PMID- 33191992 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231111 IS - 0970-9134 (Print) IS - 0973-7723 (Electronic) IS - 0970-9134 (Linking) VI - 37 IP - Suppl 2 DP - 2021 Apr TI - Veno-arterial extracorporeal membrane oxygenation: Special reference for use in 'post-cardiotomy cardiogenic shock' - A review with an Indian perspective. PG - 275-288 LID - 10.1007/s12055-020-01051-7 [doi] AB - The ultimate goals of cardiovascular physiology are to ensure adequate end-organ perfusion to satisfy the local metabolic demand, to maintain homeostasis and achieve 'milieu interieur'. Cardiogenic shock is a state of pump failure which results in tissue hypoperfusion and its associated complications. There are a wide variety of causes which lead to this deranged physiology, and one such important and common scenario is the post-cardiotomy state which is encountered in cardiac surgical units. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an important modality of managing post-cardiotomy cardiogenic shock with variable outcomes which would otherwise be universally fatal. VA-ECMO is considered as a double-edged sword with the advantages of luxurious perfusion while providing an avenue for the failing heart to recover, but with the problems of anticoagulation, inflammatory and adverse systemic effects. Optimal outcomes after VA-ECMO are heavily reliant on a multitude of factors and require a multi-disciplinary team to handle them. This article aims to provide an insight into the pathophysiology of VA-ECMO, cannulation techniques, commonly encountered problems, monitoring, weaning strategies and ethical considerations along with a literature review of current evidence-based practices. CI - (c) Indian Association of Cardiovascular-Thoracic Surgeons 2020. FAU - Patangi, Sanjay Orathi AU - Patangi SO AUID- ORCID: 0000-0002-5303-2925 AD - Department of Anaesthesia and Intensive Care, Narayana Institute of Cardiac Sciences, 258/A Hosur Road, Bommasandra Industrial Area, Anekal Taluk, Bengaluru, Karnataka 560099 India. GRID: grid.416504.2. ISNI: 0000 0004 1796 819X FAU - Shetty, Riyan Sukumar AU - Shetty RS AD - Department of Anaesthesia and Intensive Care, Narayana Institute of Cardiac Sciences, 258/A Hosur Road, Bommasandra Industrial Area, Anekal Taluk, Bengaluru, Karnataka 560099 India. GRID: grid.416504.2. ISNI: 0000 0004 1796 819X FAU - Shanmugasundaram, Balasubramanian AU - Shanmugasundaram B AD - Department of Anaesthesia and Intensive Care, Narayana Institute of Cardiac Sciences, 258/A Hosur Road, Bommasandra Industrial Area, Anekal Taluk, Bengaluru, Karnataka 560099 India. GRID: grid.416504.2. ISNI: 0000 0004 1796 819X FAU - Kasturi, Srikanth AU - Kasturi S AD - Department of Cardiothoracic Surgery, Narayana Institute of Cardiac Sciences, Bengaluru, India. GRID: grid.416504.2. ISNI: 0000 0004 1796 819X FAU - Raheja, Shivangi AU - Raheja S AD - Department of Cardiothoracic Surgery, Narayana Institute of Cardiac Sciences, Bengaluru, India. GRID: grid.416504.2. ISNI: 0000 0004 1796 819X LA - eng PT - Journal Article DEP - 20201107 PL - India TA - Indian J Thorac Cardiovasc Surg JT - Indian journal of thoracic and cardiovascular surgery JID - 8700105 PMC - PMC7647874 OTO - NOTNLM OT - Extracorporeal membrane oxygenation OT - Post-cardiotomy cardiogenic shock COIS- Conflict of interestThe authors declare that they have no competing interests. EDAT- 2020/11/17 06:00 MHDA- 2020/11/17 06:01 PMCR- 2022/04/01 CRDT- 2020/11/16 08:42 PHST- 2020/06/23 00:00 [received] PHST- 2020/08/14 00:00 [revised] PHST- 2020/09/07 00:00 [accepted] PHST- 2020/11/17 06:00 [pubmed] PHST- 2020/11/17 06:01 [medline] PHST- 2020/11/16 08:42 [entrez] PHST- 2022/04/01 00:00 [pmc-release] AID - 1051 [pii] AID - 10.1007/s12055-020-01051-7 [doi] PST - ppublish SO - Indian J Thorac Cardiovasc Surg. 2021 Apr;37(Suppl 2):275-288. doi: 10.1007/s12055-020-01051-7. Epub 2020 Nov 7.