pennsylvania, Philadelphia, PA, USA. 
      alanjpark2014@gmail.com.
AD  - Gogos Lab, Mortimer B. Zuckerman Mind Brain Behavior Institute, Jerome L. Greene 
      Science Center, Columbia University, L5-053, 3227 Broadway, New York, NY, 10027, 
      USA. alanjpark2014@gmail.com.
FAU - Shetty, Mahesh Shivarama
AU  - Shetty MS
AD  - Department of Neuroscience and Pharmacology, Carver College of Medicine, 
      University of Iowa, 2-471 Bowen Science Building, 51 Newton Road, Iowa City, IA, 
      52242, USA.
AD  - Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, 2312 
      Pappajohn Biomedical Discovery Building, 169 Newton Road, Iowa City, 52242, IA, 
      USA.
FAU - Baraban, Jay M
AU  - Baraban JM
AD  - The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School 
      of Medicine, Baltimore, MD, USA.
FAU - Abel, Ted
AU  - Abel T
AUID- ORCID: 0000-0003-2423-4592
AD  - Department of Biology, University of Pennsylvania, Philadelphia, PA, USA. 
      ted-abel@uiowa.edu.
AD  - Department of Neuroscience and Pharmacology, Carver College of Medicine, 
      University of Iowa, 2-471 Bowen Science Building, 51 Newton Road, Iowa City, IA, 
      52242, USA. ted-abel@uiowa.edu.
AD  - Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, 2312 
      Pappajohn Biomedical Discovery Building, 169 Newton Road, Iowa City, 52242, IA, 
      USA. ted-abel@uiowa.edu.
LA  - eng
GR  - R01 MH087463/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20201110
PL  - England
TA  - Mol Brain
JT  - Molecular brain
JID - 101468876
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Tsn protein, mouse)
RN  - 0 (Tsnax protein, mouse)
RN  - 139135-51-6 (Fragile X Mental Retardation Protein)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
SB  - IM
EIN - Mol Brain. 2021 Mar 5;14(1):48. PMID: 33673835
MH  - Animals
MH  - Cyclic AMP-Dependent Protein Kinases/metabolism
MH  - DNA-Binding Proteins/*metabolism
MH  - Fragile X Mental Retardation Protein/metabolism
MH  - Hippocampus/*physiology
MH  - Long-Term Potentiation/physiology
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Models, Biological
MH  - *Neuronal Plasticity
MH  - RNA-Binding Proteins/*metabolism
MH  - Receptors, Metabotropic Glutamate/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
PMC - PMC7653721
OTO - NOTNLM
OT  - FMRP
OT  - Hippocampal synaptic plasticity
OT  - Local protein synthesis
OT  - Long-term depression
OT  - Long-term potentiation
OT  - PKA
OT  - RNA-binding protein
OT  - Translin
OT  - Trax
OT  - microRNA
COIS- The authors declare that they have no competing interests.
EDAT- 2020/11/12 06:00
MHDA- 2021/08/06 06:00
PMCR- 2020/11/10
CRDT- 2020/11/11 05:36
PHST- 2020/05/16 00:00 [received]
PHST- 2020/10/30 00:00 [accepted]
PHST- 2020/11/11 05:36 [entrez]
PHST- 2020/11/12 06:00 [pubmed]
PHST- 2021/08/06 06:00 [medline]
PHST- 2020/11/10 00:00 [pmc-release]
AID - 10.1186/s13041-020-00691-5 [pii]
AID - 691 [pii]
AID - 10.1186/s13041-020-00691-5 [doi]
PST - epublish
SO  - Mol Brain. 2020 Nov 10;13(1):145. doi: 10.1186/s13041-020-00691-5.