PMID- 33200333
OWN - NLM
STAT- MEDLINE
DCOM- 20210721
LR  - 20210721
IS  - 1573-742X (Electronic)
IS  - 0929-5305 (Print)
IS  - 0929-5305 (Linking)
VI  - 52
IP  - 1
DP  - 2021 Jul
TI  - Clinical features of patients with acute coronary syndrome during the COVID-19 
      pandemic.
PG  - 95-104
LID - 10.1007/s11239-020-02340-z [doi]
AB  - Although a reduction in hospital admissions of acute coronary syndromes (ACS) 
      patients has been observed globally during the coronavirus disease 2019 
      (COVID-19) pandemic, clinical features of those patients have not been fully 
      investigated. The aim of the present analysis is to investigate the incidence, 
      clinical presentation, and outcomes of patients with ACS during the COVID-19 
      pandemic. We performed a retrospective analysis of consecutive patients who were 
      admitted for ACS at our institution between March 1 and April 20, 2020 and 
      compared with the equivalent period in 2019. Admissions for acute myocardial 
      infarction (AMI) reduced by 39.5% in 2020 compared with the equivalent period in 
      2019. Owing to the emergency medical services (EMS) of our region, all time 
      components of ST-elevated myocardial infarction care were similar during the 
      COVID-19 outbreak as compared with the previous year's dataset. Among the 106 ACS 
      patients in 2020, 7 patients tested positive for COVID-19. Higher incidence of 
      type 2 myocardial infarction (29% vs. 4%, p = 0.0497) and elevated D-dimer levels 
      (5650 mug/l [interquartile range (IQR) 1905-13,625 mug/l] vs. 400 mug/l [IQR 
      270-1050 mug/l], p = 0.02) were observed in COVID-19 patients. In sum, a 
      significant reduction in admission for AMI was observed during the COVID-19 
      pandemic. COVID-19 patients were characterized by elevated D-dimer levels on 
      admission, reflecting enhanced COVID-19 related thrombogenicity. The prehospital 
      evaluation by EMS may have played an important role for the timely 
      revascularization for STEMI patients.
CI  - (c) 2020. Springer Science+Business Media, LLC, part of Springer Nature.
FAU - Matsushita, Kensuke
AU  - Matsushita K
AUID- ORCID: 0000-0002-3722-2921
AD  - Pole d'Activite Medico-Chirurgicale Cardio-Vasculaire, Nouvel Hopital Civil, 
      Centre Hospitalier Universitaire, Universite de Strasbourg, 1 place de l'Hopital, 
      67091, Strasbourg cedex, France.
AD  - UMR1260 INSERM, Nanomedecine Regenerative, Faculte de Pharmacie, Universite de 
      Strasbourg, Illkirch, France.
FAU - Hess, Sebastien
AU  - Hess S
AD  - Pole d'Activite Medico-Chirurgicale Cardio-Vasculaire, Nouvel Hopital Civil, 
      Centre Hospitalier Universitaire, Universite de Strasbourg, 1 place de l'Hopital, 
      67091, Strasbourg cedex, France.
FAU - Marchandot, Benjamin
AU  - Marchandot B
AD  - Pole d'Activite Medico-Chirurgicale Cardio-Vasculaire, Nouvel Hopital Civil, 
      Centre Hospitalier Universitaire, Universite de Strasbourg, 1 place de l'Hopital, 
      67091, Strasbourg cedex, France.
FAU - Sato, Chisato
AU  - Sato C
AD  - Pole d'Activite Medico-Chirurgicale Cardio-Vasculaire, Nouvel Hopital Civil, 
      Centre Hospitalier Universitaire, Universite de Strasbourg, 1 place de l'Hopital, 
      67091, Strasbourg cedex, France.
AD  - UMR1260 INSERM, Nanomedecine Regenerative, Faculte de Pharmacie, Universite de 
      Strasbourg, Illkirch, France.
