PMID- 33193311
OWN - NLM
STAT- MEDLINE
DCOM- 20210428
LR  - 20240330
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 Allele and Haplotype Frequencies of 28,927 
      Saudi Stem Cell Donors Typed by Next-Generation Sequencing.
PG  - 544768
LID - 10.3389/fimmu.2020.544768 [doi]
LID - 544768
AB  - Human leukocyte antigen (HLA) allele and haplotype frequency distribution varies 
      widely between different ethnicities and geographical areas. Matching for HLA 
      alleles is essential for successful related and unrelated stem cell 
      transplantation. Among the Saudi population, data on HLA alleles and haplotypes 
      are limited. A cross-sectional study was performed on 28,927 bone marrow donors. 
      The most frequent HLA alleles were HLA-A(*)02:01:01G (20.2%), A(*)24:02:01G 
      (7.5%); B(*)51:01:01G (19.0%), B(*)50:01:01G (12.3%); C(*)06:02:01G (16.7%), 
      C(*)07:02:01G (12.2%); DRB1(*)07:01:01 (15.7%), DRB1(*)03:01:01G (13.3%); 
      DQB1(*)02:01:01G (29.9%), DQB1(*)03:02:01G (13.2%); and DPB1(*)04:01:01G (35.2%), 
      DPB1(*)02:01:02G (21.8%). The most frequent HLA-A~C~B~DRB1~DQB1 haplotypes were 
      A(*)02:01:01G~C(*)06:02:01G~B(*)50:01:01G~DRB1(*)07:01:01G~DQB1(*)02:01:01G 
      (1.9%) and 
      A(*)02:05:01G~C(*)06:02:01G~B(*)50:01:01G~DRB1(*)07:01:01G~DQB1(*)02:01:01G 
      (1.6%). The most frequent HLA-A~C~B~DRB1~DQB1~DPB1 haplotypes were 
      A(*)02:01:01G~C(*)15:02:01G~B(*)51:01:01G~DRB1(*)04:02~DQB1(*)03:02:01G~DPB1(*)04:01:0G 
      (1%) and 
      A(*)02:01:01G~C(*)07:02:01G~B(*)07:02:01G~DRB1(*)15:01:01G~DQB1(*)06:02:01G~ 
      DPB1(*)04:01:01G (0.9%). Based on these haplotype frequencies, we provide 
      forecasts for the fraction of patients with full matching and single mismatched 
      donors for 3 to 6 loci depending on the registry size. With one million donors, 
      about 50% of the patients would find an 8/8 match and 90% a 7/8 match. These data 
      are essential for registry planning, finding unrelated stem cell donors, 
      population genetic studies, and HLA disease associations.
CI  - Copyright (c) 2020 Jawdat, Uyar, Alaskar, Muller and Hajeer.
FAU - Jawdat, Dunia
AU  - Jawdat D
AD  - Saudi Stem Cells Donor Registry, King Abdullah International Medical Research 
      Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of 
      National Guard Health Affairs, Riyadh, Saudi Arabia.
FAU - Uyar, F Aytul
AU  - Uyar FA
AD  - Department of Physiology, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Alaskar, Ahmed
AU  - Alaskar A
AD  - Department of Oncology, King Abdulaziz Medical City - Ministry of National Guard 
      Health Affairs, King Abdullah International Medical Research Center, King Saud 
      bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
FAU - Muller, Carlheinz R
AU  - Muller CR
AD  - ZKRD Zentrales Knochenmarkspender-Register fur die Bundesrepublik Deutschland, 
      Ulm, Germany.
FAU - Hajeer, Ali
AU  - Hajeer A
AD  - Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City - 
      Ministry of National Guard Health Affairs, King Abdullah International Medical 
      Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 
      Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20201022
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - *Gene Frequency
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - HLA-DP beta-Chains/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Saudi Arabia
MH  - *Stem Cells
MH  - *Tissue Donors
PMC - PMC7643328
OTO - NOTNLM
OT  - Saudi Arabia
OT  - bone marrow registry
OT  - haplotype frequencies
OT  - population genetics
OT  - unrelated donors
EDAT- 2020/11/17 06:00
MHDA- 2021/04/29 06:00
PMCR- 2020/01/01
CRDT- 2020/11/16 08:47
PHST- 2020/03/22 00:00 [received]
PHST- 2020/08/18 00:00 [accepted]
PHST- 2020/11/16 08:47 [entrez]
PHST- 2020/11/17 06:00 [pubmed]
PHST- 2021/04/29 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.544768 [doi]
PST - epublish
SO  - Front Immunol. 2020 Oct 22;11:544768. doi: 10.3389/fimmu.2020.544768. eCollection 
      2020.