PMID- 33188757
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20210603
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 198
DP  - 2021 Jul
TI  - Association between exposure to polyfluoroalkyl chemicals and increased 
      fractional exhaled nitric oxide in adults.
PG  - 110450
LID - S0013-9351(20)31347-5 [pii]
LID - 10.1016/j.envres.2020.110450 [doi]
AB  - BACKGROUND: Perfluoroalkyl chemicals (PFCs) are widely detected in the 
      environment and human body, and they have been linked to asthma and a number of 
      respiratory responses in children and mice. However, no previous studies have 
      investigated the association between exposure to PFCs and airway inflammation in 
      adults. OBJECTIVES: To evaluate the associations between serum PFCs and 
      fractional exhaled nitric oxide (FeNO), a biomarker of airway inflammation, in 
      adults. METHODS: A cross-sectional study of 3630 adults aged 20-79 years who 
      participated in the National Health and Nutrition Examination Survey (NHANES, 
      2007-2012) was conducted. Serum concentrations of five major PFCs were measured 
      using SPE-HPLC-TIS-MS/MS method, including perfluorohexane sulfonic acid (PFHxS), 
      perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane 
      sulfonic acid (PFOS), and perfluorodecanoic acid (PFDE). The detection rates of 
      them were all >85%. Weighted multivariable linear regression and Bayesian kernel 
      machine regression (BKMR) analyses were applied to examine the associations 
      between serum PFCs and FeNO. RESULTS: After adjusted for potential confounding 
      factors, linear regression analyses found that compared with their lowest 
      tertiles, highest tertiles of PFOS, PFDE and PFOA were significantly associated 
      with 5.02% (95% CI: 1.40%, 8.77%), 3.77% (95% CI: 0.30%, 7.36%) and 6.34% (95% 
      CI: 2.81%, 10.01%) increases in FeNO, respectively. The second tertile of PFNA 
      was significantly correlated with a 4.79% (95% CI: 1.41%, 8.29%) increase in FeNO 
      compared with the lowest tertile. In the BKMR analysis, the mixture effect of 
      PFCs on FeNO increased significantly when the PFC levels were at or above the 
      60th percentiles compared to those at their medians. PFOS and PFOA displayed 
      significant positive single-exposure effects on FeNO when all the other PFCs are 
      set at a particular threshold. CONCLUSIONS: This study provided preliminary 
      evidence that serum PFCs were positively associated with increased FeNO in 
      adults.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Xu, Huadong
AU  - Xu H
AD  - Department of Occupational and Environmental Health, Nagoya University Graduate 
      School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan. 
      Electronic address: xu.huadong@a.mbox.nagoya-u.ac.jp.
FAU - Mao, Yu
AU  - Mao Y
AD  - Department of Occupational and Environmental Health, Nagoya University Graduate 
      School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
FAU - Hu, Yanan
AU  - Hu Y
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, 
      Chinese Academy of Medical Sciences and Peking Union Medical College, No.288 
      Nanjing Road, Heping District, Tianjin, 300020, China.
FAU - Xu, Bucai
AU  - Xu B
AD  - The Longgang People's Hospital, Wenzhou Medical University, No.238 Longxiang 
      Road, Longgang City, Zhejiang, 325800, China. Electronic address: xbctcm@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201111
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - *Alkanesulfonic Acids/toxicity
MH  - Animals
MH  - Bayes Theorem
MH  - Caprylates
MH  - Cross-Sectional Studies
MH  - Environmental Exposure
MH  - *Environmental Pollutants/toxicity
MH  - *Fluorocarbons/toxicity
MH  - Mice
MH  - Nitric Oxide
MH  - Nutrition Surveys
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Adults
OT  - Airway inflammation
OT  - NHANES
OT  - Nitric oxide
OT  - Polyfluoroalkyl chemicals
EDAT- 2020/11/15 06:00
MHDA- 2021/06/04 06:00
CRDT- 2020/11/14 20:07
PHST- 2020/09/06 00:00 [received]
PHST- 2020/11/06 00:00 [revised]
PHST- 2020/11/07 00:00 [accepted]
PHST- 2020/11/15 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
PHST- 2020/11/14 20:07 [entrez]
AID - S0013-9351(20)31347-5 [pii]
AID - 10.1016/j.envres.2020.110450 [doi]
PST - ppublish
SO  - Environ Res. 2021 Jul;198:110450. doi: 10.1016/j.envres.2020.110450. Epub 2020 
      Nov 11.