PMID- 33183665
OWN - NLM
STAT- MEDLINE
DCOM- 20210706
LR  - 20210706
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 54
DP  - 2020 Nov
TI  - The Effect of Lactobacillus Consumption on Human Blood Pressure: a Systematic 
      Review and Meta-Analysis of Randomized Controlled Trials.
PG  - 102547
LID - S0965-2299(20)31814-8 [pii]
LID - 10.1016/j.ctim.2020.102547 [doi]
AB  - OBJECTIVES: Previous clinical studies have shown controversial results regarding 
      the effect of Lactobacillus supplementation on blood pressure (BP). The purpose 
      of this systematic review and meta-analysis is to examine the effect of 
      Lactobacillus consumption on BP. METHODS: Eligible randomized controlled trials 
      (RCTs) were searched from five electronic databases until May 2020. In total, 18 
      studies were included in our meta-analysis. Quality of the selected studies was 
      assessed, and a random-effects model was used to calculate the overall effect 
      sizes of weighted mean differences (WMD). This systematic review was registered 
      in PROSPERO with the number: CRD42019139294. RESULTS: Lactobacillus consumption 
      significantly reduced systolic blood pressure (SBP) by -2.74 mmHg (95% confidence 
      interval, -4.96 to -0.51) and diastolic blood pressure (DBP) by -1.50 mmHg (95% 
      confidence interval, -2.44 to -0.56) when comparing with the control group. 
      Subgroup analysis showed that type 2 diabetes mellitus (T2DM) patients, Asian 
      individuals, or borderline hypertension participants were more sensitive to daily 
      consumption of Lactobacillus. And the effect of Lactobacillus on BP-reduction was 
      more significant in capsule form, with the dose was above 5 x 10(9) 
      colony-forming unit (CFU)/day or lasted for more than 8 weeks. CONCLUSIONS: Our 
      present study suggests that Lactobacillus consumption in capsule form when the 
      daily dose is above 5 x 10(9) CFU for more than 8 weeks can decrease SBP or DBP 
      in T2DM patients, borderline hypertension participants or Asian individuals.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Liu, Jinshu
AU  - Liu J
AD  - Nursing school of Jilin University, Changchun, Jilin, 130021, China. Electronic 
      address: jsliu1226@foxmail.com.
FAU - Zhang, Dan
AU  - Zhang D
AD  - Nursing school of Jilin University, Changchun, Jilin, 130021, China. Electronic 
      address: danzhang01@foxmail.com.
FAU - Guo, Yingze
AU  - Guo Y
AD  - The first hospital of Jilin University, Changchun, Jilin, 130021, China. 
      Electronic address: glr248@163.com.
FAU - Cai, Hongwei
AU  - Cai H
AD  - Nursing school of Jilin University, Changchun, Jilin, 130021, China. Electronic 
      address: cai1002741397@foxmail.com.
FAU - Liu, Keyuan
AU  - Liu K
AD  - Basic College of Medical Sciences, Jilin University, Changchun, Jilin, 130021, 
      China. Electronic address: 18243054065@163.com.
FAU - He, Yayu
AU  - He Y
AD  - Nursing school of Jilin University, Changchun, Jilin, 130021, China. Electronic 
      address: 18838986180@163.com.
FAU - Liu, Yumo
AU  - Liu Y
AD  - Nursing school of Jilin University, Changchun, Jilin, 130021, China. Electronic 
      address: 18843148523@163.com.
FAU - Guo, Lirong
AU  - Guo L
AD  - Nursing school of Jilin University, Changchun, Jilin, 130021, China. Electronic 
      address: guolr@jlu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200902
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
SB  - IM
MH  - Blood Pressure/*drug effects
MH  - Humans
MH  - Hypertension/drug therapy
MH  - *Lactobacillus
MH  - Probiotics/*administration & dosage
MH  - Randomized Controlled Trials as Topic
EDAT- 2020/11/14 06:00
MHDA- 2021/07/07 06:00
CRDT- 2020/11/13 05:36
PHST- 2020/03/04 00:00 [received]
PHST- 2020/07/19 00:00 [revised]
PHST- 2020/08/24 00:00 [accepted]
PHST- 2020/11/13 05:36 [entrez]
PHST- 2020/11/14 06:00 [pubmed]
PHST- 2021/07/07 06:00 [medline]
AID - S0965-2299(20)31814-8 [pii]
AID - 10.1016/j.ctim.2020.102547 [doi]
PST - ppublish
SO  - Complement Ther Med. 2020 Nov;54:102547. doi: 10.1016/j.ctim.2020.102547. Epub 
      2020 Sep 2.