PMID- 33202817
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201201
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 9
IP  - 11
DP  - 2020 Nov 13
TI  - Effects of Rutin on Wound Healing in Hyperglycemic Rats.
LID - 10.3390/antiox9111122 [doi]
LID - 1122
AB  - Long-term poor glycemic control negatively affects macrovascular and 
      microvascular diseases, as well as wound restoration. Buckwheat is a good source 
      of rutin (quercetin-3-O-rutoside) and has benefits in regulating blood sugar. 
      This study was to evaluate the antioxidant and anti-inflammatory effects of rutin 
      on wound healing in streptozotocin-induced hyperglycemic rats. Eighteen male 
      Wistar rats were randomly divided into three groups: normal (NDM), hyperglycemic 
      (DM), and hyperglycemic with rutin (DMR). After induction of hyperglycemia for 2 
      days, a 15 x 15 mm wound was induced on the back of each rat. Intraperitoneal 
      injection of rutin significantly ameliorated diabetes-induced body weight loss 
      and improved metabolic dysfunctions of hyperglycemic rats. Based on appearance 
      and histopathological staining, rutin promotes wound healing and inhibits 
      production of inflammatory cells. The immunoblotting data indicated that rutin 
      promotes production of antioxidant enzymes induced by nuclear factor erythroid 
      2-related factor 2 (NRF2), inhibits the expression of matrix metalloproteinases 
      (MMPs) regulated by NF-kappaB, and decreases the expression of vascular endothelial 
      growth factor (VEGF). It also promotes the expression of neurogenic-related 
      protein (UCH-L1). The aforementioned results indicated that rutin reduces 
      oxidative stress and inflammatory response in hyperglycemic rats, promoting wound 
      healing and subsequently reducing the risk of wound ulcers.
FAU - Chen, Li-You
AU  - Chen LY
AD  - Department of Anatomy, School of Medicine, College of Medicine, Chung Shan 
      Medical University, Taichung City 40201, Taiwan.
AD  - Department of Medical Education, Chung Shan Medical University Hospital, Taichung 
      City 40201, Taiwan.
FAU - Huang, Chien-Ning
AU  - Huang CN
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism, Chung 
      Shan Medical University Hospital, Taichung City 40201, Taiwan.
AD  - Institute of Medicine, College of Medicine, Chung Shan Medical University, 
      Taichung City 40201, Taiwan.
FAU - Liao, Chih-Kai
AU  - Liao CK
AD  - Department of Anatomy, School of Medicine, College of Medicine, Chung Shan 
      Medical University, Taichung City 40201, Taiwan.
AD  - Department of Medical Education, Chung Shan Medical University Hospital, Taichung 
      City 40201, Taiwan.
FAU - Chang, Hung-Ming
AU  - Chang HM
AD  - Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, 
      Taipei Medical University, Taipei City 40201, Taiwan.
FAU - Kuan, Yu-Hsiang
AU  - Kuan YH
AUID- ORCID: 0000-0002-8991-6394
AD  - Department of Pharmacology, School of Medicine, Chung Shan Medical University, 
      Taichung City 40201, Taiwan.
AD  - Department of Pharmacy, Chung Shan Medical University Hospital, Taichung City 
      40201, Taiwan.
FAU - Tseng, To-Jung
AU  - Tseng TJ
AD  - Department of Anatomy, School of Medicine, College of Medicine, Chung Shan 
      Medical University, Taichung City 40201, Taiwan.
AD  - Department of Medical Education, Chung Shan Medical University Hospital, Taichung 
      City 40201, Taiwan.
FAU - Yen, Kai-Jung
AU  - Yen KJ
AD  - Department of Anatomy, School of Medicine, College of Medicine, Chung Shan 
      Medical University, Taichung City 40201, Taiwan.
FAU - Yang, Kai-Lin
AU  - Yang KL
AD  - Department of Anatomy, School of Medicine, College of Medicine, Chung Shan 
      Medical University, Taichung City 40201, Taiwan.
FAU - Lin, Hsing-Chun
AU  - Lin HC
AUID- ORCID: 0000-0002-9365-4745
AD  - Department of Nutrition, Chung Shan Medical University, Taichung City 40201, 
      Taiwan.
AD  - Department of Nutrition, Chung Shan Medical University Hospital, Taichung City 
      40201, Taiwan.
LA  - eng
GR  - CSH-2020-C-028/Chung Shan Medical University Hospital/
PT  - Journal Article
DEP - 20201113
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC7696622
OTO - NOTNLM
OT  - anti-inflammatory
OT  - antioxidant
OT  - hyperglycemia
OT  - rutin
OT  - wound healing
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/19 06:00
MHDA- 2020/11/19 06:01
PMCR- 2020/11/13
CRDT- 2020/11/18 01:01
PHST- 2020/10/06 00:00 [received]
PHST- 2020/11/05 00:00 [revised]
PHST- 2020/11/10 00:00 [accepted]
PHST- 2020/11/18 01:01 [entrez]
PHST- 2020/11/19 06:00 [pubmed]
PHST- 2020/11/19 06:01 [medline]
PHST- 2020/11/13 00:00 [pmc-release]
AID - antiox9111122 [pii]
AID - antioxidants-09-01122 [pii]
AID - 10.3390/antiox9111122 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2020 Nov 13;9(11):1122. doi: 10.3390/antiox9111122.