PMID- 33189863
OWN - NLM
STAT- MEDLINE
DCOM- 20210812
LR  - 20240226
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 520
DP  - 2021 Jan 15
TI  - Polydatin enhances glomerular podocyte autophagy homeostasis by improving 
      Nrf2-dependent antioxidant capacity in fructose-fed rats.
PG  - 111079
LID - S0303-7207(20)30381-6 [pii]
LID - 10.1016/j.mce.2020.111079 [doi]
AB  - High fructose is considered a causative factor for oxidative stress and autophagy 
      imbalance that cause kidney pathogenesis. Antioxidant polydatin isolated from 
      Polygonum cuspidatum has been reported to protect against kidney injury. In this 
      study, polydatin was found to ameliorate fructose-induced podocyte injury. It 
      activated mammalian target of rapamycin complex 1 (mTORC1) and suppressed 
      autophagy in glomeruli of fructose-fed rats and in fructose-exposed conditionally 
      immortalized human podocytes (HPCs). Polydatin also enhanced nuclear 
      factor-E2-related factor 2 (Nrf2)-dependent antioxidant capacity to suppress 
      fructose-induced autophagy activation in vivo and in vitro, with the attenuation 
      of fructose-induced up-regulation of cellular light chain 3 (LC3) II/I protein 
      levels. This effect was abolished by Raptor siRNA in fructose-exposed HPCs. These 
      results demonstrated that polydatin ameliorated fructose-induced autophagy 
      imbalance in an mTORC1-dependent manner via improving Nrf2-dependent antioxidant 
      capacity during podocyte injury. In conclusion, polydatin with anti-oxidation 
      activity suppressed autophagy to protect against fructose-induced podocyte 
      injury.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Gu, Ting-Ting
AU  - Gu TT
AD  - State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, 
      Nanjing University, Nanjing, PR China.
FAU - Zhang, Dong-Mei
AU  - Zhang DM
AD  - State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, 
      Nanjing University, Nanjing, PR China.
FAU - Wan, Zi-Yan
AU  - Wan ZY
AD  - State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, 
      Nanjing University, Nanjing, PR China.
FAU - Li, Tu-Shuai
AU  - Li TS
AD  - State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, 
      Nanjing University, Nanjing, PR China.
FAU - Jiao, Rui-Qing
AU  - Jiao RQ
AD  - State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, 
      Nanjing University, Nanjing, PR China.
FAU - Chen, Tian-Yu
AU  - Chen TY
AD  - State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, 
      Nanjing University, Nanjing, PR China.
FAU - Zhao, Xiao-Juan
AU  - Zhao XJ
AD  - State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, 
      Nanjing University, Nanjing, PR China.
FAU - Kong, Ling-Dong
AU  - Kong LD
AD  - State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, 
      Nanjing University, Nanjing, PR China. Electronic address: kongld@nju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201112
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Antioxidants)
RN  - 0 (Glucosides)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Stilbenes)
RN  - 30237-26-4 (Fructose)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 2.7.4.3 (Adenylate Kinase)
RN  - XM261C37CQ (polydatin)
SB  - IM
EIN - Mol Cell Endocrinol. 2023 Mar 15;564:111876. PMID: 36753997
MH  - Adenosine Triphosphate/biosynthesis
MH  - Adenylate Kinase/metabolism
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - *Autophagy/drug effects
MH  - *Feeding Behavior
MH  - Fructose
MH  - Glucosides/*pharmacology
MH  - *Homeostasis/drug effects
MH  - Humans
MH  - Male
MH  - Mechanistic Target of Rapamycin Complex 1/metabolism
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Oxidative Stress/drug effects
MH  - Podocytes/drug effects/*metabolism/pathology
MH  - Proteinuria/complications
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects
MH  - Stilbenes/*pharmacology
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
MH  - Rats
OTO - NOTNLM
OT  - Autophagy
OT  - Fructose
OT  - Oxidative stress
OT  - Podocyte injury
OT  - Polydatin
EDAT- 2020/11/16 06:00
MHDA- 2021/08/13 06:00
CRDT- 2020/11/15 20:25
PHST- 2020/04/28 00:00 [received]
PHST- 2020/11/05 00:00 [revised]
PHST- 2020/11/07 00:00 [accepted]
PHST- 2020/11/16 06:00 [pubmed]
PHST- 2021/08/13 06:00 [medline]
PHST- 2020/11/15 20:25 [entrez]
AID - S0303-7207(20)30381-6 [pii]
AID - 10.1016/j.mce.2020.111079 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2021 Jan 15;520:111079. doi: 10.1016/j.mce.2020.111079. Epub 
      2020 Nov 12.