PMID- 33193383
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20211129
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - Low Hydrophobic Mismatch Scores Calculated for HLA-A/B/DR/DQ Loci Improve Kidney 
      Allograft Survival.
PG  - 580752
LID - 10.3389/fimmu.2020.580752 [doi]
LID - 580752
AB  - We evaluated the impact of human leukocyte antigen (HLA) disparity 
      (immunogenicity; IM) on long-term kidney allograft survival. The IM was 
      quantified based on physicochemical properties of the polymorphic linear 
      donor/recipient HLA amino acids (the Cambridge algorithm) as a hydrophobic, 
      electrostatic, amino acid mismatch scores (HMS\AMS\EMS) or eplet mismatch (EpMM) 
      load. High-resolution HLA-A/B/DRB1/DQB1 types were imputed to calculate HMS for 
      primary/re-transplant recipients of deceased donor transplants. The multiple Cox 
      regression showed the association of HMS with graft survival and other 
      confounders. The HMS integer 0-10 scale showed the most survival benefit between 
      HMS 0 and 3. The Kaplan-Meier analysis showed that: the HMS=0 group had 18.1-year 
      median graft survival, a 5-year benefit over HMS>0 group; HMS </= 3.0 had 16.7-year 
      graft survival, a 3.8-year better than HMS>3.0 group; and, HMS </= 7.8 had 
      14.3-year grafts survival, a 1.8-year improvement over HMS>7.8 group. 
      Stratification based on EMS, AMS or EpMM produced similar results. Additionally, 
      the importance of HLA-DR with/without -DQ IM for graft survival was shown. In our 
      simulation of 1,000 random donor/recipient pairs, 75% with HMS>3.0 were 
      re-matched into HMS </= 3.0 and the remaining 25% into HMS>/=7.8: after re-matching, 
      the 13.5 years graft survival would increase to 16.3 years. This approach matches 
      donors to recipients with low/medium IM donors thus preventing transplants with 
      high IM donors.
CI  - Copyright (c) 2020 Bekbolsynov, Mierzejewska, Borucka, Liwski, Greenshields, 
      Breidenbach, Gehring, Leonard-Murali, Khuder, Rees, Green and Stepkowski.
FAU - Bekbolsynov, Dulat
AU  - Bekbolsynov D
AD  - Department of Medical Microbiology and Immunology, University of Toledo, Toledo, 
      OH, United States.
FAU - Mierzejewska, Beata
AU  - Mierzejewska B
AD  - Department of Medical Microbiology and Immunology, University of Toledo, Toledo, 
      OH, United States.
FAU - Borucka, Jadwiga
AU  - Borucka J
AD  - Parexel International, Warsaw, Poland.
FAU - Liwski, Robert S
AU  - Liwski RS
AD  - Department of Pathology, Dalhousie University, Halifax, NS, Canada.
FAU - Greenshields, Anna L
AU  - Greenshields AL
AD  - Department of Pathology, Dalhousie University, Halifax, NS, Canada.
FAU - Breidenbach, Joshua
AU  - Breidenbach J
AD  - Department of Medical Microbiology and Immunology, University of Toledo, Toledo, 
      OH, United States.
FAU - Gehring, Bradley
AU  - Gehring B
AD  - Department of Medical Microbiology and Immunology, University of Toledo, Toledo, 
      OH, United States.
FAU - Leonard-Murali, Shravan
AU  - Leonard-Murali S
AD  - Department of Surgery, Henry Ford Hospital, Detroit, MI, United States.
FAU - Khuder, Sadik A
AU  - Khuder SA
AD  - Department of Medicine and Public Health, University of Toledo, Toledo, OH, 
      United States.
FAU - Rees, Michael
AU  - Rees M
AD  - Department of Medical Microbiology and Immunology, University of Toledo, Toledo, 
      OH, United States.
AD  - Department of Urology, University of Toledo College of Medicine, Toledo, OH, 
      United States.
AD  - The Alliance for Paired Donation, Maumee, OH, United States.
FAU - Green, Robert C 2nd
AU  - Green RC 2nd
AD  - Department of Computer Science, Bowling Green State University, Bowling Green, 
      OH, United States.
FAU - Stepkowski, Stanislaw M
AU  - Stepkowski SM
AD  - Department of Medical Microbiology and Immunology, University of Toledo, Toledo, 
      OH, United States.
LA  - eng
GR  - R01 LM013311/LM/NLM NIH HHS/United States
GR  - T32 CA113263/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20201029
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Amino Acids)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Allografts
MH  - Amino Acids/chemistry/genetics
MH  - Female
MH  - Genetic Loci
MH  - Graft Rejection/*immunology
MH  - Graft Survival
MH  - HLA-A Antigens/*genetics/metabolism
MH  - HLA-B Antigens/*genetics/metabolism
MH  - HLA-DQ Antigens/*genetics/metabolism
MH  - HLA-DR Antigens/*genetics/metabolism
MH  - Histocompatibility Testing
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Resource Allocation
MH  - Survival Analysis
MH  - Tissue Donors
MH  - Transplant Recipients
MH  - Young Adult
PMC - PMC7659444
OTO - NOTNLM
OT  - HLA mismatch
OT  - human leukocyte antigen (HLA)
OT  - immunogenicity
OT  - kidney allocation
OT  - kidney transplantation
OT  - transplant survival
EDAT- 2020/11/17 06:00
MHDA- 2021/06/22 06:00
PMCR- 2020/01/01
CRDT- 2020/11/16 08:47
PHST- 2020/07/06 00:00 [received]
PHST- 2020/10/02 00:00 [accepted]
PHST- 2020/11/16 08:47 [entrez]
PHST- 2020/11/17 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.580752 [doi]
PST - epublish
SO  - Front Immunol. 2020 Oct 29;11:580752. doi: 10.3389/fimmu.2020.580752. eCollection 
      2020.