PMID- 33189423
OWN - NLM
STAT- MEDLINE
DCOM- 20211004
LR  - 20211004
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 82
IP  - 1
DP  - 2021 Jan
TI  - HLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population.
PG  - 11-18
LID - S0198-8859(20)30415-8 [pii]
LID - 10.1016/j.humimm.2020.10.008 [doi]
AB  - Despite intense efforts, the number of new cases of leprosy has remained 
      significantly high over the past 20 years. Host genetic background is strongly 
      linked to the pathogenesis of this disease, which is caused by Mycobacterium 
      leprae (M. leprae), and there is a consensus that the most significant genetic 
      association with leprosy is attributed to the major histocompatibility complex 
      (MHC). Here, we investigated the association of human leukocyte antigen (HLA) 
      class I and II genes with leprosy in a Brazilian population encompassing 826 
      individuals from a hyperendemic area of Brazil; HLA typing of class I (-A, -B, 
      -C) and class II (-DRB1, -DQA1, -DQB1, -DPA1, and -DPB1) loci was conducted. 
      Initially, the associations were tested using the chi-square test, with p-values 
      adjusted using the false discovery rate (FDR) method. Next, statistically 
      significant signals of the associations were submitted to logistic regression 
      analyses to adjust for sex and molecular ancestry data. The results showed that 
      HLA-C*08, -DPB1*04, and -DPB1*18 were associated with protective effects, while 
      HLA-C*12 and -DPB1*105 were associated with susceptibility to leprosy. Thus, our 
      findings reveal new associations between leprosy and the HLA-DPB1 locus and 
      confirm previous associations between the HLA-C locus and leprosy.
CI  - Copyright (c) 2020 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Covolo de Souza-Santana, Fabiana
AU  - Covolo de Souza-Santana F
AD  - Lauro de Souza Lima Institute, Bauru 17034-971, Brazil.
FAU - Querino, Gislaine Aparecida
AU  - Querino GA
AD  - Lauro de Souza Lima Institute, Bauru 17034-971, Brazil; Sao Paulo State 
      University (UNESP), Medical School, Botucatu 18618-687, Brazil.
FAU - Mendes Camargo, Rodrigo
AU  - Mendes Camargo R
AD  - Lauro de Souza Lima Institute, Bauru 17034-971, Brazil; Sao Paulo State 
      University (UNESP), Medical School, Botucatu 18618-687, Brazil.
FAU - Nieto Brito de Souza, Vania
AU  - Nieto Brito de Souza V
AD  - Lauro de Souza Lima Institute, Bauru 17034-971, Brazil; Sao Paulo State 
      University (UNESP), Medical School, Botucatu 18618-687, Brazil.
FAU - Bettoni Ballallai Mangilli, Priscila
AU  - Bettoni Ballallai Mangilli P
AD  - Lauro de Souza Lima Institute, Bauru 17034-971, Brazil.
FAU - Tavora Mira, Marcelo
AU  - Tavora Mira M
AD  - Graduate Program in Health Sciences, School of Medicine, Pontificia Universidade 
      Catolica do Parana, Curitiba 80215-901, Brazil.
FAU - Cavalcanti Bezerra, Ohanna
AU  - Cavalcanti Bezerra O
AD  - Leprosy Laboratory, Oswaldo Cruz Institute-Fiocruz, Rio de Janeiro 21040-360, 
      Brazil.
FAU - Kehdy, Fernanda
AU  - Kehdy F
AD  - Leprosy Laboratory, Oswaldo Cruz Institute-Fiocruz, Rio de Janeiro 21040-360, 
      Brazil.
FAU - Laguila Visentainer, Jeane Eliete
AU  - Laguila Visentainer JE
AD  - Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State 
      University (UEM), Maringa 87020-900, Brazil.
FAU - Alves, Hugo Vicentin
AU  - Alves HV
AD  - Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State 
      University (UEM), Maringa 87020-900, Brazil.
FAU - Jarduli, Luciana Ribeiro
AU  - Jarduli LR
AD  - Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State 
      University (UEM), Maringa 87020-900, Brazil.
FAU - Ozorio Moraes, Milton
AU  - Ozorio Moraes M
AD  - Leprosy Laboratory, Oswaldo Cruz Institute-Fiocruz, Rio de Janeiro 21040-360, 
      Brazil.
FAU - Valin Camarinha Marcos, Elaine
AU  - Valin Camarinha Marcos E
AD  - Lauro de Souza Lima Institute, Bauru 17034-971, Brazil.
FAU - Pereira Latini, Ana Carla
AU  - Pereira Latini AC
AD  - Lauro de Souza Lima Institute, Bauru 17034-971, Brazil; Sao Paulo State 
      University (UNESP), Medical School, Botucatu 18618-687, Brazil. Electronic 
      address: anacarlap@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20201111
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Brazil/epidemiology
MH  - Case-Control Studies
MH  - Endemic Diseases
MH  - Female
MH  - Genetic Loci
MH  - *Genetic Predisposition to Disease
MH  - HLA-C Antigens/*genetics/immunology
MH  - HLA-DP beta-Chains/*genetics/immunology
MH  - Humans
MH  - Leprosy/epidemiology/*genetics/immunology/microbiology
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium leprae/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - Genetic susceptibility
OT  - HLA
OT  - Leprosy
OT  - Mycobacterium leprae
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/11/16 06:00
MHDA- 2021/10/05 06:00
CRDT- 2020/11/15 20:22
PHST- 2020/08/07 00:00 [received]
PHST- 2020/10/21 00:00 [revised]
PHST- 2020/10/21 00:00 [accepted]
PHST- 2020/11/16 06:00 [pubmed]
PHST- 2021/10/05 06:00 [medline]
PHST- 2020/11/15 20:22 [entrez]
AID - S0198-8859(20)30415-8 [pii]
AID - 10.1016/j.humimm.2020.10.008 [doi]
PST - ppublish
SO  - Hum Immunol. 2021 Jan;82(1):11-18. doi: 10.1016/j.humimm.2020.10.008. Epub 2020 
      Nov 11.