PMID- 33207006
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20210917
IS  - 1939-165X (Electronic)
IS  - 0275-6382 (Linking)
VI  - 49
IP  - 4
DP  - 2020 Dec
TI  - Establishment of a reference interval for a novel viscoelastic coagulometer and 
      comparison with thromboelastography in healthy cats.
PG  - 660-664
LID - 10.1111/vcp.12916 [doi]
AB  - BACKGROUND: Viscoelastic analysis provides information on the dynamics and 
      strength of clot formation as well as clot stability. A novel point-of-care 
      viscoelastic test (Viscoelastic Coagulation Monitor Vet, VCM Vet) could be more 
      cost-effective, simpler to use, and more portable than thromboelastography (TEG). 
      OBJECTIVES: The primary aim of this study was to establish a feline reference 
      interval (RI) for the VCM Vet. A secondary aim was to compare VCM Vet analysis 
      with TEG in healthy cats. METHODS: Fifty-six healthy cats were enrolled in this 
      study. Linear regression was completed to determine whether age and CBC 
      parameters were associated with the VCM Vet parameters and if TEG parameters were 
      correlated with VCM Vet data. Statistical significance was set at P < .05. 
      RESULTS: Fifty-three VCM Vet tracings were used to determine RIs for healthy 
      cats. The determined RIs were: clot time (CT) 104-438 seconds; clot formation 
      time (CFT) 104.5-488 seconds; alpha angle (AA) 30.5 degrees -70 degrees ; a10 13.8-32.7 VCM 
      units; a20 19.2-40.1 VCM units; maximum clot formation (MCF) 22.5-44.8 VCM units; 
      Lysis Index 30 (Li30) 92.9%-100.9%; and Lysis Index 45 (Li45) 92%-100%. Linear 
      regression identified a strong positive correlation between the CT and R-time 
      measured using the VCM Vet and TEG methods, respectively; no other parameters 
      were correlated. CONCLUSIONS: The use of VCM Vet is feasible in cats, and we 
      determined the first described feline RIs for this test. In general, the VCM Vet 
      data did not correlate with TEG in healthy cats.
CI  - (c) 2020 American Society for Veterinary Clinical Pathology.
FAU - Rosati, Tommaso
AU  - Rosati T
AUID- ORCID: 0000-0002-8993-5122
AD  - William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary 
      Medicine, University of California, Davis, Davis, USA.
FAU - Jandrey, Karl E
AU  - Jandrey KE
AUID- ORCID: 0000-0002-2730-7817
AD  - Department of Surgical and Radiological Sciences, School of Veterinary Medicine, 
      University of California, Davis, Davis, USA.
FAU - Burges, Julie W
AU  - Burges JW
AD  - William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary 
      Medicine, University of California, Davis, Davis, USA.
FAU - Kent, Michael S
AU  - Kent MS
AUID- ORCID: 0000-0002-7703-7720
AD  - Department of Surgical and Radiological Sciences, School of Veterinary Medicine, 
      University of California, Davis, Davis, USA.
LA  - eng
PT  - Journal Article
DEP - 20201118
PL  - United States
TA  - Vet Clin Pathol
JT  - Veterinary clinical pathology
JID - 9880575
SB  - IM
MH  - Animals
MH  - Blood Coagulation
MH  - Blood Coagulation Tests/veterinary
MH  - *Cat Diseases
MH  - Cats
MH  - Reference Values
MH  - Thrombelastography/veterinary
MH  - *Thrombosis/veterinary
OTO - NOTNLM
OT  - VCM Vet
OT  - coagulation
OT  - feline
OT  - point-of-care
EDAT- 2020/11/19 06:00
MHDA- 2021/09/18 06:00
CRDT- 2020/11/18 17:10
PHST- 2019/08/06 00:00 [received]
PHST- 2020/02/29 00:00 [revised]
PHST- 2020/03/26 00:00 [accepted]
PHST- 2020/11/19 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/11/18 17:10 [entrez]
AID - 10.1111/vcp.12916 [doi]
PST - ppublish
SO  - Vet Clin Pathol. 2020 Dec;49(4):660-664. doi: 10.1111/vcp.12916. Epub 2020 Nov 
      18.