FAU - Truong, Dinh Phi
AU  - Truong DP
AD  - Pole d'Activite Medico-Chirurgicale Cardio-Vasculaire, Nouvel Hopital Civil, 
      Centre Hospitalier Universitaire, Universite de Strasbourg, 1 place de l'Hopital, 
      67091, Strasbourg cedex, France.
AD  - Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
FAU - Kim, Ngoc Thanh
AU  - Kim NT
AD  - Pole d'Activite Medico-Chirurgicale Cardio-Vasculaire, Nouvel Hopital Civil, 
      Centre Hospitalier Universitaire, Universite de Strasbourg, 1 place de l'Hopital, 
      67091, Strasbourg cedex, France.
AD  - Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
FAU - Weiss, Anne
AU  - Weiss A
AD  - Centre Hospitalier Universitaire, SAMU 67, Strasbourg, France.
FAU - Jesel, Laurence
AU  - Jesel L
AD  - Pole d'Activite Medico-Chirurgicale Cardio-Vasculaire, Nouvel Hopital Civil, 
      Centre Hospitalier Universitaire, Universite de Strasbourg, 1 place de l'Hopital, 
      67091, Strasbourg cedex, France.
AD  - UMR1260 INSERM, Nanomedecine Regenerative, Faculte de Pharmacie, Universite de 
      Strasbourg, Illkirch, France.
FAU - Ohlmann, Patrick
AU  - Ohlmann P
AD  - Pole d'Activite Medico-Chirurgicale Cardio-Vasculaire, Nouvel Hopital Civil, 
      Centre Hospitalier Universitaire, Universite de Strasbourg, 1 place de l'Hopital, 
      67091, Strasbourg cedex, France.
FAU - Morel, Olivier
AU  - Morel O
AD  - Pole d'Activite Medico-Chirurgicale Cardio-Vasculaire, Nouvel Hopital Civil, 
      Centre Hospitalier Universitaire, Universite de Strasbourg, 1 place de l'Hopital, 
      67091, Strasbourg cedex, France. olivier.morel@chru-strasbourg.fr.
AD  - UMR1260 INSERM, Nanomedecine Regenerative, Faculte de Pharmacie, Universite de 
      Strasbourg, Illkirch, France. olivier.morel@chru-strasbourg.fr.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20201116
PL  - Netherlands
TA  - J Thromb Thrombolysis
JT  - Journal of thrombosis and thrombolysis
JID - 9502018
RN  - 0 (Biomarkers)
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (fibrin fragment D)
SB  - IM
MH  - Acute Coronary Syndrome/diagnosis/epidemiology/*therapy
MH  - Aged
MH  - Aged, 80 and over
MH  - Angina, Unstable/diagnosis/epidemiology/*therapy
MH  - Biomarkers/blood
MH  - COVID-19/diagnosis/epidemiology/*therapy
MH  - Emergency Medical Services
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products/analysis
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Non-ST Elevated Myocardial Infarction/diagnosis/epidemiology/*therapy
MH  - Patient Admission
MH  - *Percutaneous Coronary Intervention
MH  - Retrospective Studies
MH  - ST Elevation Myocardial Infarction/diagnosis/epidemiology/*therapy
MH  - Time Factors
MH  - Time-to-Treatment
MH  - Treatment Outcome
PMC - PMC7668406
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Catheterization laboratory
OT  - Coronavirus disease 2019
OT  - Percutaneous coronary intervention
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/11/18 06:00
MHDA- 2021/07/22 06:00
PMCR- 2020/11/16
CRDT- 2020/11/17 06:25
PHST- 2020/11/09 00:00 [accepted]
PHST- 2020/11/18 06:00 [pubmed]
PHST- 2021/07/22 06:00 [medline]
PHST- 2020/11/17 06:25 [entrez]
PHST- 2020/11/16 00:00 [pmc-release]
AID - 10.1007/s11239-020-02340-z [pii]
AID - 2340 [pii]
AID - 10.1007/s11239-020-02340-z [doi]
PST - ppublish
SO  - J Thromb Thrombolysis. 2021 Jul;52(1):95-104. doi: 10.1007/s11239-020-02340-z. 
      Epub 2020 Nov 16.