PMID- 33192363
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201117
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 14
DP  - 2020
TI  - Involvement of the Postrhinal and Perirhinal Cortices in Microscale and 
      Macroscale Visuospatial Information Encoding.
PG  - 556645
LID - 10.3389/fnbeh.2020.556645 [doi]
LID - 556645
AB  - Whereas the postrhinal cortex (POR) is a critical center for the integration of 
      egocentric and allocentric spatial information, the perirhinal cortex (PRC) plays 
      an important role in the encoding of objects that supports spatial learning. The 
      POR and PRC send afferents to the hippocampus, a structure that builds complex 
      associative memories from the spatial experience. Hippocampal encoding of 
      item-place experience is accompanied by the nuclear expression of immediate early 
      gene (IEGs). Subfields of the Cornus ammonius and subregions of the hippocampus 
      exhibit differentiated and distinct encoding responses, depending on whether the 
      spatial location and relationships of large highly visible items (macroscale 
      encoding) or small partially concealed items (microscale encoding), is learned. 
      But to what extent the PRC and POR support hippocampal processing of different 
      kinds of item-place representations is unclear. Using fluorescence in situ 
      hybridization (FISH), we examined the effect of macroscale (overt, landmark) and 
      microscale (subtle, discrete) item-place learning on the nuclear expression of 
      the IEG, Arc. We observed an increase in Arc mRNA in the caudal part of PRC area 
      35 and the caudal part of the POR after macroscale, but not microscale item-place 
      learning. The caudal part of PRC area 36, the rostral and middle parts of PRC 
      areas 35 and 36, as well as the middle part of the POR responded to neither type 
      of item. These results suggest that macroscale items may contain a strong 
      identity component that is processed by specific compartments of the PRC and POR. 
      In contrast small, microscale items are not encoded by the POR or PRC, indicating 
      that item dimensions may play a role in the involvement of these structures in 
      item processing.
CI  - Copyright (c) 2020 Sethumadhavan, Hoang, Strauch and Manahan-Vaughan.
FAU - Sethumadhavan, Nithya
AU  - Sethumadhavan N
AD  - Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum, 
      Germany.
AD  - International Graduate School of Neuroscience, Ruhr University Bochum, Bochum, 
      Germany.
FAU - Hoang, Thu-Huong
AU  - Hoang TH
AD  - Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum, 
      Germany.
AD  - International Graduate School of Neuroscience, Ruhr University Bochum, Bochum, 
      Germany.
FAU - Strauch, Christina
AU  - Strauch C
AD  - Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum, 
      Germany.
FAU - Manahan-Vaughan, Denise
AU  - Manahan-Vaughan D
AD  - Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20201009
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC7584114
OTO - NOTNLM
OT  - fluorescence in situ hybridization
OT  - immediate early gene
OT  - perirhinal cortex
OT  - postrhinal cortex
OT  - visuospatial information processing
EDAT- 2020/11/17 06:00
MHDA- 2020/11/17 06:01
PMCR- 2020/01/01
CRDT- 2020/11/16 08:44
PHST- 2020/04/28 00:00 [received]
PHST- 2020/08/28 00:00 [accepted]
PHST- 2020/11/16 08:44 [entrez]
PHST- 2020/11/17 06:00 [pubmed]
PHST- 2020/11/17 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2020.556645 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2020 Oct 9;14:556645. doi: 10.3389/fnbeh.2020.556645. 
      eCollection 2020.