PMID- 33204132
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201119
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 13
DP  - 2020
TI  - Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in 
      Type-2 Diabetes Mellitus: A Therapeutic Perspective.
PG  - 4261-4272
LID - 10.2147/DMSO.S279104 [doi]
AB  - Patients with type-2 diabetes mellitus (T2DM) display chronic low-grade 
      inflammation induced by activation of the innate immune system. Toll-like 
      receptor (TLR)4 is a pattern recognition receptor that plays a vital part in 
      activation of the innate immune system. Results from animal and 
      computer-simulation studies have demonstrated that targeting TLR4 to block the 
      TLR4-nuclear factor-kappa B (NF-kappaB) pathway reduces the inflammatory response and 
      complications associated with T2DM. Therefore, TLR4-targeted therapy has broad 
      prospects. Here, we reviewed the role of TLR4 in inflammation during chronic 
      hyperglycemia in T2DM and its therapeutic prospects.
CI  - (c) 2020 Wang et al.
FAU - Wang, Zhaoping
AU  - Wang Z
AD  - The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of 
      Gerontology, Beijing, People's Republic of China.
FAU - Ni, Xiaolin
AU  - Ni X
AD  - The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of 
      Gerontology, Beijing, People's Republic of China.
AD  - Graduate School of Peking Union Medical College, Chinese Academy of Medical 
      Sciences, Beijing, People's Republic of China.
FAU - Zhang, Li
AU  - Zhang L
AD  - The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of 
      Gerontology, Beijing, People's Republic of China.
FAU - Sun, Liang
AU  - Sun L
AD  - The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of 
      Gerontology, Beijing, People's Republic of China.
FAU - Zhu, Xiaoquan
AU  - Zhu X
AD  - The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of 
      Gerontology, Beijing, People's Republic of China.
FAU - Zhou, Qi
AU  - Zhou Q
AD  - The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of 
      Gerontology, Beijing, People's Republic of China.
FAU - Yang, Ze
AU  - Yang Z
AD  - The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of 
      Gerontology, Beijing, People's Republic of China.
FAU - Yuan, Huiping
AU  - Yuan H
AD  - The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of 
      Gerontology, Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201110
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC7666984
OTO - NOTNLM
OT  - T2DM
OT  - TLR4
OT  - TLR4 treatment
OT  - TLRS
OT  - inflammation
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/11/19 06:00
MHDA- 2020/11/19 06:01
PMCR- 2020/11/10
CRDT- 2020/11/18 05:57
PHST- 2020/08/27 00:00 [received]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2020/11/18 05:57 [entrez]
PHST- 2020/11/19 06:00 [pubmed]
PHST- 2020/11/19 06:01 [medline]
PHST- 2020/11/10 00:00 [pmc-release]
AID - 279104 [pii]
AID - 10.2147/DMSO.S279104 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2020 Nov 10;13:4261-4272. doi: 10.2147/DMSO.S279104. 
      eCollection 2020.