PMID- 33178870
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2322-3480 (Print)
IS  - 2322-3480 (Electronic)
IS  - 2322-3480 (Linking)
VI  - 9
IP  - 2
DP  - 2020 Jul
TI  - Analysis of Single Nucleotide Polymorphisms in HLA-DRA, IL2RA , and HMGB1 Genes 
      in Multiple Sclerosis.
PG  - 198-208
LID - 10.29252/rbmb.9.2.199 [doi]
AB  - BACKGROUND: Multiple sclerosis (MS) is a common demyelinating neurodegenerative 
      disorder with significant heritability. Previous studies have associated genetic 
      variants in human leukocyte antigen (HLA) complex, IL2RA , and HMGB1 genes with 
      the pathophysiology of MS. METHODS: In order to investigate the gene association 
      in the Iranian population, we performed a genotyping study of 36 variants in the 
      mentioned genes using Sanger sequencing in 102 MS patients and 113 healthy 
      controls. RESULTS: Our results identified significant associations as well as 
      significant allele frequency differences in some of the studied single-nucleotide 
      polymorphisms including rs4935356, rs3177928, and rs7197 from HLA-DRA gene, and 
      rs12722489 and rs12722490 variants from IL2RA gene (p< 0.05). Moreover, the 
      strong linkage disequilibrium of two common haplotypes was estimated from the 
      HLA-DRA gene. CONCLUSION: This association study may suggest the role of these 
      polymorphisms in the genetic susceptibility of MS in the Iranian population and 
      would facilitate the recognition of causative variants in this disease.
FAU - Asouri, Mohsen
AU  - Asouri M
AD  - Department of Molecular Medicine, Biotechnology Research Center, Pasteur 
      Institute of Iran, Tehran, Iran.
AD  - North Research Center, Pasteur Institute of Iran, Amol, Iran.
FAU - Alinejad Rokni, Hamid
AU  - Alinejad Rokni H
AD  - Systems Biology and Health Data Analytics Lab, the Graduate School of Biomedical 
      Engineering, UNSW Sydney, 2052, NSW, AU.
FAU - Sahraian, Mohammad Ali
AU  - Sahraian MA
AD  - Multiple Sclerosis Research Center; Neuroscience Institute, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Fattahi, Sadegh
AU  - Fattahi S
AD  - North Research Center, Pasteur Institute of Iran, Amol, Iran.
FAU - Motamed, Nima
AU  - Motamed N
AD  - Department of Social Medicine, Zanjan University of Medical Sciences, Zanjan, 
      Iran.
FAU - Doosti, Rozita
AU  - Doosti R
AD  - Multiple Sclerosis Research Center; Neuroscience Institute, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Rahimi, Hamzeh
AU  - Rahimi H
AD  - Department of Molecular Medicine, Biotechnology Research Center, Pasteur 
      Institute of Iran, Tehran, Iran.
FAU - Lotfi, Maryam
AU  - Lotfi M
AD  - North Research Center, Pasteur Institute of Iran, Amol, Iran.
FAU - Moslemi, Azam
AU  - Moslemi A
AD  - Department of Biostatistics, Faculty of Medical Sciences, Arak University of 
      Medical Sciences, Arak, Iran.
FAU - Karimpoor, Morteza
AU  - Karimpoor M
AD  - Department of Molecular Medicine, Biotechnology Research Center, Pasteur 
      Institute of Iran, Tehran, Iran.
FAU - Mahboudi, Fereidoun
AU  - Mahboudi F
AD  - Department of Molecular Medicine, Biotechnology Research Center, Pasteur 
      Institute of Iran, Tehran, Iran.
FAU - Akhavan-Niaki, Haleh
AU  - Akhavan-Niaki H
AD  - Zoonoses Research Center, North Research Center, Pasteur Institute of Iran, Amol, 
      Iran.
AD  - Department of Genetics, Faculty of Medicine, Babol University of Medical 
      Sciences, Babol, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Rep Biochem Mol Biol
JT  - Reports of biochemistry & molecular biology
JID - 101637937
PMC - PMC7603253
OTO - NOTNLM
OT  - HMGB1
OT  - L2RA
OT  - HLA-DRA
OT  - Multiple sclerosis
OT  - Polymorphism
EDAT- 2020/11/13 06:00
MHDA- 2020/11/13 06:01
PMCR- 2020/07/01
CRDT- 2020/11/12 05:45
PHST- 2020/11/12 05:45 [entrez]
PHST- 2020/11/13 06:00 [pubmed]
PHST- 2020/11/13 06:01 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - rbmb-9-199 [pii]
AID - 10.29252/rbmb.9.2.199 [doi]
PST - ppublish
SO  - Rep Biochem Mol Biol. 2020 Jul;9(2):198-208. doi: 10.29252/rbmb.9.2.199.