PMID- 33178053
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 11
DP  - 2020
TI  - Assessment of Serum Cytokines and Oxidative Stress Markers in Elite Athletes 
      Reveals Unique Profiles Associated With Different Sport Disciplines.
PG  - 600888
LID - 10.3389/fphys.2020.600888 [doi]
LID - 600888
AB  - OBJECTIVES: Circulating cytokines and oxidative stress markers vary in response 
      to different exercise regimens. This study aims to compare the 
      immune-inflammatory and oxidative stress profiles of elite athletes from 
      different sport disciplines as potential biomarkers of muscle damage, and 
      cardiovascular demand. METHODS: Serum samples from 88 consented elite male 
      athletes from different sports disciplines (aquatics, n = 11, athletics, n = 22, 
      cycling, n = 19, football, n = 28 and weightlifting, n = 8) collected at the 
      anti-doping lab in Italy were screened for 38 cytokines and oxidative stress 
      markers. Comparisons were made between different level of power, cardiovascular 
      demand (CD) and endurance, as well as among the sport types. RESULTS: The 
      anti-inflammatory interleukin (IL)-10 was higher (p = 0.04) in moderate power 
      compared with the high power group. Conversely, superoxide dismutase (SOD; p = 
      0.001) and malondialdehyde (MDA; p = 0.007) levels were greater in the higher 
      power groups compared with the lower power counterpart. Among athletes who belong 
      to different CD ranks, IL-1beta and monocyte chemoattractant protein-1(MCP1) levels 
      were higher (p = 0.03) in the low CD-rank group compared with high CD 
      counterpart, whereas, SOD levels were higher (p = 0.001) in high and moderate 
      CD-rank groups compared to low counterpart. For endurance groups, IL-10 and 
      macrophage inflammatory protein (MIP)-1beta were increased (p = 0.03) in 
      low/moderate endurance compared with the high endurance group. Finally, 
      MIP1-beta, SOD and catalase varied significantly among the sports groups. 
      CONCLUSION: Specific markers of inflammation and oxidative stress are associated 
      with different sports disciplines and could be utilized as potential biomarkers 
      of athletes' health, performance, and recovery from injury.
CI  - Copyright (c) 2020 Sohail, Al-Mansoori, Al-Jaber, Georgakopoulos, Donati, Botre, 
      Sellami and Elrayess.
FAU - Sohail, Muhammad U
AU  - Sohail MU
AD  - Biomedical Research Center, Qatar University, Doha, Qatar.
FAU - Al-Mansoori, Layla
AU  - Al-Mansoori L
AD  - Biomedical Research Center, Qatar University, Doha, Qatar.
FAU - Al-Jaber, Hend
AU  - Al-Jaber H
AD  - Biomedical Research Center, Qatar University, Doha, Qatar.
FAU - Georgakopoulos, Costas
AU  - Georgakopoulos C
AD  - Anti-Doping Laboratory Qatar, Doha, Qatar.
FAU - Donati, Francesco
AU  - Donati F
AD  - Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Rome, Italy.
FAU - Botre, Francesco
AU  - Botre F
AD  - Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Rome, Italy.
FAU - Sellami, Maha
AU  - Sellami M
AD  - College of Art and Science, Sport Science Program, Qatar University, Doha, Qatar.
FAU - Elrayess, Mohamed A
AU  - Elrayess MA
AD  - Biomedical Research Center, Qatar University, Doha, Qatar.
LA  - eng
PT  - Journal Article
DEP - 20201015
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC7593763
OTO - NOTNLM
OT  - biomarkers
OT  - cardiovascular demand
OT  - cytokines
OT  - elite athletes
OT  - endurance
OT  - oxidative stress
OT  - power
EDAT- 2020/11/13 06:00
MHDA- 2020/11/13 06:01
PMCR- 2020/10/15
CRDT- 2020/11/12 05:42
PHST- 2020/08/31 00:00 [received]
PHST- 2020/09/23 00:00 [accepted]
PHST- 2020/11/12 05:42 [entrez]
PHST- 2020/11/13 06:00 [pubmed]
PHST- 2020/11/13 06:01 [medline]
PHST- 2020/10/15 00:00 [pmc-release]
AID - 10.3389/fphys.2020.600888 [doi]
PST - epublish
SO  - Front Physiol. 2020 Oct 15;11:600888. doi: 10.3389/fphys.2020.600888. eCollection 
      2020.