PMID- 3320162
OWN - NLM
STAT- MEDLINE
DCOM- 19880202
LR  - 20190723
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 80
IP  - 6
DP  - 1987 Dec
TI  - The appearance of macrophage migration-inhibition factor in drug reactions.
PG  - 843-9
AB  - Drug-induced adverse reactions were suspected in 2030 patients with known 
      exposure to 243 different drugs. A modified direct macrophage 
      migration-inhibition factor (MIF) test for the different drugs was carried out on 
      blood samples from these patients. There was a positive MIF response toward one 
      or more of the suspected drugs in 53.4% of the patients as compared to 4.9% of 
      the control group; 155 of the 243 drugs elicited a positive MIF response. The 
      percentage of positive responses for each particular drug was not related to the 
      number of patients tested, reflecting the variability in specific immunogenicity 
      of the different drugs. The high percentage of positive MIF reactions in relation 
      to the clinical diagnosis suggests that this test can be a useful aid in the 
      detection of the offending drug in cases of suspected drug-induced reactions.
FAU - Livni, E
AU  - Livni E
AD  - Department of Dermatology, Beilinson Medical Center, Petah Tikva, Israel.
FAU - Halevy, S
AU  - Halevy S
FAU - Stahl, B
AU  - Stahl B
FAU - Joshua, H
AU  - Joshua H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Drug Combinations)
RN  - 0 (Macrophage Migration-Inhibitory Factors)
SB  - IM
MH  - Animals
MH  - Cell Migration Inhibition
MH  - Drug Combinations
MH  - Drug Hypersensitivity/*diagnosis/immunology
MH  - Guinea Pigs
MH  - Humans
MH  - Immunity, Cellular/drug effects
MH  - Macrophage Migration-Inhibitory Factors/*blood
EDAT- 1987/12/01 00:00
MHDA- 1987/12/01 00:01
CRDT- 1987/12/01 00:00
PHST- 1987/12/01 00:00 [pubmed]
PHST- 1987/12/01 00:01 [medline]
PHST- 1987/12/01 00:00 [entrez]
AID - S0091-6749(87)80275-0 [pii]
AID - 10.1016/s0091-6749(87)80275-0 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 1987 Dec;80(6):843-9. doi: 10.1016/s0091-6749(87)80275-0.