PMID- 33210591
OWN - NLM
STAT- MEDLINE
DCOM- 20210112
LR  - 20210112
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 36
IP  - 11
DP  - 2020 Nov
TI  - [Exposure of acute severe air pollution promotes inflammatory cell infiltration 
      and increases the levels of proinflammatory cytokines and chemokines in lung 
      tissues of rats].
PG  - 977-982
AB  - Objective To observe the effect of acute severe air pollution exposure on 
      cytokines and chemokines in lung tissues of rats and explore its significance. 
      Methods During the period of severe air pollution in Beijing from December 17 to 
      22, 2016, rats were exposed to air pollution for 6 days, and then sacrificed on 
      the 7th day. Lung tissues were taken and their histological changes were observed 
      by HE staining. The levels of 22 cytokines/chemokines in the lung tissue 
      homogenate supernatant were detected by liquid chip method. Results Compared with 
      the control group, the lung tissues of the rats in the air pollution exposure 
      group were characterized by widened alveolar septum, inflammatory cell 
      infiltration and vascular bleeding. Chemokines eotaxin, monocyte chemoattractant 
      protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2), regulated on 
      activation, normal T cell expressed and secreted factor (RANTES), and 
      proinflammatory cytokines interleukin 1beta (IL-1beta), IL-17, IL-18, tumor necrosis 
      factor alpha (TNF-alpha) in the supernatant of lung homogenate of rats in the air 
      pollution exposure group significantly increased. But anti-inflammatory IL-10 
      significantly decreased. Th1 cytokines IL-2 and interferon-gamma (IFN-gamma) did not 
      change, and Th2 cytokines IL-5 increased by 1.65 times and IL-10 decreased by 
      0.82 times. Conclusion Acute severe air pollution exposure can lead to 
      inflammatory response in lung tissues of rats. The secretion of chemokines 
      eotaxin, MCP-1, MIP-2, RANTES and proinflammatory cytokines IL-1beta, IL-17, IL-18, 
      TNF-alpha are promoted in this process. The infiltrated T cells in lung tissues are 
      dominated by Th2 cells.
FAU - Si, Shaoyan
AU  - Si S
AD  - Laboratory of Basic Medical Research, Medical Center of PLA Strategic Support 
      Force, Beijing 100101, China.
FAU - Song, Shujun
AU  - Song S
AD  - Laboratory of Basic Medical Research, Medical Center of PLA Strategic Support 
      Force, Beijing 100101, China.
FAU - Qin, Yaya
AU  - Qin Y
AD  - Laboratory of Basic Medical Research, Medical Center of PLA Strategic Support 
      Force, Beijing 100101, China.
FAU - Wu, Yingying
AU  - Wu Y
AD  - Laboratory of Basic Medical Research, Medical Center of PLA Strategic Support 
      Force, Beijing 100101, China.
FAU - Xu, Bingxin
AU  - Xu B
AD  - Laboratory of Basic Medical Research, Medical Center of PLA Strategic Support 
      Force, Beijing 100101, China.
FAU - Wang, Gang
AU  - Wang G
AD  - Department of Otorhinolaryngology, Medical Center of PLA Strategic Support Force, 
      Beijing 100101, China.
FAU - Zhu, Minli
AU  - Zhu M
AD  - Department of Respiratory Medicine, State Environmental Protection Key Laboratory 
      of Environmental Sense Organ Stress and Health, Medical Center of PLA Strategic 
      Support Force, Beijing 100101, China.
FAU - Wu, Wei
AU  - Wu W
AD  - Department of Otorhinolaryngology, Medical Center of PLA Strategic Support Force, 
      Beijing 100101, China. *Corresponding author, E-mail: yf2000412@163.com.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (Air Pollutants)
RN  - 0 (Chemokine CCL11)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
SB  - IM
MH  - *Air Pollutants/toxicity
MH  - Animals
MH  - Chemokine CCL11
MH  - Chemokines/immunology
MH  - *Cytokines/immunology
MH  - *Environmental Exposure/adverse effects
MH  - *Lung/drug effects/immunology
MH  - Rats
MH  - Th2 Cells/immunology
EDAT- 2020/11/20 06:00
MHDA- 2021/01/13 06:00
CRDT- 2020/11/19 08:47
PHST- 2020/11/19 08:47 [entrez]
PHST- 2020/11/20 06:00 [pubmed]
PHST- 2021/01/13 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2020 Nov;36(11):977-982.