PMID- 33178406
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210423
IS  - 2000-8066 (Print)
IS  - 2000-8066 (Electronic)
IS  - 2000-8066 (Linking)
VI  - 11
IP  - 1
DP  - 2020 Oct 23
TI  - The sense of self in the aftermath of trauma: lessons from the default mode 
      network in posttraumatic stress disorder.
PG  - 1807703
LID - 10.1080/20008198.2020.1807703 [doi]
LID - 1807703
AB  - Trauma can profoundly affect the sense of self, where both cognitive and somatic 
      disturbances to the sense of self are reported clinically by individuals with 
      posttraumatic stress disorder (PTSD). These disturbances are captured eloquently 
      by clinical accounts, such as, 'I do not know myself anymore,' 'I will never be 
      able to experience normal emotions again,' and, 'I feel dead inside.' 
      Self-related thoughts and experiences are represented neurobiologically by a 
      large-scale, cortical network located along the brain's mid-line and referred to 
      as the default mode network (DMN). Recruited predominantly during rest in healthy 
      participants, the DMN is also active during self-referential and autobiographical 
      memory processing - processes which, collectively, are thought to provide the 
      foundation for a stable sense of self that persists across time and may be 
      available for conscious access. In participants with PTSD, however, the DMN shows 
      substantially reduced resting-state functional connectivity as compared to 
      healthy individuals, with greater reductions associated with heightened PTSD 
      symptom severity. Critically, individuals with PTSD describe frequently that 
      their traumatic experiences have become intimately linked to their perceived 
      sense of self, a perception which may be mediated, in part, by alterations in the 
      DMN. Accordingly, identification of alterations in the functional connectivity of 
      the DMN during rest, and during subliminal, trauma-related stimulus conditions, 
      has the potential to offer critical insight into the dynamic interplay between 
      trauma- and self-related processing in PTSD. Here, we discuss DMN-related 
      alterations during these conditions, pointing further towards the clinical 
      significance of these findings in relation to past- and present-centred therapies 
      for the treatment of PTSD.
CI  - (c) 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & 
      Francis Group.
FAU - Lanius, Ruth A
AU  - Lanius RA
AUID- ORCID: 0000-0002-3758-1393
AD  - Department of Neuroscience, Western University, London, Ontario, Canada.
AD  - Department of Psychiatry, Western University, London, Ontario, Canada.
AD  - Imaging Division, Lawson Health Research Institute, London, Ontario, Canada.
FAU - Terpou, Braeden A
AU  - Terpou BA
AUID- ORCID: 0000-0002-6770-2715
AD  - Department of Neuroscience, Western University, London, Ontario, Canada.
FAU - McKinnon, Margaret C
AU  - McKinnon MC
AD  - Mood Disorders Program, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
AD  - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 
      Hamilton, Ontario, Canada.
AD  - Homewood Research Institute, Guelph, Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20201023
PL  - United States
TA  - Eur J Psychotraumatol
JT  - European journal of psychotraumatology
JID - 101559025
PMC - PMC7594748
OTO - NOTNLM
OT  - MDMA
OT  - PTSD
OT  - default mode network
OT  - medial prefrontal cortex
OT  - past-centred
OT  - posterior cingulate cortex
OT  - present-centred treatment
OT  - sense of self
OT  - somatic
OT  - trauma
OT  - treatment
OT  - * Trauma may impact significantly an individual's sense of self.* The default 
      mode network is thought to confer a stable sense of self.* We discuss alterations 
      in connectivity in this network in PTSD and their clinical significance.
COIS- No potential conflict of interest was reported by the authors.
EDAT- 2020/11/13 06:00
MHDA- 2020/11/13 06:01
PMCR- 2020/10/23
CRDT- 2020/11/12 05:43
PHST- 2020/11/12 05:43 [entrez]
PHST- 2020/11/13 06:00 [pubmed]
PHST- 2020/11/13 06:01 [medline]
PHST- 2020/10/23 00:00 [pmc-release]
AID - 1807703 [pii]
AID - 10.1080/20008198.2020.1807703 [doi]
PST - epublish
SO  - Eur J Psychotraumatol. 2020 Oct 23;11(1):1807703. doi: 
      10.1080/20008198.2020.1807703.