PMID- 33210746
OWN - NLM
STAT- MEDLINE
DCOM- 20210219
LR  - 20210219
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Linking)
VI  - 89
IP  - 2
DP  - 2021 Feb
TI  - Silent New Brain MRI Lesions in Children with MOG-Antibody Associated Disease.
PG  - 408-413
LID - 10.1002/ana.25957 [doi]
AB  - Anti-myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) antibodies 
      are associated clinically with either a monophasic or relapsing disease course. 
      We investigated the frequency and clinical importance of acquired asymptomatic 
      brain magnetic resonance imaging (MRI) lesions in a prospective incident cohort 
      of 74 MOG-IgG positive children with serial MRI scans over a median of 5 years 
      from presentation. Silent new lesions were detected in 14% of MOG-IgG positive 
      participants, most commonly within the first months post-onset, with a positive 
      predictive value for clinically relapsing disease of only 20%. Detection of 
      asymptomatic lesions alone need not prompt initiation of chronic immunotherapy. 
      ANN NEUROL 2021;89:408-413.
CI  - (c) 2020 American Neurological Association.
FAU - Fadda, Giulia
AU  - Fadda G
AUID- ORCID: 0000-0001-9658-815X
AD  - Center for Neuroinflammation and Neurotherapeutics, and Multiple Sclerosis 
      Division, Department of Neurology, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, PA.
FAU - Banwell, Brenda
AU  - Banwell B
AD  - Center for Neuroinflammation and Neurotherapeutics, and Multiple Sclerosis 
      Division, Department of Neurology, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, PA.
AD  - Division of Child Neurology, Department of Neurology, The Children's Hospital of 
      Philadelphia, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA.
FAU - Waters, Patrick
AU  - Waters P
AUID- ORCID: 0000-0003-4142-2667
AD  - Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, 
      University of Oxford, Oxford, UK.
FAU - Marrie, Ruth A
AU  - Marrie RA
AD  - Departments of Internal Medicine and Community Health Sciences, Max Rady College 
      of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, 
      MB, Canada.
FAU - Yeh, E Ann
AU  - Yeh EA
AD  - Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
FAU - O'Mahony, Julia
AU  - O'Mahony J
AD  - Institute of Health Policy, Management and Evaluation, the University of Toronto, 
      The Hospital for Sick Children, Toronto, ON, Canada.
FAU - Arnold, Douglas A
AU  - Arnold DA
AUID- ORCID: 0000-0003-4266-0106
AD  - Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
FAU - Bar-Or, Amit
AU  - Bar-Or A
AD  - Center for Neuroinflammation and Neurotherapeutics, and Multiple Sclerosis 
      Division, Department of Neurology, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, PA.
AD  - Division of Child Neurology, Department of Neurology, The Children's Hospital of 
      Philadelphia, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA.
AD  - Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
CN  - Canadian Pediatric Demyelinating Disease Network
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201130
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Autoantibodies)
RN  - 0 (Glucocorticoids)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
RN  - 0 (Oligoclonal Bands)
SB  - IM
MH  - Adolescent
MH  - *Asymptomatic Diseases
MH  - Autoantibodies/*immunology
MH  - Brain/*diagnostic imaging/physiopathology
MH  - Child
MH  - Demyelinating Autoimmune Diseases, CNS/*diagnostic 
      imaging/immunology/physiopathology/therapy
MH  - Encephalomyelitis, Acute Disseminated/*diagnostic 
      imaging/immunology/physiopathology/therapy
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Immunoglobulin G
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Immunologic Factors/therapeutic use
MH  - Immunotherapy
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Multiple Sclerosis/*diagnostic imaging/immunology/physiopathology/therapy
MH  - Myelin-Oligodendrocyte Glycoprotein/*immunology
MH  - Oligoclonal Bands/cerebrospinal fluid
MH  - Plasma Exchange
MH  - Recurrence
EDAT- 2020/11/20 06:00
MHDA- 2021/02/20 06:00
CRDT- 2020/11/19 08:47
PHST- 2020/08/11 00:00 [received]
PHST- 2020/11/11 00:00 [revised]
PHST- 2020/11/12 00:00 [accepted]
PHST- 2020/11/20 06:00 [pubmed]
PHST- 2021/02/20 06:00 [medline]
PHST- 2020/11/19 08:47 [entrez]
AID - 10.1002/ana.25957 [doi]
PST - ppublish
SO  - Ann Neurol. 2021 Feb;89(2):408-413. doi: 10.1002/ana.25957. Epub 2020 Nov 30.