PMID- 33184206 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20201209 LR - 20201214 IS - 1095-9203 (Electronic) IS - 0036-8075 (Linking) VI - 370 IP - 6518 DP - 2020 Nov 13 TI - New refrigerants and system configurations for vapor-compression refrigeration. PG - 791-796 LID - 10.1126/science.abe3692 [doi] AB - The high global warming potential of current refrigerants in cooling equipment based on the vapor-compression cycle has triggered a major effort to find and implement more environmentally benign alternatives. Here, we review the basics of the vapor-compression cycle together with the safety, environmental, and thermodynamic constraints that have led to the current and next generation of refrigerants. The development of new fluids has focused on fluorinated olefins, known as hydrofluoroolefins (HFOs), and blends that contain HFOs. Many of these are slightly flammable, presenting trade-offs between safety and environmental considerations. Engineers also have options with a resurgence of the "natural refrigerants" (ammonia, carbon dioxide, propane, and isobutane). Innovative system designs that reduce the required quantity of refrigerant may allow a wider choice of refrigerants. CI - Copyright (c) 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. FAU - McLinden, Mark O AU - McLinden MO AUID- ORCID: 0000-0002-1082-309X AD - Applied Chemicals and Materials Division, National Institute of Standards and Technology, Boulder, CO 80305, USA. mark.mclinden@nist.gov. FAU - Seeton, Christopher J AU - Seeton CJ AD - Shrieve Chemical Products, The Woodlands, TX 77380, USA. FAU - Pearson, Andy AU - Pearson A AUID- ORCID: 0000-0001-8096-8924 AD - Star Refrigeration, Glasgow, Scotland, UK. LA - eng PT - Journal Article PT - Review PL - United States TA - Science JT - Science (New York, N.Y.) JID - 0404511 SB - IM EDAT- 2020/11/14 06:00 MHDA- 2020/11/14 06:01 CRDT- 2020/11/13 05:45 PHST- 2020/11/13 05:45 [entrez] PHST- 2020/11/14 06:00 [pubmed] PHST- 2020/11/14 06:01 [medline] AID - 370/6518/791 [pii] AID - 10.1126/science.abe3692 [doi] PST - ppublish SO - Science. 2020 Nov 13;370(6518):791-796. doi: 10.1126/science.abe3692.