PMID- 33182091
OWN - NLM
STAT- MEDLINE
DCOM- 20201127
LR  - 20240214
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 262
DP  - 2021 Jan
TI  - Associations of PCBS, dioxins and furans with follicle-stimulating hormone and 
      luteinizing hormone in postmenopausal women: National Health and Nutrition 
      Examination Survey 1999-2002.
PG  - 128309
LID - S0045-6535(20)32504-2 [pii]
LID - 10.1016/j.chemosphere.2020.128309 [doi]
AB  - BACKGROUND: The general population is exposed to the group of endocrine 
      disrupting chemicals persistent organic pollutants (POPs), that includes 
      polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and 
      polychlorinated dibenzofurans (PCDFs). OBJECTIVES: The aim of this research was 
      to evaluate the associations of serum levels of PCB, PCDD, and PCDF congeners 
      with follicle stimulating hormone (FSH) and luteinizing hormone (LH) in 
      postmenopausal women not taking exogenous hormones. We hypothesized that 
      associations of POPs with these gonadotropins could be modified by factors 
      affecting endogenous hormones. METHODS: Cross-sectional analyses were conducted 
      on data from 89 postmenopausal women using data from the National Health and 
      Nutrition Examination Survey (NHANES). POPs were summarized based on 
      classification schemes thought to reflect toxicological properties. Associations 
      of POPs and gonadotropin hormones were modeled with multivariable regression 
      models. When evidence of interaction was found, conditional effects were 
      estimated. RESULTS: We found inverse associations of LH, but not FSH, with 
      exposure to anti-estrogenic and/or dioxin-like POPs, but not with non dioxin-like 
      PCBs. A doubling of dioxin-like toxic equivalents (TEQs) was associated with a 
      decrease in LH of 11.9% (95% CI = -21.3%, -1.4%, p = 0.03). Inverse associations 
      were enhanced by potential effect modifiers related to both direct and indirect 
      estrogenicity, including obesity and the obesity-related condition inflammation. 
      CONCLUSIONS: These investigations support a pattern of endocrine-disrupting 
      effects by dioxin-like POPs among postmenopausal women, especially those with 
      conditions related to peripheral estrogenicity.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Lambertino, Anissa
AU  - Lambertino A
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois at Chicago, Chicago, IL, USA.
FAU - Persky, Victoria
AU  - Persky V
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois at Chicago, Chicago, IL, USA.
FAU - Freels, Sally
AU  - Freels S
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois at Chicago, Chicago, IL, USA.
FAU - Anderson, Henry
AU  - Anderson H
AD  - University of Wisconsin-Madison, Population Health Sciences, Madison, WI, USA.
FAU - Unterman, Terry
AU  - Unterman T
AD  - Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, 
      College of Medicine, University of Illinois at Chicago, Chicago, IL, USA; Jesse 
      Brown VA Medical Center, Chicago, IL, USA.
FAU - Awadalla, Saria
AU  - Awadalla S
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois at Chicago, Chicago, IL, USA.
FAU - Turyk, Mary
AU  - Turyk M
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois at Chicago, Chicago, IL, USA. Electronic address: mturyk1@uic.edu.
LA  - eng
GR  - P30 ES027792/ES/NIEHS NIH HHS/United States
GR  - T42OH008672/ACL/ACL HHS/United States
PT  - Journal Article
DEP - 20200911
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Dibenzofurans, Polychlorinated)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Dibenzofurans, Polychlorinated/*analysis
MH  - Endocrine Disruptors/*analysis
MH  - Environmental Pollutants/*analysis
MH  - Female
MH  - Follicle Stimulating Hormone/*blood
MH  - Humans
MH  - Luteinizing Hormone/*blood
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Polychlorinated Biphenyls/*analysis
MH  - Polychlorinated Dibenzodioxins/*analysis
MH  - Postmenopause/*blood
MH  - United States
PMC - PMC7670081
MID - NIHMS1632893
OTO - NOTNLM
OT  - Dioxins
OT  - Endocrine disruption
OT  - Follicle stimulating hormone
OT  - Luteinizing hormone
OT  - PCBs
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/11/14 06:00
MHDA- 2020/11/28 06:00
PMCR- 2022/01/01
CRDT- 2020/11/13 01:01
PHST- 2020/08/01 00:00 [received]
PHST- 2020/09/01 00:00 [revised]
PHST- 2020/09/09 00:00 [accepted]
PHST- 2020/11/13 01:01 [entrez]
PHST- 2020/11/14 06:00 [pubmed]
PHST- 2020/11/28 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - S0045-6535(20)32504-2 [pii]
AID - 10.1016/j.chemosphere.2020.128309 [doi]
PST - ppublish
SO  - Chemosphere. 2021 Jan;262:128309. doi: 10.1016/j.chemosphere.2020.128309. Epub 
      2020 Sep 11.