PMID- 33178269
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2020
DP  - 2020
TI  - Sarcopenia in Type 2 Diabetes Mellitus: A Cross-Sectional Observational Study.
PG  - 7841390
LID - 10.1155/2020/7841390 [doi]
LID - 7841390
AB  - BACKGROUND: The aim of this study was to compare the prevalence of low muscle 
      mass and sarcopenia in patients with type 2 diabetes mellitus (T2DM) versus 
      paired controls (control group, CG) and the association between sarcopenia and 
      chronic diabetes complications. METHODS: Men and women >/=50 years with T2DM (T2DM 
      group, T2DMG) were recruited during routine outpatient visits. Total body 
      densitometry and handgrip strength (HGS) were evaluated in the T2DMG and CG, 
      while the T2DMG was also evaluated for the physical performance using the gait 
      speed (GS) test. Sarcopenia was diagnosed according to the criteria of the 
      Foundation for the National Institutes of Health Sarcopenia Project (FNIH). 
      RESULTS: The study included 177 individuals in the T2DMG and 146 in the CG. The 
      mean HGS value was lower in the T2DMG (24.4 +/- 10.3 kg) compared with the CG 
      (30.9 +/- 9.15 kg), p < 0.001, with low HGS in 46 (25.9%) and 10 (9%) in the T2DMG 
      and CG, respectively (p < 0.001). The prevalence of sarcopenia defined according 
      to the FNIH criteria was higher in the T2DMG 23 (12.9%) compared with the CG 8 
      (5.4%), p < 0.03. The presence of albuminuria increased the odds of sarcopenia 
      (odds ratio (OR) 2.84, 95% confidence interval (CI) 1.07-7.68, p=0.04) and 
      osteoporosis (OR 3.38, 95% CI 1.12-9.89, p=0.03), even in patients with mild to 
      moderate nephropathy. The body composition analysis showed increased odds of 
      sarcopenia with increased percentage of total fat (%TF) in women (OR 1.18, 95% 
      CI, 1.03-1.43, p=0.03) and men (OR 1.31, 95% CI, 1.10-1.75, p=0.01). CONCLUSION: 
      Patients with T2DM presenting with albuminuria, osteoporosis, and increased %TF 
      were more likely to have sarcopenia. This finding emphasizes the need for 
      patients with T2DM to be evaluated for sarcopenia to allow for early 
      implementation of measures to prevent or treat this disorder.
CI  - Copyright (c) 2020 L. M. Pechmann et al.
FAU - Pechmann, L M
AU  - Pechmann LM
AUID- ORCID: 0000-0002-2965-5268
AD  - Internal Medicine and Endocrine Division (SEMPR), Universidade Federal do Parana, 
      Centro de Diabetes Curitiba, Curitiba, PR, Brazil.
FAU - Jonasson, T H
AU  - Jonasson TH
AUID- ORCID: 0000-0002-1857-4737
AD  - Endocrine Division, Hospital de Clinicas da Universidade Federal Do Parana 
      (SEMPR), Avenida Agostinho Leao Junior, 285, Alto da Gloria, Curitiba, PR 
      80030-110, Brazil.
FAU - Canossa, V S
AU  - Canossa VS
AUID- ORCID: 0000-0001-7062-7085
AD  - Universidade Federal do Parana, Curitiba, PR, Brazil.
FAU - Trierweiler, H
AU  - Trierweiler H
AUID- ORCID: 0000-0003-4879-587X
AD  - Universidade Federal do Parana, Curitiba, PR, Brazil.
FAU - Kisielewicz, G
AU  - Kisielewicz G
AD  - Universidade Federal do Parana, Curitiba, PR, Brazil.
FAU - Petterle, R R
AU  - Petterle RR
AUID- ORCID: 0000-0001-7735-1077
AD  - Department of Integrative Medicine, Federal University of Parana, Curitiba, PR, 
      Brazil.
FAU - Moreira, C A
AU  - Moreira CA
AUID- ORCID: 0000-0002-9908-4907
AD  - Endocrine Division, Hospital de Clinicas da Universidade Federal Do Parana 
      (SEMPR), Avenida Agostinho Leao Junior, 285, Alto da Gloria, Curitiba, PR 
      80030-110, Brazil.
FAU - Borba, V Z C
AU  - Borba VZC
AUID- ORCID: 0000-0003-0555-0880
AD  - Endocrine Division, Hospital de Clinicas da Universidade Federal Do Parana 
      (SEMPR), Avenida Agostinho Leao Junior, 285, Alto da Gloria, Curitiba, PR 
      80030-110, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20201029
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC7644336
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/11/13 06:00
MHDA- 2020/11/13 06:01
PMCR- 2020/10/29
CRDT- 2020/11/12 05:43
PHST- 2020/07/06 00:00 [received]
PHST- 2020/09/25 00:00 [revised]
PHST- 2020/10/04 00:00 [accepted]
PHST- 2020/11/12 05:43 [entrez]
PHST- 2020/11/13 06:00 [pubmed]
PHST- 2020/11/13 06:01 [medline]
PHST- 2020/10/29 00:00 [pmc-release]
AID - 10.1155/2020/7841390 [doi]
PST - epublish
SO  - Int J Endocrinol. 2020 Oct 29;2020:7841390. doi: 10.1155/2020/7841390. 
      eCollection 2020.