PMID- 33189640
OWN - NLM
STAT- MEDLINE
DCOM- 20210809
LR  - 20210817
IS  - 1876-7605 (Electronic)
IS  - 1936-8798 (Linking)
VI  - 13
IP  - 23
DP  - 2020 Dec 14
TI  - Functional and Echocardiographic Improvement After Transcatheter Repair for 
      Tricuspid Regurgitation: A Systematic Review and Pooled Analysis.
PG  - 2719-2729
LID - S1936-8798(20)31714-3 [pii]
LID - 10.1016/j.jcin.2020.08.020 [doi]
AB  - OBJECTIVES: The aim of this study was to assess the feasibility, efficacy, and 
      clinical outcomes of transcatheter repair of tricuspid regurgitation (TR) in a 
      pooled analysis of interventional studies. BACKGROUND: New percutaneous devices 
      are available to treat severe TR, but the evidence is sparse and limited to 
      smaller cohorts. METHODS: Several electronic databases were searched for 
      interventional studies involving percutaneous repair of TR. Devices used were the 
      Cardioband, FORMA, MitraClip, PASCAL, and Trialign. Outcomes included in the 
      final analysis were successful implantation, residual severe TR, post-procedural 
      New York Heart Association (NYHA) functional class III or IV, 6-min walk 
      distance, and echocardiographic parameters. Subgroup and meta-regression analysis 
      were performed to further explore residual heterogeneity. RESULTS: Seven studies 
      and 454 patients undergoing transcatheter tricuspid valve repair were included in 
      the pooled analysis; 95% of patients had at least severe TR, and 91% were in NYHA 
      functional class III or IV. Successful implantation was achieved in 86% of 
      patients. At the longest follow-up available (weighted mean 265 days), 9% had 
      died. Compared with baseline, a significantly lower proportion of patients had at 
      least severe TR (relative risk: 0.38; 95% confidence interval: 0.20 to 0.70; 
      p = 0.004) and were in NYHA functional class III or IV (relative risk: 0.23; 95% 
      confidence interval: 0.20 to 0.30; p < 0.001). Patients also experienced 
      increases in 6-min walk distance (mean difference +64.6 m; p < 0.001) and 
      significant reductions in tricuspid valve annular diameter (mean 
      difference -3 mm; p < 0.001), while left and right ventricular function did not 
      change significantly. CONCLUSIONS: A strategy of transcatheter repair for severe 
      TR appears to be feasible, effective, and associated with improved clinical 
      outcomes at mid-term follow-up.
CI  - Copyright (c) 2020 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Montalto, Claudio
AU  - Montalto C
AD  - Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 
      Electronic address: https://twitter.com/MdMontalto.
FAU - Sticchi, Alessandro
AU  - Sticchi A
AD  - Campus Bio-Medico di Roma, Rome, Italy; GVM Care and Research, Maria Cecilia 
      Hospital, Cotignola, Italy.
FAU - Crimi, Gabriele
AU  - Crimi G
AD  - Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 
      Campus Bio-Medico di Roma, Rome, Italy; GVM Care and Research, Maria Cecilia 
      Hospital, Cotignola, Italy; Interventional Cardiology Unit, Thoraco Vascular 
      Department (DICATOV), IRCCS Policlinico San Martino, Genova, Italy.
FAU - Laricchia, Alessandra
AU  - Laricchia A
AD  - GVM Care and Research, Maria Cecilia Hospital, Cotignola, Italy.
FAU - Khokhar, Arif
AU  - Khokhar A
AD  - GVM Care and Research, Maria Cecilia Hospital, Cotignola, Italy.
FAU - Giannini, Francesco
AU  - Giannini F
AD  - GVM Care and Research, Maria Cecilia Hospital, Cotignola, Italy.
FAU - Ferlini, Marco
AU  - Ferlini M
AD  - Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Colombo, Antonio
AU  - Colombo A
AD  - GVM Care and Research, Maria Cecilia Hospital, Cotignola, Italy.
FAU - Latib, Azeem
AU  - Latib A
AD  - Montefiore Medical Center, New York, New York, USA. Electronic address: 
      https://twitter.com/azeemlatib.
FAU - Mangieri, Antonio
AU  - Mangieri A
AD  - GVM Care and Research, Maria Cecilia Hospital, Cotignola, Italy. Electronic 
      address: antonio.mangieri@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20201111
PL  - United States
TA  - JACC Cardiovasc Interv
JT  - JACC. Cardiovascular interventions
JID - 101467004
SB  - IM
CIN - JACC Cardiovasc Interv. 2020 Dec 14;13(23):2730-2731. PMID: 33189648
CIN - JACC Cardiovasc Interv. 2021 Mar 8;14(5):584-585. PMID: 33663789
CIN - JACC Cardiovasc Interv. 2021 Mar 8;14(5):585-586. PMID: 33663790
MH  - Cardiac Catheterization
MH  - Echocardiography
MH  - *Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Tricuspid Valve Insufficiency/surgery
OTO - NOTNLM
OT  - heart failure
OT  - transcatheter tricuspid valve repair
OT  - tricuspid regurgitation
OT  - tricuspid valve
COIS- Author Disclosures The authors have reported that they have no relationships 
      relevant to the contents of this paper to disclose.
EDAT- 2020/11/16 06:00
MHDA- 2021/08/10 06:00
CRDT- 2020/11/15 20:24
PHST- 2020/04/17 00:00 [received]
PHST- 2020/07/20 00:00 [revised]
PHST- 2020/08/11 00:00 [accepted]
PHST- 2020/11/16 06:00 [pubmed]
PHST- 2021/08/10 06:00 [medline]
PHST- 2020/11/15 20:24 [entrez]
AID - S1936-8798(20)31714-3 [pii]
AID - 10.1016/j.jcin.2020.08.020 [doi]
PST - ppublish
SO  - JACC Cardiovasc Interv. 2020 Dec 14;13(23):2719-2729. doi: 
      10.1016/j.jcin.2020.08.020. Epub 2020 Nov 11.