PMID- 33184057
OWN - NLM
STAT- MEDLINE
DCOM- 20211109
LR  - 20211109
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 69
IP  - 1
DP  - 2021 Jan
TI  - Serum granzyme B is associated with otorhinolaryngological, pulmonary, and renal 
      involvement of antineutrophil cytoplasmic antibody-associated vasculitis.
PG  - 91-95
LID - 10.1136/jim-2020-001365 [doi]
AB  - We investigated whether serum granzyme B (GrB) can reflect the inflammatory 
      burden such as cross-sectional disease activity and organ-specific involvement in 
      immunosuppressive drug-naive patients with antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV). Seventy-eight immunosuppressive drug-naive 
      patients with AAV were included in this study. At the time of the first 
      classification, whole blood was obtained from each patient and sera was 
      immediately isolated and stored at - 80℃. On the day of the blood sampling, we 
      performed routine laboratory tests including antineutrophil cytoplasmic antibody 
      tests and collected both clinical and laboratory data. AAV-specific indices 
      included Birmingham Vasculitis Activity Score (BVAS) and Five-Factor Score (FFS). 
      The median age of patients with AAV was 62 years and 26 patients were men. Serum 
      GrB was not associated with the cross-sectional BVAS; however, patients with 
      serum GrB positivity exhibited higher frequencies of otorhinolaryngological 
      manifestation than those without (p=0.037). When serum GrB levels were compared 
      after dividing the patients into two groups based on the presence of 
      organ-specific involvement, patients with pulmonary involvement exhibited a 
      significantly higher serum GrB than those without (p=0.042). On the other hand, 
      patients with renal involvement showed a significantly lower serum GrB than those 
      without (p=0.023). In addition, serum GrB was inversely correlated with the 
      cross-sectional FFS (r=-0.249, p=0.028). Even though serum GrB could not reflect 
      the inflammatory burden of AAV, serum GrB was associated with 
      otorhinolaryngological, pulmonary, and renal involvement in immunosuppressive 
      drug-naive patients with AAV.
CI  - (c) American Federation for Medical Research 2021. No commercial re-use. See rights 
      and permissions. Published by BMJ.
FAU - Yoon, Taejun
AU  - Yoon T
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea (the Republic of).
FAU - Yoo, Juyoung
AU  - Yoo J
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea (the Republic of).
FAU - Ahn, Sung Soo
AU  - Ahn SS
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea (the Republic of).
FAU - Song, Jason Jungsik
AU  - Song JJ
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea (the Republic of).
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea (the Republic of).
FAU - Park, Yong-Beom
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea (the Republic of).
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea (the Republic of).
FAU - Lee, Sang-Won
AU  - Lee SW
AUID- ORCID: 0000-0002-8038-3341
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea (the Republic of) sangwonlee@yuhs.ac.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea (the Republic of).
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20201112
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (Biomarkers)
RN  - EC 3.4.21.- (GZMB protein, human)
RN  - EC 3.4.21.- (Granzymes)
SB  - IM
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*blood
MH  - Biomarkers/blood
MH  - Female
MH  - Granzymes/*blood
MH  - Humans
MH  - Inflammation/*blood
MH  - Kidney Diseases
MH  - Lung Diseases
MH  - Male
MH  - Middle Aged
MH  - Otorhinolaryngologic Diseases
MH  - Prospective Studies
OTO - NOTNLM
OT  - autoimmune diseases
OT  - biomarkers
OT  - vascular diseases
COIS- Competing interests: None declared.
EDAT- 2020/11/14 06:00
MHDA- 2021/11/10 06:00
CRDT- 2020/11/13 05:44
PHST- 2020/10/27 00:00 [accepted]
PHST- 2020/11/14 06:00 [pubmed]
PHST- 2021/11/10 06:00 [medline]
PHST- 2020/11/13 05:44 [entrez]
AID - jim-2020-001365 [pii]
AID - 10.1136/jim-2020-001365 [doi]
PST - ppublish
SO  - J Investig Med. 2021 Jan;69(1):91-95. doi: 10.1136/jim-2020-001365. Epub 2020 Nov 
      12.