PMID- 33192473
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201117
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 12
DP  - 2020
TI  - Impaired Topographical Organization of Functional Brain Networks in Parkinson's 
      Disease Patients With Freezing of Gait.
PG  - 580564
LID - 10.3389/fnagi.2020.580564 [doi]
LID - 580564
AB  - Objective: This study aimed to explore alterations in the topological properties 
      of the functional brain network in primary Parkinson's disease (PD) patients with 
      freezing of gait (PD-FOG). Methods: Resting-state functional magnetic resonance 
      imaging (Rs-fMRI) data were obtained in 23 PD-FOG patients, 33 PD patients 
      without FOG (PD-nFOG), and 24 healthy control (HC) participants. The whole-brain 
      functional connectome was constructed by thresholding the Pearson correlation 
      matrices of 90 brain regions, and topological properties were analyzed by using 
      graph theory approaches. The network-based statistics (NBS) method was used to 
      determine the suprathreshold connected edges (P < 0.05; threshold T = 2.725), and 
      statistical significance was estimated by using the non-parametric permutation 
      method (5,000 permutations). Statistically significant topological properties 
      were further evaluated for their relationship with clinical neurological scales. 
      Results: The topological properties of the functional brain network in PD-FOG and 
      PD-nFOG showed no abnormalities at the global level. However, compared with HCs, 
      PD-FOG patients showed decreased nodal local efficiency in several brain regions, 
      including the bilateral striatum, frontoparietal areas, visual cortex, and 
      bilateral superior temporal gyrus, increased nodal local efficiency in the left 
      gyrus rectus. When compared with PD-nFOG patients and HCs, PD-FOG showed 
      increased betweenness centrality in the left hippocampus. Moreover, compared to 
      HCs, both PD-FOG and PD-nFOG patients displayed reduced network connections by 
      using the NBS method, mainly involving the sensorimotor cortex (SM), visual 
      network (VN), default mode network (DMN), auditory network (AN), dorsal attention 
      network (DAN), subcortical regions, and limbic network (LIM). The local node 
      efficiency of the right temporal pole: superior temporal gyrus in PD-FOG patients 
      was positively correlated with the Freezing of Gait Questionnaire (FOGQ) scores. 
      Conclusions: This study demonstrates the disrupted regional topological 
      organization in PD-FOG patients, especially associated with damage to the 
      subcortical regions and multiple cortical regions. Our results provide insights 
      into the dysfunctional mechanisms of the relevant networks and indicate potential 
      neuroimaging biomarkers of PD-FOG.
CI  - Copyright (c) 2020 Ruan, Li, Li, Xie, Zhang, Luo, Du, Jiang, Li, and Wei.
FAU - Ruan, Xiuhang
AU  - Ruan X
AD  - Department of Radiology, Guangzhou First People's Hospital, School of Medicine, 
      South China University of Technology, Guangzhou, China.
FAU - Li, Yuting
AU  - Li Y
AD  - Department of Radiology, Guangzhou First People's Hospital, School of Medicine, 
      South China University of Technology, Guangzhou, China.
FAU - Li, E
AU  - Li E
AD  - Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Xie, Fang
AU  - Xie F
AD  - Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Zhang, Guoqin
AU  - Zhang G
AD  - Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Luo, Zhenhang
AU  - Luo Z
AD  - GYENNO Technologies Co., Ltd., Shenzhen, China.
FAU - Du, Yuchen
AU  - Du Y
AD  - Department of Radiology, Guangzhou First People's Hospital, School of Medicine, 
      South China University of Technology, Guangzhou, China.
FAU - Jiang, Xinqing
AU  - Jiang X
AD  - Department of Radiology, Guangzhou First People's Hospital, School of Medicine, 
      South China University of Technology, Guangzhou, China.
FAU - Li, Mengyan
AU  - Li M
AD  - Department of Neurology, Guangzhou First People's Hospital, School of Medicine, 
      South China University of Technology, Guangzhou, China.
FAU - Wei, Xinhua
AU  - Wei X
AD  - Department of Radiology, Guangzhou First People's Hospital, School of Medicine, 
      South China University of Technology, Guangzhou, China.
AD  - Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20201021
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC7609969
OTO - NOTNLM
OT  - Parkinson's disease
OT  - freezing of gait
OT  - functional magnetic resonance imaging
OT  - gait disorders
OT  - graph theory
EDAT- 2020/11/17 06:00
MHDA- 2020/11/17 06:01
PMCR- 2020/01/01
CRDT- 2020/11/16 08:44
PHST- 2020/07/06 00:00 [received]
PHST- 2020/09/18 00:00 [accepted]
PHST- 2020/11/16 08:44 [entrez]
PHST- 2020/11/17 06:00 [pubmed]
PHST- 2020/11/17 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2020.580564 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2020 Oct 21;12:580564. doi: 10.3389/fnagi.2020.580564. 
      eCollection 2020.