PMID- 33173987
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20221207
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 22
IP  - 6
DP  - 2020 Dec
TI  - Effects of nicorandil on p120 expression in the spinal cord and dorsal root 
      ganglion of rats with chronic postsurgical pain.
PG  - 4821-4827
LID - 10.3892/mmr.2020.11546 [doi]
AB  - Chronic postsurgical pain (CPSP) has a high incidence, but the underlying 
      mechanism is not well understood. Accumulating evidence has suggested that 
      central sensitization is the main mechanism of pain. To study the role of p120 in 
      CPSP, a skin/muscle incision and retraction (SMIR) model was established, and 
      immunofluorescence staining and western blotting were performed to analyze the 
      expression of p120 in the spinal cord and dorsal root ganglion (DRG). The results 
      demonstrated that SMIR increased the expression of p120 in the DRG and the spinal 
      cord compared with the naive group. Furthermore, it was demonstrated that p120 
      was mainly distributed in the glial fibrillary acidic protein‑positive astrocytes 
      in the spinal cord, and in the neurofilament 200‑positive medium and large 
      neurons in the DRG. Our previous studies have shown that adenosine 
      triphosphate‑sensitive potassium channel (KATP) agonists can reduce postoperative 
      pain in rats. Therefore, the changes in p120 were observed in the DRG and spinal 
      cord of rats following the intraperitoneal injection of nicorandil, a KATP 
      agonist. It was demonstrated that nicorandil administration could relieve 
      mechanical pain experienced following SMIR in rats, and decrease the expression 
      of p120 in the DRG and spinal cord. The results revealed that p120 may contribute 
      to the prophylactic analgesic effect of nicorandil, thus providing a novel 
      insight into the mechanism of CPSP prevention.
FAU - Huang, Sai-Sai
AU  - Huang SS
AD  - Department of Anesthesiology, The First Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu 215000, P.R. China.
FAU - Cao, Su
AU  - Cao S
AD  - Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, 
      Jiangsu 226001, P.R. China.
FAU - Lu, Cui E
AU  - Lu CE
AD  - Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, 
      Jiangsu 226001, P.R. China.
FAU - Qin, Yi-Bin
AU  - Qin YB
AD  - Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, 
      Jiangsu 226001, P.R. China.
FAU - Yang, Jian-Ping
AU  - Yang JP
AD  - Department of Anesthesiology, The First Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu 215000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20200928
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Catenins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 260456HAM0 (Nicorandil)
RN  - 0 (Delta Catenin)
SB  - IM
MH  - Animals
MH  - Astrocytes/metabolism
MH  - Catenins/*metabolism
MH  - Chronic Pain/*drug therapy/metabolism
MH  - Ganglia, Spinal/drug effects/metabolism
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hyperalgesia/drug therapy/metabolism
MH  - Male
MH  - Nicorandil/*pharmacology/therapeutic use
MH  - Pain Measurement
MH  - Pain, Postoperative/*drug therapy/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/*drug effects/metabolism
MH  - Delta Catenin
PMC - PMC7646919
EDAT- 2020/11/12 06:00
MHDA- 2021/05/26 06:00
PMCR- 2020/09/28
CRDT- 2020/11/11 06:00
PHST- 2020/02/20 00:00 [received]
PHST- 2020/08/21 00:00 [accepted]
PHST- 2020/11/12 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2020/11/11 06:00 [entrez]
PHST- 2020/09/28 00:00 [pmc-release]
AID - mmr-22-06-4821 [pii]
AID - 10.3892/mmr.2020.11546 [doi]
PST - ppublish
SO  - Mol Med Rep. 2020 Dec;22(6):4821-4827. doi: 10.3892/mmr.2020.11546. Epub 2020 Sep 
      28.