PMID- 33181840
OWN - NLM
STAT- MEDLINE
DCOM- 20201116
LR  - 20201116
IS  - 1053-4628 (Print)
IS  - 1053-4628 (Linking)
VI  - 44
IP  - 5
DP  - 2020 Sep 1
TI  - Enhanced Fluoride Bioavailability with Incorporation of Arginine in Child 
      Dentifrices.
PG  - 332-341
LID - 10.17796/1053-4625-44.5.7 [doi]
AB  - OBJECTIVE(S): To: 1) examine the fluoride concentrations in commercial child 
      formula dentifrices (CFD)s; and 2) investigate the effect of arginine 
      incorporation in CFDs on fluoride bioavailability. STUDY DESIGN: Five commercial 
      CFDs were examined for fluoride concentrations. Total, total soluble, and 
      insoluble fluorides in CFDs were determined by the modified Taves acid-diffusion 
      method (TAD). Ionic F and MFP were estimated by modified direct method with 
      standard addition technique. L-arginine (L-Arg)/L-arginine monohydrochloride 
      (L-Arg.HCl) were incorporated at 2% w/w in the commercial CFDs. The pH of the 
      toothpaste slurries, buffer capacity of the added Arg, potentially available 
      fluorides (PAF) and 1-min PAF by TAD were determined. RESULTS: The CFDs had 4 to 
      32% of insoluble fluorides. Addition of L-Arg/L-Arg.HCl significantly improved 
      the fluoride bioavailability in CFDs (p<0.05). Incorporation of L-Arg 
      significantly increased the pH of toothpaste slurries (p<0.05); while L-Arg.HCl 
      decreased the pH. Principal component analysis showed that L-Arg.HCl decreased 
      the pH of toothpaste slurries due to the presence of Cl in the form of HCl; 
      whereas the inherent elements/molecules (Na/P/Pi/F) remain distinct with 
      unidentified influence on the variables. CONCLUSION(S): The CFDs containing NaF 
      only have higher concentrations of bioavailable fluoride. Incorporating arginine 
      (L-arginine or L-arginine monohydrochloride) at 2% w/w improves fluoride 
      bioavailability of the child formula dentifrices.
FAU - Bijle, Mohammed Nadeem
AU  - Bijle MN
FAU - Tsoi, James
AU  - Tsoi J
FAU - Ekambaram, Manikandan
AU  - Ekambaram M
FAU - Lo, Edward C M
AU  - Lo ECM
FAU - Carey, Clifton M
AU  - Carey CM
FAU - Yiu, Cynthia Kar Yung
AU  - Yiu CKY
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - J Clin Pediatr Dent
JT  - The Journal of clinical pediatric dentistry
JID - 9100079
RN  - 0 (Cariostatic Agents)
RN  - 0 (Dentifrices)
RN  - 0 (Phosphates)
RN  - 0 (Toothpastes)
RN  - 8ZYQ1474W7 (Sodium Fluoride)
RN  - 94ZLA3W45F (Arginine)
RN  - Q80VPU408O (Fluorides)
MH  - Arginine
MH  - Biological Availability
MH  - Cariostatic Agents
MH  - Child
MH  - *Dentifrices
MH  - *Fluorides
MH  - Humans
MH  - Phosphates
MH  - Sodium Fluoride
MH  - Toothpastes
OTO - NOTNLM
OT  - Arginine
OT  - bioavailability
OT  - child
OT  - dentifrices
OT  - fluorides
EDAT- 2020/11/13 06:00
MHDA- 2020/11/18 06:00
CRDT- 2020/11/12 20:17
PHST- 2020/11/12 20:17 [entrez]
PHST- 2020/11/13 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
AID - 447334 [pii]
AID - 10.17796/1053-4625-44.5.7 [doi]
PST - ppublish
SO  - J Clin Pediatr Dent. 2020 Sep 1;44(5):332-341. doi: 10.17796/1053-4625-44.5.7.