PMID- 33173515
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201113
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 11
DP  - 2020
TI  - Neural and Self-Report Markers of Reassurance: A Generalized Additive Modelling 
      Approach.
PG  - 566141
LID - 10.3389/fpsyt.2020.566141 [doi]
LID - 566141
AB  - Research has shown that engaging in self-reassurance, a compassionately motivated 
      cognitive relating style, can down-regulate neural markers of threat and pain. 
      Whilst important, the relationship between neural and self-report markers of 
      reassurance are largely unknown. Here we analyzed previously published fMRI data 
      which measured neural responses when participants engaged in self-reassurance 
      toward a mistake, setback, or failure. Within the present paper, we identified 
      correlations between regions of interest extracted during self-reassurance with 
      fMRI and self-report data. Using generalized additive modelling, we show that 
      participants with greater inadequate forms of self-criticism exhibited greater 
      neural activation within the medial prefrontal cortex (MPFC) and anterior insula 
      (AI). Furthermore, a relationship between greater fears of expressing compassion 
      to the self and neural activation within the MPFC returned non-significant after 
      correction for multiple comparisons. No significant relationships were observed 
      between brain activation and hated and reassuring forms of self-criticism. Our 
      results identify preliminary evidence for neural activity during self-reassurance 
      as correlated with self-report markers, and we outline a method for modelling 
      neural and self-report data which can be applied to future studies in compassion 
      science, particularly with a clinical sample.
CI  - Copyright (c) 2020 Kim, Henderson, Best, Cunnington and Kirby.
FAU - Kim, Jeffrey J
AU  - Kim JJ
AD  - Compassionate Mind Research Group, School of Psychology, The University of 
      Queensland, Brisbane, QLD, Australia.
AD  - The Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, 
      Australia.
FAU - Henderson, Trent
AU  - Henderson T
AD  - Orbisant Analytics, Brisbane, QLD, Australia.
FAU - Best, Talitha
AU  - Best T
AD  - School of Health, Medical and Applied Sciences, Central Queensland University, 
      Brisbane, QLD, Australia.
FAU - Cunnington, Ross
AU  - Cunnington R
AD  - Compassionate Mind Research Group, School of Psychology, The University of 
      Queensland, Brisbane, QLD, Australia.
FAU - Kirby, James N
AU  - Kirby JN
AD  - Compassionate Mind Research Group, School of Psychology, The University of 
      Queensland, Brisbane, QLD, Australia.
LA  - eng
PT  - Journal Article
DEP - 20200923
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC7538506
OTO - NOTNLM
OT  - compassion
OT  - criticism
OT  - fMRI
OT  - modelling
OT  - reassurance
OT  - self-report
EDAT- 2020/11/12 06:00
MHDA- 2020/11/12 06:01
PMCR- 2020/09/23
CRDT- 2020/11/11 05:58
PHST- 2020/07/03 00:00 [received]
PHST- 2020/09/01 00:00 [accepted]
PHST- 2020/11/11 05:58 [entrez]
PHST- 2020/11/12 06:00 [pubmed]
PHST- 2020/11/12 06:01 [medline]
PHST- 2020/09/23 00:00 [pmc-release]
AID - 10.3389/fpsyt.2020.566141 [doi]
PST - epublish
SO  - Front Psychiatry. 2020 Sep 23;11:566141. doi: 10.3389/fpsyt.2020.566141. 
      eCollection 2020.