PMID- 33185219
OWN - NLM
STAT- MEDLINE
DCOM- 20210324
LR  - 20210324
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 8
IP  - 48
DP  - 2020 Dec 23
TI  - A new type of magnetic molecular imprinted material combined with beta-cyclodextrin 
      for the selective adsorption of zearalenone.
PG  - 10966-10976
LID - 10.1039/d0tb02146f [doi]
AB  - In this paper, a new magnetic molecular imprinted polymer-cyclodextrin (MMIP-CD) 
      material was prepared by connecting beta-cyclodextrin (CD) on the surface of a 
      magnetic molecular imprinted polymer (MMIP) and used for the rapid and specific 
      adsorption of zearalenone (ZEN). By using warfarin as the virtual template 
      molecule, tetraethyl orthosilicate (TEOS) as the crosslinking agent, and 
      (3-aminopropyl) triethoxysilane (APTES) as the functional monomer, a MMIP was 
      produced by surface imprinting technology. Sulfobutyl ether-beta-cyclodextrin 
      attached to the surface of the MMIP under heating conditions produced a new 
      specific adsorption material with exceptional adsorption capacity and excellent 
      selectivity for ZEN. Scanning electron microscopy (SEM), transmission electron 
      microscopy (TEM) and TEM-mapping results showed that the prepared MMIP-CD had a 
      uniform particle size of about 480 nm, and the molecularly imprinted layer was 
      successfully wrapped on the surface of the nanoparticles with a thickness of 
      about 50 nm, whereby the cyclodextrin was effectively attached to the surface of 
      the MMIP. The adsorption mechanism of MMIP-CD was confirmed by kinetic adsorption 
      and thermodynamic adsorption experiments, the maximum adsorption capacity was 
      found to be about 30 mg g-1, and the adsorption equilibrium could be reached 
      within 20 min. The value of IF (QMMIP-CD/QMNIP) is 4.642. This showed that 
      compared with MNIP, MMIP-CD showed a greatly improved specific adsorption 
      capacity of ZEN. Selective experiments proved that MMIP-CD effectively combined 
      the advantages of MMIP and CD, enhancing the adsorption capacity together with 
      reducing the disadvantages that MMIP cannot distinguish structural analogs and CD 
      cannot identify hydrophobic compounds effectively. In actual sample testing, the 
      limit of quantification (LOQ) and limit of detection (LOD) were 0.1 ng kg-1 and 
      0.3 ng kg-1, respectively. The stability and detection precision of this method 
      were 0.98-2.76% and 1.67-3.88%, respectively. The results proved that MMIP-CD had 
      good development potential in the field of selective adsorption of ZEN, and laid 
      the foundation for follow-up research.
FAU - Fu, Han
AU  - Fu H
AD  - College of Engineering, China Pharmaceutical University, No. 24 Tongjia Alley, 
      Nanjing, P. R. China. cpucgt@cpu.edu.cn.
FAU - Liu, Junping
AU  - Liu J
AD  - College of Engineering, China Pharmaceutical University, No. 24 Tongjia Alley, 
      Nanjing, P. R. China. cpucgt@cpu.edu.cn.
FAU - Xu, Wu
AU  - Xu W
AD  - College of Engineering, China Pharmaceutical University, No. 24 Tongjia Alley, 
      Nanjing, P. R. China. cpucgt@cpu.edu.cn.
FAU - Wang, Haixiang
AU  - Wang H
AD  - College of Engineering, China Pharmaceutical University, No. 24 Tongjia Alley, 
      Nanjing, P. R. China. cpucgt@cpu.edu.cn.
FAU - Liao, Shenghua
AU  - Liao S
AUID- ORCID: 0000-0002-8921-0260
AD  - School of Science, China Pharmaceutical University, No. 24 Tongjia Alley, 
      Nanjing, P. R. China.
FAU - Chen, Guitang
AU  - Chen G
AUID- ORCID: 0000-0003-0258-2668
AD  - College of Engineering, China Pharmaceutical University, No. 24 Tongjia Alley, 
      Nanjing, P. R. China. cpucgt@cpu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Drug Combinations)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Ferric Compounds)
RN  - 0 (beta-Cyclodextrins)
RN  - 1K09F3G675 (ferric oxide)
RN  - 5W827M159J (Zearalenone)
SB  - IM
MH  - Adsorption
MH  - Drug Combinations
MH  - Estrogens, Non-Steroidal/metabolism
MH  - Ferric Compounds/chemical synthesis/metabolism
MH  - *Magnetic Phenomena
MH  - Molecular Imprinting/*methods
MH  - X-Ray Diffraction/methods
MH  - Zearalenone/*metabolism
MH  - beta-Cyclodextrins/*chemical synthesis/*metabolism
EDAT- 2020/11/14 06:00
MHDA- 2021/03/25 06:00
CRDT- 2020/11/13 08:36
PHST- 2020/11/14 06:00 [pubmed]
PHST- 2021/03/25 06:00 [medline]
PHST- 2020/11/13 08:36 [entrez]
AID - 10.1039/d0tb02146f [doi]
PST - ppublish
SO  - J Mater Chem B. 2020 Dec 23;8(48):10966-10976. doi: 10.1039/d0tb02146f.