PMID- 33199982
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201118
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 20
IP  - 6
DP  - 2020 Dec
TI  - Radiological-prognostic correlation of diffusion tensor imaging in a mild 
      traumatic brain injury model.
PG  - 256
LID - 10.3892/etm.2020.9386 [doi]
LID - 256
AB  - Diffusion tensor imaging (DTI) parameters can detect changes in the brain 
      microstructure in mild traumatic brain injury (mTBI). Whether these parameter 
      changes can predict neural functional recovery after mTBI is still relatively 
      unknown. The present study aimed to investigate the radiological-prognostic 
      correlation between these radiological parameters and learning and memory 
      deficits using an in-house constructed rat model of mTBI. We established a rat 
      model of diffuse axonal injury (DAI) at different injury levels, followed by 
      magnetic resonance imaging at 6, 24, and 72 h, and 1, 2 weeks post injury, and 
      randomly selected the rats for analysis of histopathology and learning and memory 
      deficits. DTI parameters and beta-amyloid precursor protein (beta-APP) levels were 
      obtained to estimate the extent of brain injury and the correlation with the 
      times of crossing the safety platform as measured using a water maze test. The 
      results revealed that fractional anisotropy (FA) was sensitive to axonal 
      integrity. FA values of the corpus callosum in the injury groups decreased at all 
      time points post injury, except in the mild injury group, which recovered to 
      normal levels at 1 and 2 weeks post-injury. The neural function of the mild 
      injury group recovered to normal compared with the normal control group. FA 
      value, beta-APP of corpus callosum in different groups at 24 h post injury showed 
      obvious correlation with learning and memory deficits at the recovery stage 
      (r=0.881, r=-0.931). In conclusion, DTI can reflect varying injury states of DAI 
      over time with direct comparison to histopathology and could be used to predict 
      the neural functional recovery at the early stage post-injury in a rat model.
CI  - Copyright (c) 2020, Spandidos Publications.
FAU - Zhang, Yuting
AU  - Zhang Y
AD  - Department of Radiology, Children's Hospital of Chongqing Medical University, 
      Chongqing 400014, P.R. China.
AD  - Key Laboratory of Pediatrics in Chongqing, Chongqing 400014, P.R. China.
AD  - Ministry of Education Key Laboratory of Child Development and Disorders, 
      Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. 
      China.
FAU - Li, Lusheng
AU  - Li L
AD  - Key Laboratory of Pediatrics in Chongqing, Chongqing 400014, P.R. China.
AD  - Department of Neurosurgery, Children's Hospital of Chongqing Medical University, 
      Chongqing 400014, P.R. China.
FAU - He, Ling
AU  - He L
AD  - Department of Radiology, Children's Hospital of Chongqing Medical University, 
      Chongqing 400014, P.R. China.
AD  - Key Laboratory of Pediatrics in Chongqing, Chongqing 400014, P.R. China.
AD  - Ministry of Education Key Laboratory of Child Development and Disorders, 
      Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. 
      China.
LA  - eng
PT  - Journal Article
DEP - 20201027
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC7664597
OTO - NOTNLM
OT  - diffuse axonal injury
OT  - diffusion tensor imaging
OT  - mild traumatic brain injury
OT  - neural functional recovery
OT  - rat model
EDAT- 2020/11/18 06:00
MHDA- 2020/11/18 06:01
PMCR- 2020/10/27
CRDT- 2020/11/17 06:22
PHST- 2020/02/07 00:00 [received]
PHST- 2020/09/10 00:00 [accepted]
PHST- 2020/11/17 06:22 [entrez]
PHST- 2020/11/18 06:00 [pubmed]
PHST- 2020/11/18 06:01 [medline]
PHST- 2020/10/27 00:00 [pmc-release]
AID - ETM-0-0-09386 [pii]
AID - 10.3892/etm.2020.9386 [doi]
PST - ppublish
SO  - Exp Ther Med. 2020 Dec;20(6):256. doi: 10.3892/etm.2020.9386. Epub 2020 Oct 27.