PMID- 33190967
OWN - NLM
STAT- MEDLINE
DCOM- 20210831
LR  - 20210831
IS  - 2174-2049 (Electronic)
IS  - 2174-2049 (Linking)
VI  - 39
IP  - 12
DP  - 2020 Dec
TI  - D-dimers are associated with coronary artery disease severity assessed using 
      Syntax and Syntax II scores in patients with ST elevation myocardial infarction.
PG  - 687-693
LID - S0870-2551(20)30421-2 [pii]
LID - 10.1016/j.repc.2020.08.006 [doi]
AB  - INTRODUCTION AND OBJECTIVES: D-dimers are a determinant of hypercoagulable state 
      and have been found to be related to acute coronary syndromes. We aimed to 
      establish the association between increased D-dimer levels and coronary artery 
      disease (CAD) severity using SYNTAX Score (SS) II in patients with ST elevation 
      myocardial infarction (STEMI) who underwent primary percutaneous coronary 
      intervention (PCI). METHODS: This retrospective study included 300 consecutive 
      patients (81.7% males, mean age 55+/-12 years) with STEMI who underwent a primary 
      PCI. Patients were divided into two groups according to their median SSII 
      [SSII<25 as a low group (n=151) and SSII>/=25 as a high group (n=149)]. Blood 
      samples for D-dimers and the other biochemical parameters were obtained from each 
      patient at admission. RESULTS: When compared with the low SSII group, frequency 
      of female gender, no-reflow phenomenon, D-dimer levels, thrombus score, creatine 
      kinase MB and troponin were significantly higher, whereas left ventricular 
      ejection fraction (LVEF) and glomerular filtration rate (GFR) were lower in the 
      high SSII group (p<0.05, for all). D-dimer levels, thrombus score, LVEF, GFR and 
      no-reflow phenomenon were independent predictors of CAD severity (p<0.05, for 
      all). Receiver operating characteristic curve analysis showed that the D-dimer 
      cut-off value for predicting the severity of CAD was 0.26 mug/ml (69.8% 
      sensitivity and 65.6% specificity, p<0.001). CONCLUSION: Increased D-dimer levels 
      are associated with the severity of CAD based on Syntax Score II, in patients 
      with STEMI who successfully underwent revascularization with a primary PCI.
CI  - Copyright (c) 2020 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier 
      Espana, S.L.U. All rights reserved.
FAU - Turkoglu, Caner
AU  - Turkoglu C
AD  - Malatya Training and Research Hospital, Department of Cardiology, Malatya, 
      Turkey. Electronic address: canerturkoglu83@hotmail.com.
FAU - Harbalioglu, Hazar
AU  - Harbalioglu H
AD  - Duzce Ataturk State Hospital, Department of Cardiology, Duzce, Turkey.
FAU - Seker, Taner
AU  - Seker T
AD  - Adana City Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey.
FAU - Baykan, Ahmet Oytun
AU  - Baykan AO
AD  - Adana Ortadogu Hospital, Department of Cardiology, Adana, Turkey.
FAU - Uysal, Onur Kadir
AU  - Uysal OK
AD  - Adana City Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey.
LA  - eng
LA  - por
PT  - Journal Article
DEP - 20201113
PL  - Spain
TA  - Rev Port Cardiol (Engl Ed)
JT  - Revista portuguesa de cardiologia
JID - 101770878
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (fibrin fragment D)
SB  - IM
CIN - Rev Port Cardiol (Engl Ed). 2020 Dec;39(12):695-696. PMID: 33309129
MH  - Adult
MH  - Aged
MH  - *Coronary Artery Disease
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Percutaneous Coronary Intervention
MH  - Retrospective Studies
MH  - *ST Elevation Myocardial Infarction/surgery
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - D-dimers
OT  - D-dimeros
OT  - Enfarte do miocardio
OT  - Myocardial infarction
OT  - SYNTAX score II
OT  - Score SYNTAX II
EDAT- 2020/11/17 06:00
MHDA- 2021/09/01 06:00
CRDT- 2020/11/16 05:30
PHST- 2019/11/09 00:00 [received]
PHST- 2020/07/09 00:00 [revised]
PHST- 2020/08/24 00:00 [accepted]
PHST- 2020/11/17 06:00 [pubmed]
PHST- 2021/09/01 06:00 [medline]
PHST- 2020/11/16 05:30 [entrez]
AID - S0870-2551(20)30421-2 [pii]
AID - 10.1016/j.repc.2020.08.006 [doi]
PST - ppublish
SO  - Rev Port Cardiol (Engl Ed). 2020 Dec;39(12):687-693. doi: 
      10.1016/j.repc.2020.08.006. Epub 2020 Nov 13.