PMID- 33173455
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 1660-3796 (Print)
IS  - 1660-3818 (Electronic)
IS  - 1660-3796 (Linking)
VI  - 47
IP  - 5
DP  - 2020 Oct
TI  - Characteristics of Recipients of Red Blood Cell Concentrates in a German Federal 
      State.
PG  - 370-377
LID - 10.1159/000510207 [doi]
AB  - BACKGROUND: Annual transfusion rates in many European countries range between 25 
      and 35 red blood cell concentrates (RBCs)/1,000 population. It is unclear why 
      transfusion rates in Germany are considerably higher (approx. 50-55 RBCs/1,000 
      population). METHODS: We assessed the characteristics of transfusion recipients 
      at all hospitals of the German federal state Mecklenburg-Western Pomerania during 
      a 10-year longitudinal study. RESULTS: Although 75% of patients received </=4 
      RBCs/patient in 2015 (1 RBC: 11.3%; 2 RBCs: 42.6%; 3 RBCs: 6.3%; 4 RBCs: 15.0%), 
      the mean transfusion index was 4.6 RBCs due to a minority of patients with a high 
      transfusion demand. Two thirds of all RBCs were transfused to only 25% of RBC 
      recipients. Consistently, male patients received a higher number of RBCs (2005: 
      54.2%; 2015: 56.8%) and had a higher mean transfusion index than female patients 
      (mean 5.1 +/- 7.2; median 2; inter-quartile range [IQR] 2-4 vs. mean 4.0 +/- 5.8; 
      median 2; IQR 2-4). The absolute transfusion demand decreased between 2005 and 
      2015 by 13.5% due to a composite of active reduction (clinical practice change) 
      and population decline in the 65- to 75-year age group (lower birth rate cohort 
      1940-1950); however, with major differences between hospitals (range from -61.0 
      to +41.4%). CONCLUSION: Transfusion demand in a population could largely be 
      driven by patients with high transfusion demand. Different treatment practices in 
      this group of patients probably add to the major differences in transfusion 
      demand per 1,000 individuals between countries. The available data cannot prove 
      this hypothesis. Implementation of a diagnosis-related group-based monitoring 
      system is urgently needed to allow informative monitoring on the population level 
      and meaningful comparisons between transfusion practices.
CI  - Copyright (c) 2020 by S. Karger AG, Basel.
FAU - Schonborn, Linda
AU  - Schonborn L
AD  - Institut fur Immunologie und Transfusionsmedizin, Universitatsmedizin Greifswald, 
      Greifswald, Germany.
FAU - Weitmann, Kerstin
AU  - Weitmann K
AD  - Institut fur Community Medicine, Universitatsmedizin Greifswald, Greifswald, 
      Germany.
FAU - Greinacher, Andreas
AU  - Greinacher A
AD  - Institut fur Immunologie und Transfusionsmedizin, Universitatsmedizin Greifswald, 
      Greifswald, Germany.
FAU - Hoffmann, Wolfgang
AU  - Hoffmann W
AD  - Institut fur Community Medicine, Universitatsmedizin Greifswald, Greifswald, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20200922
PL  - Switzerland
TA  - Transfus Med Hemother
JT  - Transfusion medicine and hemotherapy : offizielles Organ der Deutschen 
      Gesellschaft fur Transfusionsmedizin und Immunhamatologie
JID - 101176417
PMC - PMC7590768
OTO - NOTNLM
OT  - Blood supply
OT  - Demographic change
OT  - Red blood cell concentrates
COIS- All authors declare that they have no conflicts of interest.
EDAT- 2020/11/12 06:00
MHDA- 2020/11/12 06:01
PMCR- 2020/09/22
CRDT- 2020/11/11 05:58
PHST- 2020/04/18 00:00 [received]
PHST- 2020/07/05 00:00 [accepted]
PHST- 2020/11/11 05:58 [entrez]
PHST- 2020/11/12 06:00 [pubmed]
PHST- 2020/11/12 06:01 [medline]
PHST- 2020/09/22 00:00 [pmc-release]
AID - tmh-0047-0370 [pii]
AID - 10.1159/000510207 [doi]
PST - ppublish
SO  - Transfus Med Hemother. 2020 Oct;47(5):370-377. doi: 10.1159/000510207. Epub 2020 
      Sep 22.