PMID- 33183028
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 10
IP  - 2
DP  - 2021 Feb
TI  - Evaluation of maternal and fetal outcomes in pregnancy complicated with pulmonary 
      arterial hypertension.
PG  - 1404-1410
LID - 10.21037/apm-20-551 [doi]
AB  - BACKGROUND: Pulmonary arterial hypertension (PAH) is an uncommon type of 
      pulmonary hypertension (PH) disease characterized by progressive remodeling of 
      distal pulmonary arteries. It could inevitably lead to pulmonary vascular 
      resistance and even right ventricular failure. Biologists have explored the basic 
      pathobiology of PAH, but its functional mechanism and effect in pregnant people 
      remain unknown. This study was designed to investigate the maternal and fetal 
      outcomes of pregnancy-related PAH. METHODS: Clinical data of 59 pregnant women 
      with PAH who were admitted to Peking Union Medical College Hospital from Jan. 
      2000 to Dec. 2018 were retrospectively reviewed and analyzed. Multiple 
      parameters, including age, gestational week, the New York Heart Association 
      (NYHA) cardiac functional classification, ultrasonic cardiogram (UCG), blood 
      test, pregnancy complications, pulmonary arterial systolic pressure, maternal and 
      fetal outcomes, were comprehensively investigated and analyzed. RESULTS: 
      According to the pulmonary arterial systolic pressure, all 59 pregnant women were 
      divided into mild PAH (30-49 mmHg, n=18), moderate PAH (50-79 mmHg, n=17) and 
      severe PAH (>79 mmHg, n=24). Five patients died, and the mortality rate was 8.5%. 
      Compared with the mild and moderate groups, the mean gestational week, age of the 
      pregnancy, and NYHA cardiac functional classification grade in the severe PAH 
      group were dramatically different (all P<0.05). The incidence of 
      pregnancy-related complications in the severe PAH group was significantly higher 
      than those in the mild and moderate PAH groups (both P<0.05). CONCLUSIONS: The 
      blood parameters, PAH, and NYHA cardiac functional classification grade were 
      significantly changed before and after surgery. We found that the severity of PAH 
      was a major factor of maternal and fetal outcomes. Strengthening the nursing care 
      for pregnant women with PAH is of great clinical significance.
FAU - Zhou, Qian
AU  - Zhou Q
AD  - Department of Obstertrics and Gynaecology, Peking Union Medical College Hospital, 
      Beijing, China.
FAU - Peng, Ping
AU  - Peng P
AD  - Department of Obstertrics and Gynaecology, Peking Union Medical College Hospital, 
      Beijing, China. pengping2164@sina.com.
FAU - Liu, Xinyan
AU  - Liu X
AD  - Department of Obstertrics and Gynaecology, Peking Union Medical College Hospital, 
      Beijing, China.
FAU - Liu, Juntao
AU  - Liu J
AD  - Department of Obstertrics and Gynaecology, Peking Union Medical College Hospital, 
      Beijing, China.
FAU - Gao, Jinsong
AU  - Gao J
AD  - Department of Obstertrics and Gynaecology, Peking Union Medical College Hospital, 
      Beijing, China.
FAU - Chen, Weilin
AU  - Chen W
AD  - Department of Obstertrics and Gynaecology, Peking Union Medical College Hospital, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20201029
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
SB  - IM
MH  - Cesarean Section
MH  - Familial Primary Pulmonary Hypertension
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - *Pulmonary Arterial Hypertension
MH  - Retrospective Studies
OTO - NOTNLM
OT  - NYHA functional classification
OT  - Pulmonary arterial hypertension (PAH)
OT  - maternal and fetal outcome
OT  - pregnancy
OT  - severity
EDAT- 2020/11/14 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/11/13 05:31
PHST- 2020/03/05 00:00 [received]
PHST- 2020/08/19 00:00 [accepted]
PHST- 2020/11/14 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/11/13 05:31 [entrez]
AID - apm-20-551 [pii]
AID - 10.21037/apm-20-551 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2021 Feb;10(2):1404-1410. doi: 10.21037/apm-20-551. Epub 2020 
      Oct 29.