PMID- 33189200
OWN - NLM
STAT- MEDLINE
DCOM- 20210511
LR  - 20231112
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 72
IP  - 5
DP  - 2020 Sep-Oct
TI  - Profile of coronary artery disease in indian rural youth (< 35 yrs).
PG  - 394-397
LID - S0019-4832(20)30186-3 [pii]
LID - 10.1016/j.ihj.2020.08.002 [doi]
AB  - AIMS: To study the risk factors, clinical and angiographic profile of Indian 
      rural youth (under 35yrs) presenting with Premature Coronary Artery Disease 
      (PCAD). SUBJECTS: and Methods: The PCAD registry had 1628 patients who were aged 
      below 35 years, of which 681 patients satisfied the entry criteria. The data was 
      analysed by statistical software R version 3.5.0. RESULTS: The study enrolled 681 
      patients after satisfying the entry criteria. The mean age of patients was 30.85 
      years. There were 405 (59.5%) aged between 30 and 35 yrs, 205 (30.1%) between 25 
      and 30 yrs, 64 (9.4%) between 20 and 25 yrs and 7 (1.0%) were aged less than 20 
      yrs. Majority of them were males, 617 (90.6%). Nearly 411 (60.4%) were smokers, 
      56patients (8.2%) were diabetics and 97 (14.2%) were hypertensives. Around 441 
      (64.8%) patients had low HDL cholesterol levels and 218 (32.0%) had elevated 
      triglyceride levels. Abdominal obesity was seen in 443 (65.1%) patients. Most 
      common clinical presentation was ST elevation myocardial infarction (STEMI) seen 
      in 536 (78.7%) patients. Around 40% patients had recanalized/non 
      obstructive/thrombotic/normal coronaries on coronary angiogram. CONCLUSIONS: 
      Conventional risk factors such as smoking, low HDL levels and abdominal obesity 
      play a major role in the causation of premature coronary artery disease among the 
      rural youth. Thrombotic milieu in the coronaries was commonly noted in coronary 
      angiograms. Lack of awareness, combined with urbanisation of rural lifestyle 
      could be responsible for increasing incidence of premature coronary artery 
      disease in rural youth.
CI  - Copyright (c) 2020 Cardiological Society of India. Published by Elsevier B.V. All 
      rights reserved.
FAU - Patil, Rahul S
AU  - Patil RS
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bengaluru, India. Electronic address: dr.rahulspatil85@gmail.com.
FAU - Shetty, Laxmi H
AU  - Shetty LH
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bengaluru, India. Electronic address: drlaxmihsn@gmail.com.
FAU - Krishnan, Shanmugam
AU  - Krishnan S
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bengaluru, India. Electronic address: shanmugammmc@gmail.com.
FAU - Trivedi, Anindya Sundar
AU  - Trivedi AS
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bengaluru, India. Electronic address: anindyaagmc@gmail.com.
FAU - Raghu, T R
AU  - Raghu TR
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bengaluru, India. Electronic address: drtrraghu@gmail.com.
FAU - Manjunath, C N
AU  - Manjunath CN
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, Bengaluru, India. Electronic address: drcnmanjunath@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20200812
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
SB  - IM
MH  - Adult
MH  - Coronary Angiography
MH  - Coronary Artery Disease/diagnosis/*epidemiology
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Prevalence
MH  - Prospective Studies
MH  - *Registries
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - *Rural Population
MH  - Young Adult
PMC - PMC7670274
OTO - NOTNLM
OT  - Abdominal obesity
OT  - Low HDL
OT  - Premature coronary artery disease
OT  - Prospective observational study
OT  - Rural youth
OT  - Smoking
OT  - Under 35years
COIS- Declaration of competing interest All authors have none to declare.
EDAT- 2020/11/16 06:00
MHDA- 2021/05/12 06:00
PMCR- 2020/09/01
CRDT- 2020/11/15 20:18
PHST- 2020/05/07 00:00 [received]
PHST- 2020/07/19 00:00 [revised]
PHST- 2020/08/03 00:00 [accepted]
PHST- 2020/11/15 20:18 [entrez]
PHST- 2020/11/16 06:00 [pubmed]
PHST- 2021/05/12 06:00 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - S0019-4832(20)30186-3 [pii]
AID - 10.1016/j.ihj.2020.08.002 [doi]
PST - ppublish
SO  - Indian Heart J. 2020 Sep-Oct;72(5):394-397. doi: 10.1016/j.ihj.2020.08.002. Epub 
      2020 Aug 12.