PMID- 3319040
OWN - NLM
STAT- MEDLINE
DCOM- 19880210
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 421
IP  - 1-2
DP  - 1987 Sep 22
TI  - Some transforming growth factor-alpha connections and their colocalization with 
      enkephalin in the rat central nervous system.
PG  - 401-5
AB  - Transforming growth factor alpha (TGF alpha) has been immunocytochemically 
      localized in neuronal perikarya throughout the adult rat central nervous system 
      (CNS). In order to determine if any TGF alpha-immunoreactive (TGF alpha-I) cell 
      bodies have long axonal projections, indirect immunofluorescence was used in 
      combination with injections of the fluorescent retrograde tracer, Fluoro-Gold 
      (FG). Both TGF alpha-I and retrogradely transported FG were found within the same 
      neurons in the interpeduncular nucleus (IPN) after bilateral FG injections in the 
      dorsal tegmental nucleus (DTg). Neurons that contain both TGF alpha-I and FG were 
      also found in the raphe magnus, raphe obscurus, raphe pallidus and the 
      gigantocellularis reticular nuclei after FG injections in the upper thoracic 
      spinal cord. Cell bodies double-labeled with TGF alpha-I and FG were found in the 
      dorsal parabrachial nucleus (DPB) following FG injections in the central nucleus 
      of the amygdala (Ce). In addition, Leu-enkephalin immunoreactivity (L-ENK-I) was 
      colocalized with TGF alpha-I in the same projection neurons after the injections 
      described above. These results suggest that cells that contain TGF and the opioid 
      peptide, L-ENK, have long projections in the rat CNS, and that, due to their 
      co-localization within the same neurons, they may exert their effects 
      concomitantly.
FAU - Code, R A
AU  - Code RA
AD  - Department of Anatomy and Neurobiology, University of California, Irvine 92717.
FAU - Seroogy, K B
AU  - Seroogy KB
FAU - Fallon, J H
AU  - Fallon JH
LA  - eng
GR  - 1 F32 DA05290-01/DA/NIDA NIH HHS/United States
GR  - MH09090/MH/NIMH NIH HHS/United States
GR  - NS 15321/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Peptides)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 76057-06-2 (Transforming Growth Factors)
SB  - IM
MH  - Animals
MH  - Brain/*cytology/metabolism
MH  - Enkephalin, Leucine/*analysis
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Immunohistochemistry
MH  - Male
MH  - Neurons/analysis/classification
MH  - Peptides/*analysis
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Spinal Cord/analysis/*cytology
MH  - Transforming Growth Factors
EDAT- 1987/09/22 00:00
MHDA- 1987/09/22 00:01
CRDT- 1987/09/22 00:00
PHST- 1987/09/22 00:00 [pubmed]
PHST- 1987/09/22 00:01 [medline]
PHST- 1987/09/22 00:00 [entrez]
AID - 0006-8993(87)91317-5 [pii]
AID - 10.1016/0006-8993(87)91317-5 [doi]
PST - ppublish
SO  - Brain Res. 1987 Sep 22;421(1-2):401-5. doi: 10.1016/0006-8993(87)91317-5.