PMID- 33207756
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20210630
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 9
IP  - 11
DP  - 2020 Nov 16
TI  - Stem Cell Metabolism: Powering Cell-Based Therapeutics.
LID - 10.3390/cells9112490 [doi]
LID - 2490
AB  - Cell-based therapeutics for cardiac repair have been extensively used during the 
      last decade. Preclinical studies have demonstrated the effectiveness of 
      adoptively transferred stem cells for enhancement of cardiac function. 
      Nevertheless, several cell-based clinical trials have provided largely 
      underwhelming outcomes. A major limitation is the lack of survival in the harsh 
      cardiac milieu as only less than 1% donated cells survive. Recent efforts have 
      focused on enhancing cell-based therapeutics and understanding the biology of 
      stem cells and their response to environmental changes. Stem cell metabolism has 
      recently emerged as a critical determinant of cellular processes and is uniquely 
      adapted to support proliferation, stemness, and commitment. Metabolic signaling 
      pathways are remarkably sensitive to different environmental signals with a 
      profound effect on cell survival after adoptive transfer. Stem cells mainly 
      generate energy through glycolysis while maintaining low oxidative 
      phosphorylation (OxPhos), providing metabolites for biosynthesis of 
      macromolecules. During commitment, there is a shift in cellular metabolism, which 
      alters cell function. Reprogramming stem cell metabolism may represent an 
      attractive strategy to enhance stem cell therapy for cardiac repair. This review 
      summarizes the current literature on how metabolism drives stem cell function and 
      how this knowledge can be applied to improve cell-based therapeutics for cardiac 
      repair.
FAU - Rigaud, Vagner O C
AU  - Rigaud VOC
AUID- ORCID: 0000-0002-1194-9380
AD  - Center for Metabolic Disease Research (CMDR), Lewis Katz School of Medicine, 
      Temple University, Philadelphia, PA 19140, USA.
FAU - Hoy, Robert
AU  - Hoy R
AUID- ORCID: 0000-0001-9000-5793
AD  - Center for Metabolic Disease Research (CMDR), Lewis Katz School of Medicine, 
      Temple University, Philadelphia, PA 19140, USA.
FAU - Mohsin, Sadia
AU  - Mohsin S
AUID- ORCID: 0000-0002-2106-1094
AD  - Cardiovascular Research Center (CVRC), Lewis Katz School of Medicine, Temple 
      University, Philadelphia, PA 19140, USA.
FAU - Khan, Mohsin
AU  - Khan M
AUID- ORCID: 0000-0001-7007-1048
AD  - Center for Metabolic Disease Research (CMDR), Lewis Katz School of Medicine, 
      Temple University, Philadelphia, PA 19140, USA.
AD  - Department of Physiology, Lewis Katz School of Medicine, Temple University, 
      Philadelphia, PA 19140, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201116
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
SB  - IM
MH  - Cell Proliferation/physiology
MH  - Energy Metabolism/*physiology
MH  - Glycolysis/*physiology
MH  - Humans
MH  - Oxidative Phosphorylation
MH  - *Stem Cell Transplantation/methods
MH  - Stem Cells/*cytology
PMC - PMC7696341
OTO - NOTNLM
OT  - cell therapy
OT  - metabolic reprogramming
OT  - metabolism
OT  - myocardial injury
OT  - stem cells
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/20 06:00
MHDA- 2021/07/01 06:00
PMCR- 2020/11/01
CRDT- 2020/11/19 01:02
PHST- 2020/10/09 00:00 [received]
PHST- 2020/11/11 00:00 [revised]
PHST- 2020/11/12 00:00 [accepted]
PHST- 2020/11/19 01:02 [entrez]
PHST- 2020/11/20 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - cells9112490 [pii]
AID - cells-09-02490 [pii]
AID - 10.3390/cells9112490 [doi]
PST - epublish
SO  - Cells. 2020 Nov 16;9(11):2490. doi: 10.3390/cells9112490.