PMID- 33191834
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20220531
IS  - 1473-0790 (Electronic)
IS  - 1368-5538 (Linking)
VI  - 23
IP  - 5
DP  - 2020 Dec
TI  - Levels of TNF-alpha, IL-6, IL-17, IL-37 cytokines in patients with active vitiligo.
PG  - 1487-1492
LID - 10.1080/13685538.2020.1806814 [doi]
AB  - OBJECTIVES: Vitiligo is an autoimmune disease, and its pathogenesis involves 
      changes in cytokine levels in the affected patients. Tumor necrosis factor-alpha 
      (TNF-alpha), interleukin (IL)-6, and IL-17 from pro-inflammatory cytokines, IL-37 in 
      a recently detected anti-inflammatory activity. The aim of our study was to 
      determine serum TNF-alpha, IL-6, IL-17, IL-37 levels in patients with vitiligo to 
      understand their possible roles in the disease etiology and to compare the 
      results with the healthy controls. METHODS: The study included 48 generalized 
      vitiligo patients who were diagnosed with vitiligo, had an increase in the 
      lesions within the last 3 months, and did not receive any systemic or topical 
      treatment during this period; furthermore, 18 healthy controls were included. 
      RESULTS: Patient group: n = 48, mean age = 30.48 +/- 9.86 years; control group: 
      n = 18, mean age = 28.27 +/- 9.66 years. Individuals in the patient group had 
      significantly higher serum levels of IL-37(t = 3.90, p < .001), IL-6 (t = 3.39, p 
      < .05), IL-17 (t = 2.08, p < .05), and TNF-alpha (t = 4.69 p < .001) than in the 
      control group. CONCLUSION: The high levels of (pro-anti) inflammatory cytokines 
      in vitiligo patients draw attention to the importance of cytokines in the 
      pathogenesis of the disease.
FAU - Karagun, Ebru
AU  - Karagun E
AD  - Department of Dermatology, Duzce University Medical School, Duzce, Turkey.
FAU - Baysak, Sevim
AU  - Baysak S
AD  - Department of Dermatology, Istanbul Sultan Abdulhamid Han Training and Research 
      Hospital, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20201116
PL  - England
TA  - Aging Male
JT  - The aging male : the official journal of the International Society for the Study 
      of the Aging Male
JID - 9808210
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cytokines
MH  - Humans
MH  - Interleukin-17
MH  - Interleukin-6
MH  - *Tumor Necrosis Factor-alpha
MH  - *Vitiligo
MH  - Young Adult
OTO - NOTNLM
OT  - IL-17
OT  - IL-37
OT  - IL-6
OT  - TNF-alpha
OT  - pathogenesis
OT  - vitiligo
EDAT- 2020/11/17 06:00
MHDA- 2021/10/26 06:00
CRDT- 2020/11/16 08:41
PHST- 2020/11/17 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2020/11/16 08:41 [entrez]
AID - 10.1080/13685538.2020.1806814 [doi]
PST - ppublish
SO  - Aging Male. 2020 Dec;23(5):1487-1492. doi: 10.1080/13685538.2020.1806814. Epub 
      2020 Nov 16.