PMID- 33189014
OWN - NLM
STAT- MEDLINE
DCOM- 20210924
LR  - 20210924
IS  - 2210-7797 (Electronic)
IS  - 2210-7789 (Linking)
VI  - 23
DP  - 2021 Mar
TI  - Glycyrrhizin potentially suppresses the inflammatory response in preeclampsia rat 
      model.
PG  - 34-40
LID - S2210-7789(20)30133-1 [pii]
LID - 10.1016/j.preghy.2020.10.007 [doi]
AB  - OBJECTIVE: The expression of high-mobility group box 1 (HMGB1) in trophoblasts is 
      elevated, which contributes to the development of preeclampsia. Thus, this study 
      aimed to investigate the effect of glycyrrhizin, a natural HMGB1 inhibitor, on 
      the development of preeclampsia. METHODS: Preeclampsia was induced in pregnant 
      Lewis rats through oral administration of L-NAME (50 mg/kg/day) on gestational 
      day (GD) 13-19. Glycyrrhizin (10, 30, or 60 mg/kg/day) was given by oral gavage 
      on GD 10-19. Systolic blood pressure (SBP), diastolic blood pressure (DBP), 
      24-hour proteinuria, live pup birth ratio, pup weight, pup body length, and 
      placental weight were measured. Also, the expression levels of inflammatory 
      factors (TNF-alpha, iNOS, IL-1, and IL-6), HMGB1, and TLR4 in the placenta or in the 
      serum were analyzed by enzyme-linked immunosorbent assay, RT-PCR, and Western 
      blot analysis. RESULTS: Glycyrrhizin significantly reduced the SBP, DBP, and 
      24-hour proteinuria on GD 16 and 20 in a dose-dependent manner and ameliorated 
      the pregnancy outcomes in preeclampsia rats. The elevated inflammatory molecule 
      levels were markedly decreased by glycyrrhizin not only in the serum but also in 
      the placenta. Moreover, the upregulated HMGB1 and TLR4 expression levels were 
      diminished by glycyrrhizin administration. CONCLUSION: This study shows that 
      glycyrrhizin could alleviate preeclampsia and the preeclampsia-associated 
      inflammatory reaction, and this effect could be attributed to HMGB1 inhibition.
CI  - Copyright (c) 2020 International Society for the Study of Hypertension in 
      Pregnancy. Published by Elsevier B.V. All rights reserved.
FAU - Liu, Fang
AU  - Liu F
AD  - Department of Obstetrics, ZIBO Central Hospital, No. 54 Gongqingtuan West Road, 
      Zhangdian District, Zibo 255036, Shandong, China.
FAU - Yang, Xiuzhi
AU  - Yang X
AD  - Department of Obstetrics, ZIBO Central Hospital, No. 54 Gongqingtuan West Road, 
      Zhangdian District, Zibo 255036, Shandong, China.
FAU - Xing, Junxiang
AU  - Xing J
AD  - Department of Obstetrics, ZIBO Central Hospital, No. 54 Gongqingtuan West Road, 
      Zhangdian District, Zibo 255036, Shandong, China.
FAU - Han, Ke
AU  - Han K
AD  - Department of Obstetrics, ZIBO Central Hospital, No. 54 Gongqingtuan West Road, 
      Zhangdian District, Zibo 255036, Shandong, China.
FAU - Sun, Yuan
AU  - Sun Y
AD  - Department of Obstetrics, ZIBO Central Hospital, No. 54 Gongqingtuan West Road, 
      Zhangdian District, Zibo 255036, Shandong, China. Electronic address: 
      suny0325@126.com.
LA  - eng
PT  - Journal Article
DEP - 20201022
PL  - Netherlands
TA  - Pregnancy Hypertens
JT  - Pregnancy hypertension
JID - 101552483
RN  - 0 (HMGB1 Protein)
RN  - 0 (Toll-Like Receptor 4)
RN  - 6FO62043WK (Glycyrrhizic Acid)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Disease Models, Animal
MH  - Female
MH  - Glycyrrhizic Acid/metabolism/*pharmacology
MH  - HMGB1 Protein/drug effects
MH  - Humans
MH  - Pre-Eclampsia/metabolism/*prevention & control
MH  - Pregnancy
MH  - Proteinuria/prevention & control
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Toll-Like Receptor 4/drug effects
OTO - NOTNLM
OT  - Glycyrrhizin
OT  - HMGB1
OT  - L-NAME
OT  - Preeclampsia
OT  - TLR4
EDAT- 2020/11/15 06:00
MHDA- 2021/09/25 06:00
CRDT- 2020/11/14 20:10
PHST- 2020/05/04 00:00 [received]
PHST- 2020/10/08 00:00 [revised]
PHST- 2020/10/16 00:00 [accepted]
PHST- 2020/11/15 06:00 [pubmed]
PHST- 2021/09/25 06:00 [medline]
PHST- 2020/11/14 20:10 [entrez]
AID - S2210-7789(20)30133-1 [pii]
AID - 10.1016/j.preghy.2020.10.007 [doi]
PST - ppublish
SO  - Pregnancy Hypertens. 2021 Mar;23:34-40. doi: 10.1016/j.preghy.2020.10.007. Epub 
      2020 Oct 22.