PMID- 33185160
OWN - NLM
STAT- MEDLINE
DCOM- 20210803
LR  - 20211204
IS  - 1875-5607 (Electronic)
IS  - 1389-5575 (Linking)
VI  - 21
IP  - 7
DP  - 2021
TI  - The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine 
      Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A 
      Narrative Review.
PG  - 803-815
LID - 10.2174/1389557520666201113110406 [doi]
AB  - BACKGROUND: The mammalian target of rapamycin (mTOR), protein tyrosine 
      phosphatase 1b (PTP1B) and dipeptidase 4 (DPP4) signaling pathways regulate 
      eukaryotic cell proliferation and metabolism. Previous researches described 
      different transduction mechanisms in the progression of cancer and diabetes. 
      METHODOLOGY: We reviewed recent advances in the signal transduction pathways of 
      mTOR, PTP1B and DPP4 regulation and determined the crosstalk and common pathway 
      in diabetes and cancer. RESULTS: We showed that according to numerous past 
      studies, the proteins participate in the signaling networks for both diseases. 
      CONCLUSION: There are common pathways and specific proteins involved in diabetes 
      and cancer. This article demonstrates and explains the potential mechanisms of 
      association and future prospects for targeting these proteins in pharmacological 
      studies.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Zhang, Jiajia
AU  - Zhang J
AD  - Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese 
      Academy of Sciences, Qingdao, Shandong, China.
FAU - Wu, Ning
AU  - Wu N
AD  - Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese 
      Academy of Sciences, Qingdao, Shandong, China.
FAU - Shi, Dayong
AU  - Shi D
AD  - Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese 
      Academy of Sciences, Qingdao, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Mini Rev Med Chem
JT  - Mini reviews in medicinal chemistry
JID - 101094212
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.15.- (peptidyl dipeptidase 4)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus/*metabolism
MH  - Endopeptidases/*metabolism
MH  - Humans
MH  - Neoplasms/*metabolism
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Signaling pathway
OT  - cancer
OT  - diabetes
OT  - dipeptidase 4
OT  - mammalian target of rapamycin
OT  - pharmacology
OT  - protein tyrosine phosphatase 1b
OT  - target compounds
EDAT- 2020/11/14 06:00
MHDA- 2021/08/04 06:00
CRDT- 2020/11/13 08:36
PHST- 2020/01/12 00:00 [received]
PHST- 2020/05/30 00:00 [revised]
PHST- 2020/07/20 00:00 [accepted]
PHST- 2020/11/14 06:00 [pubmed]
PHST- 2021/08/04 06:00 [medline]
PHST- 2020/11/13 08:36 [entrez]
AID - MRMC-EPUB-111493 [pii]
AID - 10.2174/1389557520666201113110406 [doi]
PST - ppublish
SO  - Mini Rev Med Chem. 2021;21(7):803-815. doi: 10.2174/1389557520666201113110406.