PMID- 33193882
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201117
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 11
IP  - 24
DP  - 2020
TI  - Extranodal Extension as an Independent Prognostic factor in Laryngeal Squamous 
      Cell Carcinoma Patients.
PG  - 7196-7201
LID - 10.7150/jca.47700 [doi]
AB  - The presence of Lymph node metastasis with extranodal extension (ENE) is 
      considered to be an important adverse prognostic factor for survival in patients 
      with head and neck cancer. The aim of this study was to determine the prognostic 
      significance of ENE in patients with laryngeal squamous cell carcinoma (LSCC). 
      Three hundred and fifty-five patients with LSCC who underwent surgical resection 
      and neck dissection were included. The status of cervical lymph node was 
      classified into three groups: pathological negative nodal (pN-), pathological 
      positive nodal without ENE (ENE-), and pathological positive nodal with ENE 
      (ENE+). A total of 85 of 355 (23.9%) LSCC were pathological nodal positive, and 
      ENE was detected in 22/355 (6.2%) patients. ENE was associated with drinking 
      (p=0.005), T stage (p=0.000), tumor location (p=0.000), and differentiation 
      degree (p=0.000). The number of lymph node metastasis in ENE+ group was 
      associated with almost twice compared to ENE- group (p=0.005). The 5-year overall 
      survival rates for patients in the pN-, ENE-, and ENE+ groups were 86.4+/-2.6%, 
      75.9+/-6.3%, and 53.7+/-12.7%, respectively (p=0.000). After adjusting for 
      confounding variables, ENE+ was associated with more than five times the hazard 
      of death than pN- cases (p=0.000), and more than twice the hazard of death than 
      ENE- cases (p=0.036). Compared to N2-3/ENE- cases, N2-3/ENE+ cases had the 
      poorest survival rate (p=0.013). ENE+ was associated with worse outcomes compared 
      to pN - or ENE- status. ENE is an independent prognostic factor in LSCC, and 
      could be an indicator of the need for adjuvant treatment.
CI  - (c) The author(s).
FAU - Wang, Zhihai
AU  - Wang Z
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing 400016, China.
FAU - Zeng, Quan
AU  - Zeng Q
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing 400016, China.
FAU - Li, Yanshi
AU  - Li Y
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing 400016, China.
FAU - Lu, Tao
AU  - Lu T
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing 400016, China.
FAU - Liu, Chuan
AU  - Liu C
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing 400016, China.
FAU - Hu, Guohua
AU  - Hu G
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing 400016, China.
LA  - eng
PT  - Journal Article
DEP - 20201018
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC7646176
OTO - NOTNLM
OT  - extranodal extension
OT  - head and neck squamous cell carcinoma
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2020/11/17 06:00
MHDA- 2020/11/17 06:01
PMCR- 2020/01/01
CRDT- 2020/11/16 08:49
PHST- 2020/05/02 00:00 [received]
PHST- 2020/10/04 00:00 [accepted]
PHST- 2020/11/16 08:49 [entrez]
PHST- 2020/11/17 06:00 [pubmed]
PHST- 2020/11/17 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - jcav11p7196 [pii]
AID - 10.7150/jca.47700 [doi]
PST - epublish
SO  - J Cancer. 2020 Oct 18;11(24):7196-7201. doi: 10.7150/jca.47700. eCollection 2020.