PMID- 33178217
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20210622
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - The Role Played by Mitochondria in FcepsilonRI-Dependent Mast Cell Activation.
PG  - 584210
LID - 10.3389/fimmu.2020.584210 [doi]
LID - 584210
AB  - Mast cells play a key role in the regulation of innate and adaptive immunity and 
      are involved in pathogenesis of many inflammatory and allergic diseases. The most 
      studied mechanism of mast cell activation is mediated by the interaction of 
      antigens with immunoglobulin E (IgE) and a subsequent binding with the 
      high-affinity receptor Fc epsilon RI (FcepsilonRI). Increasing evidences indicated that 
      mitochondria are actively involved in the FcepsilonRI-dependent activation of this type 
      of cells. Here, we discuss changes in energy metabolism and mitochondrial 
      dynamics during IgE-antigen stimulation of mast cells. We reviewed the recent 
      data with regards to the role played by mitochondrial membrane potential, 
      mitochondrial calcium ions (Ca(2+)) influx and reactive oxygen species (ROS) in 
      mast cell FcepsilonRI-dependent activation. Additionally, in the present review we have 
      discussed the crucial role played by the pyruvate dehydrogenase (PDH) complex, 
      transcription factors signal transducer and activator of transcription 3 (STAT3) 
      and microphthalmia-associated transcription factor (MITF) in the development and 
      function of mast cells. These two transcription factors besides their nuclear 
      localization were also found to translocate in to the mitochondria and functions 
      as direct modulators of mitochondrial activity. Studying the role played by mast 
      cell mitochondria following their activation is essential for expanding our basic 
      knowledge about mast cell physiological functions and would help to design 
      mitochondria-targeted anti-allergic and anti-inflammatory drugs.
CI  - Copyright (c) 2020 Chelombitko, Chernyak, Fedorov, Zinovkin, Razin and Paruchuru.
FAU - Chelombitko, Maria A
AU  - Chelombitko MA
AD  - Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State 
      University, Moscow, Russia.
FAU - Chernyak, Boris V
AU  - Chernyak BV
AD  - Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State 
      University, Moscow, Russia.
FAU - Fedorov, Artem V
AU  - Fedorov AV
AD  - Department of Cell Biology and Histology, Biology Faculty, Lomonosov Moscow State 
      University, Moscow, Russia.
FAU - Zinovkin, Roman A
AU  - Zinovkin RA
AD  - Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State 
      University, Moscow, Russia.
AD  - Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical 
      University, Moscow, Russia.
FAU - Razin, Ehud
AU  - Razin E
AD  - Department of Biochemistry and Molecular Biology, School of Medicine, Hebrew 
      University of Jerusalem, Jerusalem, Israel.
FAU - Paruchuru, Lakhsmi Bhargavi
AU  - Paruchuru LB
AD  - Department of Biochemistry and Molecular Biology, School of Medicine, Hebrew 
      University of Jerusalem, Jerusalem, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201016
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Microphthalmia-Associated Transcription Factor)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - SY7Q814VUP (Calcium)
SB  - IM
EIN - Front Immunol. 2020 Dec 11;11:620293. PMID: 33362803
MH  - Animals
MH  - Calcium/metabolism
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Mast Cells/*metabolism/*physiology
MH  - Microphthalmia-Associated Transcription Factor/metabolism
MH  - Mitochondria/*metabolism/*physiology
MH  - Receptors, IgE/*metabolism
MH  - Signal Transduction/physiology
PMC - PMC7596649
OTO - NOTNLM
OT  - FcepsilonRI-dependent activation
OT  - IgE
OT  - allergy
OT  - mast cell
OT  - mitochondria
EDAT- 2020/11/13 06:00
MHDA- 2021/06/23 06:00
PMCR- 2020/01/01
CRDT- 2020/11/12 05:42
PHST- 2020/07/16 00:00 [received]
PHST- 2020/08/20 00:00 [accepted]
PHST- 2020/11/12 05:42 [entrez]
PHST- 2020/11/13 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.584210 [doi]
PST - epublish
SO  - Front Immunol. 2020 Oct 16;11:584210. doi: 10.3389/fimmu.2020.584210. eCollection 
      2020.