PMID- 33193265
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201117
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 11
DP  - 2020
TI  - The Clustered Regularly Interspaced Short Palindromic Repeat System and 
      Argonaute: An Emerging Bacterial Immunity System for Defense Against Natural 
      Transformation?
PG  - 593301
LID - 10.3389/fmicb.2020.593301 [doi]
LID - 593301
AB  - Clustered regularly interspaced short palindromic repeat (CRISPR) systems and 
      prokaryotic Argonaute proteins (Agos) have been shown to defend bacterial and 
      archaeal cells against invading nucleic acids. Indeed, they are important 
      elements for inhibiting horizontal gene transfer between bacterial and archaeal 
      cells. The CRISPR system employs an RNA-guide complex to target invading DNA or 
      RNA, while Agos target DNA using single stranded DNA or RNA as guides. Thus, the 
      CRISPR and Agos systems defend against exogenous nucleic acids by different 
      mechanisms. It is not fully understood how antagonization of these systems occurs 
      during natural transformation, wherein exogenous DNA enters a host cell as single 
      stranded DNA and is then integrated into the host genome. In this review, we 
      discuss the functions and mechanisms of the CRISPR system and Agos in cellular 
      defense against natural transformation.
CI  - Copyright (c) 2020 Liu, Huang, Wang, Zhu, Jia, Chen, Zhang, Pan and Cheng.
FAU - Liu, Mafeng
AU  - Liu M
AD  - Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, 
      Chengdu, China.
AD  - Research Centre of Avian Disease, College of Veterinary Medicine of Sichuan 
      Agricultural University, Chengdu, China.
AD  - Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan 
      Agricultural University, Chengdu, China.
FAU - Huang, Mi
AU  - Huang M
AD  - Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, 
      Chengdu, China.
AD  - Research Centre of Avian Disease, College of Veterinary Medicine of Sichuan 
      Agricultural University, Chengdu, China.
AD  - Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan 
      Agricultural University, Chengdu, China.
FAU - Wang, Mingshu
AU  - Wang M
AD  - Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, 
      Chengdu, China.
AD  - Research Centre of Avian Disease, College of Veterinary Medicine of Sichuan 
      Agricultural University, Chengdu, China.
AD  - Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan 
      Agricultural University, Chengdu, China.
FAU - Zhu, Dekang
AU  - Zhu D
AD  - Research Centre of Avian Disease, College of Veterinary Medicine of Sichuan 
      Agricultural University, Chengdu, China.
AD  - Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan 
      Agricultural University, Chengdu, China.
FAU - Jia, Renyong
AU  - Jia R
AD  - Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, 
      Chengdu, China.
AD  - Research Centre of Avian Disease, College of Veterinary Medicine of Sichuan 
      Agricultural University, Chengdu, China.
AD  - Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan 
      Agricultural University, Chengdu, China.
FAU - Chen, Shun
AU  - Chen S
AD  - Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, 
      Chengdu, China.
AD  - Research Centre of Avian Disease, College of Veterinary Medicine of Sichuan 
      Agricultural University, Chengdu, China.
AD  - Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan 
      Agricultural University, Chengdu, China.
FAU - Zhang, Ling
AU  - Zhang L
AD  - Research Centre of Avian Disease, College of Veterinary Medicine of Sichuan 
      Agricultural University, Chengdu, China.
AD  - Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan 
      Agricultural University, Chengdu, China.
FAU - Pan, Leichang
AU  - Pan L
AD  - Research Centre of Avian Disease, College of Veterinary Medicine of Sichuan 
      Agricultural University, Chengdu, China.
AD  - Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan 
      Agricultural University, Chengdu, China.
FAU - Cheng, Anchun
AU  - Cheng A
AD  - Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, 
      Chengdu, China.
AD  - Research Centre of Avian Disease, College of Veterinary Medicine of Sichuan 
      Agricultural University, Chengdu, China.
AD  - Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan 
      Agricultural University, Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201022
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC7642515
OTO - NOTNLM
OT  - Argonaute proteins
OT  - Clustered regularly interspaced short palindromic repeat-Cas
OT  - bacterial immunity system
OT  - natural transformation
OT  - ssDNA
EDAT- 2020/11/17 06:00
MHDA- 2020/11/17 06:01
PMCR- 2020/10/22
CRDT- 2020/11/16 08:47
PHST- 2020/08/11 00:00 [received]
PHST- 2020/09/23 00:00 [accepted]
PHST- 2020/11/16 08:47 [entrez]
PHST- 2020/11/17 06:00 [pubmed]
PHST- 2020/11/17 06:01 [medline]
PHST- 2020/10/22 00:00 [pmc-release]
AID - 10.3389/fmicb.2020.593301 [doi]
PST - epublish
SO  - Front Microbiol. 2020 Oct 22;11:593301. doi: 10.3389/fmicb.2020.593301. 
      eCollection 2020.