PMID- 33183638
OWN - NLM
STAT- MEDLINE
DCOM- 20210412
LR  - 20210412
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 252
DP  - 2021 Jan 15
TI  - Inclusion complex based on N-acetyl-L-cysteine and arginine modified 
      hydroxypropyl-beta-cyclodextrin for oral insulin delivery.
PG  - 117202
LID - S0144-8617(20)31375-8 [pii]
LID - 10.1016/j.carbpol.2020.117202 [doi]
AB  - Insulin is the most effective drug in the treatment of diabetes mellitus. At 
      present, subcutaneous injection is still the common way for insulin delivery. 
      However, oral delivery is considered as the most preferred way for its high 
      patient compliance and the minimal invasiveness. In this study, a novel 
      N-acetyl-L-cysteine and arginine modified hydroxypropyl-beta-cyclodextrin 
      (NAC-HP-beta-CD-Arg) was successfully synthesized and characterized. The polymer was 
      used as a carrier for oral delivery of insulin by forming NAC-HP-beta-CD-Arg@insulin 
      complex. Enzymatic degradation study indicated that the NAC-HP-beta-CD-Arg could 
      protect insulin from enzymolysis. Moreover, the polymer exhibited strong binding 
      ability with mucin. The transportation efficiency of NAC-HP-beta-CD-Arg@insulin 
      across the Caco-2 cell monolayer was much greater than free insulin. The in vivo 
      study demonstrated that the orally administered NAC-HP-beta-CD-Arg@insulin exhibited 
      an excellent and sustained hypoglycemic effect in diabetic rats. It can be 
      concluded that the NAC-HP-beta-CD-Arg is a potential carrier for oral delivery of 
      insulin.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Li, Siyi
AU  - Li S
AD  - Key Laboratory of Functional Inorganic Materials Chemistry (Ministry of 
      Education), School of Chemistry and Material Science, Heilongjiang University, 
      Harbin 150080, China. Electronic address: lisiyi626@163.com.
FAU - Liang, Na
AU  - Liang N
AD  - College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 
      150025, China. Electronic address: liangna528@163.com.
FAU - Yan, Pengfei
AU  - Yan P
AD  - Key Laboratory of Functional Inorganic Materials Chemistry (Ministry of 
      Education), School of Chemistry and Material Science, Heilongjiang University, 
      Harbin 150080, China. Electronic address: yanpf@vip.sina.com.
FAU - Kawashima, Yoshiaki
AU  - Kawashima Y
AD  - Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin 
      University, Nagoya 464-8650, Japan. Electronic address: sykawa123@163.com.
FAU - Sun, Shaoping
AU  - Sun S
AD  - Key Laboratory of Functional Inorganic Materials Chemistry (Ministry of 
      Education), School of Chemistry and Material Science, Heilongjiang University, 
      Harbin 150080, China. Electronic address: sunshaoping111@163.com.
LA  - eng
PT  - Journal Article
DEP - 20201010
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Drug Carriers)
RN  - 0 (Excipients)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 1I96OHX6EK (2-Hydroxypropyl-beta-cyclodextrin)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - 2-Hydroxypropyl-beta-cyclodextrin/*chemistry
MH  - Acetylcysteine/*chemistry
MH  - Administration, Oral
MH  - Animals
MH  - Caco-2 Cells
MH  - Diabetes Mellitus, Experimental/*drug therapy
MH  - Drug Carriers/*chemistry
MH  - Excipients/*chemistry
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage
MH  - Insulin/*administration & dosage
MH  - Male
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Arginine
OT  - Hydroxypropyl-beta-cyclodextrin
OT  - Insulin
OT  - N-acetyl-L-cysteine
OT  - Oral delivery
EDAT- 2020/11/14 06:00
MHDA- 2021/04/13 06:00
CRDT- 2020/11/13 05:34
PHST- 2020/05/23 00:00 [received]
PHST- 2020/09/17 00:00 [revised]
PHST- 2020/10/05 00:00 [accepted]
PHST- 2020/11/13 05:34 [entrez]
PHST- 2020/11/14 06:00 [pubmed]
PHST- 2021/04/13 06:00 [medline]
AID - S0144-8617(20)31375-8 [pii]
AID - 10.1016/j.carbpol.2020.117202 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2021 Jan 15;252:117202. doi: 10.1016/j.carbpol.2020.117202. Epub 
      2020 Oct 10.