PMID- 33195199
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201117
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 8
DP  - 2020
TI  - Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat 
      Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways.
PG  - 568894
LID - 10.3389/fcell.2020.568894 [doi]
LID - 568894
AB  - Tendinopathy is a common musculoskeletal disorder that mainly affects athletes 
      and people of older age. Tumor necrosis factor-alpha (TNF-alpha) plays an important role 
      in initiating tendinopathy. Tectorigenin, an extract component of Belam-canda 
      Chinesis, possesses anti-inflammatory and anti-apoptosis activity. The present 
      study was established to investigate the role of tectorigenin against the 
      pathogenetic effects of TNF-alpha on tendon-derived stem cells (TDSCs) in vivo and in 
      vitro. The findings indicated that TNF-alpha is able to induce TDSC inflammation, 
      apoptosis, and ossification, as well as activate nuclear factor-kappa B and 
      mitogen-activated protein kinase (MAPK). Furthermore, the results confirmed that 
      tectorigenin is able to inhibit the TNF-alpha-induced inflammation, apoptosis, and 
      ossification. Tectorigenin treatment decreases activation of NF-kappa B and MAPK 
      signaling in TDSCs. Tectorigenin ameliorates tendinopathy in the in vivo rat 
      model. Thus, these data reveal that tectorigenin can serve as a potential 
      treatment for tendinopathy.
CI  - Copyright (c) 2020 Moqbel, Xu, Chen, Xu, He, Wu, Ma, Ran, Wu and Xiong.
FAU - Moqbel, Safwat Adel Abdo
AU  - Moqbel SAA
AD  - Department of Orthopedic Surgery, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Xu, Kai
AU  - Xu K
AD  - Department of Orthopedic Surgery, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Chen, Zhonggai
AU  - Chen Z
AD  - Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying 
      Children's Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Xu, Langhai
AU  - Xu L
AD  - Department of Orthopedic Surgery, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - He, Yuezhe
AU  - He Y
AD  - Department of Orthopedic Surgery, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Wu, Zhipeng
AU  - Wu Z
AD  - Department of Orthopaedics, The First Affiliated Hospital of Zhejiang Chinese 
      Medical University, Hangzhou, China.
FAU - Ma, Chiyuan
AU  - Ma C
AD  - Department of Orthopedic Surgery, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Ran, Jisheng
AU  - Ran J
AD  - Department of Orthopedic Surgery, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Wu, Lidong
AU  - Wu L
AD  - Department of Orthopedic Surgery, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Xiong, Yan
AU  - Xiong Y
AD  - Department of Orthopedic Surgery, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20201022
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC7642480
OTO - NOTNLM
OT  - MAPK
OT  - TDSCs
OT  - TNF-alpha
OT  - apoptosis
OT  - inflammation
OT  - nuclear factor-kappa B pathway
OT  - ossification
OT  - tectorigenin
EDAT- 2020/11/17 06:00
MHDA- 2020/11/17 06:01
PMCR- 2020/01/01
CRDT- 2020/11/16 08:54
PHST- 2020/06/02 00:00 [received]
PHST- 2020/09/24 00:00 [accepted]
PHST- 2020/11/16 08:54 [entrez]
PHST- 2020/11/17 06:00 [pubmed]
PHST- 2020/11/17 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2020.568894 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2020 Oct 22;8:568894. doi: 10.3389/fcell.2020.568894. 
      eCollection 2020.