PMID- 33183606
OWN - NLM
STAT- MEDLINE
DCOM- 20210408
LR  - 20210408
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 252
DP  - 2021 Jan 15
TI  - Friend or foe? The roles of inulin-type fructans.
PG  - 117155
LID - S0144-8617(20)31328-X [pii]
LID - 10.1016/j.carbpol.2020.117155 [doi]
AB  - Inulin-type fructans (ITFs) as functional fructans and soluble dietary fiber are 
      a mixture of inulin, oligofructose and fructooligosaccharide with beta 
      configuration. They are modified by gut microbiota at the end of ileum, 
      subsequently, improve digestive system, metabolic syndrome, immune system and 
      inflammatory diseases, and prevent against infection and cancer. However, it has 
      been reported that inadequate consumption of ITFs aggravates the development of 
      non-alcoholic fatty liver disease, results in gastrointestinal symptoms, liver 
      cancer and intestinal inflammation. Therefore, this review summarizes the health 
      benefits, pharmaceutical applications and safety evaluation of ITFs, which would 
      direct their rational applications.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Man, Shuli
AU  - Man S
AD  - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial 
      Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry 
      Microbiology, National and Local United Engineering Lab of Metabolic Control 
      Fermentation Technology, China International Science and Technology Cooperation 
      Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, 
      Tianjin University of Science & Technology, Tianjin, 300457, China. Electronic 
      address: msl@tust.edu.cn.
FAU - Liu, Taohua
AU  - Liu T
AD  - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial 
      Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry 
      Microbiology, National and Local United Engineering Lab of Metabolic Control 
      Fermentation Technology, China International Science and Technology Cooperation 
      Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, 
      Tianjin University of Science & Technology, Tianjin, 300457, China.
FAU - Yao, Yuan
AU  - Yao Y
AD  - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial 
      Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry 
      Microbiology, National and Local United Engineering Lab of Metabolic Control 
      Fermentation Technology, China International Science and Technology Cooperation 
      Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, 
      Tianjin University of Science & Technology, Tianjin, 300457, China.
FAU - Lu, Yingying
AU  - Lu Y
AD  - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial 
      Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry 
      Microbiology, National and Local United Engineering Lab of Metabolic Control 
      Fermentation Technology, China International Science and Technology Cooperation 
      Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, 
      Tianjin University of Science & Technology, Tianjin, 300457, China.
FAU - Ma, Long
AU  - Ma L
AD  - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial 
      Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry 
      Microbiology, National and Local United Engineering Lab of Metabolic Control 
      Fermentation Technology, China International Science and Technology Cooperation 
      Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, 
      Tianjin University of Science & Technology, Tianjin, 300457, China.
FAU - Lu, Fuping
AU  - Lu F
AD  - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial 
      Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry 
      Microbiology, National and Local United Engineering Lab of Metabolic Control 
      Fermentation Technology, China International Science and Technology Cooperation 
      Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, 
      Tianjin University of Science & Technology, Tianjin, 300457, China. Electronic 
      address: lfp@tust.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201001
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Dietary Fiber)
RN  - 9005-80-5 (Inulin)
SB  - IM
MH  - Animals
MH  - Colitis/*chemically induced
MH  - Dietary Fiber/*adverse effects
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Humans
MH  - Inflammation/*chemically induced
MH  - Inulin/*analogs & derivatives
MH  - Liver Neoplasms/*chemically induced
OTO - NOTNLM
OT  - Acute colitis
OT  - Acute laminitis
OT  - ITFs (DP = 10), PubChem CID 138911433, PubChem CID 35394686, PubChem CID 
      138108150
OT  - ITFs (DP = 11), PubChem CID 131674907
OT  - ITFs (DP = 12), PubChem CID 138392202
OT  - ITFs (DP = 3), PubChem CID 16219508
OT  - ITFs (DP = 38), PubChem CID 24763, PubChem CID 18772499
OT  - ITFs (DP = 7), PubChem CID 50938613
OT  - ITFs (DP = 8), PubChem CID 135394093
OT  - ITFs (DP = 9), PubChem CID 91856744
OT  - Intestinal flora
OT  - Inulin-type fructans
OT  - Short-chain fatty acids
EDAT- 2020/11/14 06:00
MHDA- 2021/04/10 06:00
CRDT- 2020/11/13 05:34
PHST- 2020/07/29 00:00 [received]
PHST- 2020/09/11 00:00 [revised]
PHST- 2020/09/25 00:00 [accepted]
PHST- 2020/11/13 05:34 [entrez]
PHST- 2020/11/14 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
AID - S0144-8617(20)31328-X [pii]
AID - 10.1016/j.carbpol.2020.117155 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2021 Jan 15;252:117155. doi: 10.1016/j.carbpol.2020.117155. Epub 
      2020 Oct 1.