PMID- 33189590
OWN - NLM
STAT- MEDLINE
DCOM- 20211217
LR  - 20211217
IS  - 1878-3562 (Electronic)
IS  - 1590-8658 (Linking)
VI  - 53
IP  - 1
DP  - 2021 Jan
TI  - IBDs and the pediatric age: Their peculiarities and the involvement of the 
      microbiota.
PG  - 17-25
LID - S1590-8658(20)30988-9 [pii]
LID - 10.1016/j.dld.2020.10.033 [doi]
AB  - Inflammatory Bowel Diseases (IBDs) are gastrointestinal disorders characterized 
      by chronic, relapsing inflammation, with growing incidence worldwide over the 
      last decades and distinctive features in the pediatric age. An increasing body of 
      evidence indicates that gut microbiota plays a major role in inflammatory 
      disorders, including IBDs. In this review we will discuss the most recent 
      evidences on dysbiotic changes associated with gut inflammation, as well as 
      environmental and genetic factors contributing to IBD pathogenesis, with a focus 
      on the peculiarities of the pediatric age.
CI  - Copyright (c) 2020 Editrice Gastroenterologica Italiana S.r.l. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Cococcioni, Lucia
AU  - Cococcioni L
AD  - Department of Pediatrics, Vittore Buzzi Children's Hospital, Universita di 
      Milano, Italy.
FAU - Panelli, Simona
AU  - Panelli S
AD  - "L. Sacco" Department of Biomedical and Clinical Sciences and Pediatric Clinical 
      Research Center "Romeo ed Enrica Invernizzi", Universita di Milano, Italy. 
      Electronic address: simona.panelli1@unimi.it.
FAU - Varotto-Boccazzi, Ilaria
AU  - Varotto-Boccazzi I
AD  - Department of Biosciences, Universita di Milano, Italy.
FAU - Carlo, Domenico Di
AU  - Carlo DD
AD  - Department of Biosciences and Pediatric Clinical Research Center "Romeo ed Enrica 
      Invernizzi", Universita di Milano, Italy.
FAU - Pistone, Dario
AU  - Pistone D
AD  - Department of Biomedical Sciences for Health, University di Milano, Italy.
FAU - Leccese, Gabriella
AU  - Leccese G
AD  - Department of Biosciences, Universita di Milano, Italy.
FAU - Zuccotti, Gian Vincenzo
AU  - Zuccotti GV
AD  - Department of Pediatrics, Vittore Buzzi Children's Hospital, Universita di 
      Milano, Italy; "L. Sacco" Department of Biomedical and Clinical Sciences and 
      Pediatric Clinical Research Center "Romeo ed Enrica Invernizzi", Universita di 
      Milano, Italy.
FAU - Comandatore, Francesco
AU  - Comandatore F
AD  - "L. Sacco" Department of Biomedical and Clinical Sciences and Pediatric Clinical 
      Research Center "Romeo ed Enrica Invernizzi", Universita di Milano, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201111
PL  - Netherlands
TA  - Dig Liver Dis
JT  - Digestive and liver disease : official journal of the Italian Society of 
      Gastroenterology and the Italian Association for the Study of the Liver
JID - 100958385
RN  - Pediatric Crohn's disease
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Colitis, Ulcerative/immunology/*microbiology
MH  - Crohn Disease/immunology/*microbiology
MH  - Dysbiosis
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
OTO - NOTNLM
OT  - Crohn's disease
OT  - IBD
OT  - Microbiota
OT  - Pediatrics
OT  - Ulcerative colitis
COIS- Declaration of Competing Interest The authors declare no conflict of interests
EDAT- 2020/11/16 06:00
MHDA- 2021/12/18 06:00
CRDT- 2020/11/15 20:23
PHST- 2020/07/24 00:00 [received]
PHST- 2020/10/26 00:00 [revised]
PHST- 2020/10/26 00:00 [accepted]
PHST- 2020/11/16 06:00 [pubmed]
PHST- 2021/12/18 06:00 [medline]
PHST- 2020/11/15 20:23 [entrez]
AID - S1590-8658(20)30988-9 [pii]
AID - 10.1016/j.dld.2020.10.033 [doi]
PST - ppublish
SO  - Dig Liver Dis. 2021 Jan;53(1):17-25. doi: 10.1016/j.dld.2020.10.033. Epub 2020 
      Nov 11.