PMID- 33212128
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 192
DP  - 2021 Jan
TI  - Potential obesogenic effect of a complex contaminant mixture on Cree First 
      Nations adults of Northern Quebec, Canada.
PG  - 110478
LID - S0013-9351(20)31375-X [pii]
LID - 10.1016/j.envres.2020.110478 [doi]
AB  - BACKGROUND: Obesity incidence and prevalence is of increasing concern in First 
      Nations communities around Canada. In addition to diet and physical activity, 
      environmental pollutants have been suggested as a potential contributory factor 
      to obesity associated morbidity. Owing to the exposure of Cree First Nations 
      people to various persistent organic pollutants (POPs) and toxic metals, it is 
      important to examine the association between obesity in these communities, and 
      contaminant body burdens. OBJECTIVE: To determine whether selected morphometry 
      measures (body mass index [BMI], waist circumference [WC] and body fat 
      percentage) are associated with body burdens of 10 POPs and toxic metals. 
      METHODS: Using data from the Nituuchischaayihtitaau Aschii Multi-community 
      Environment-and-Health study in the eastern James Bay (Eeyou Istchee) Cree 
      communities, this cross-sectional study examined morphometric and contaminant 
      measures of 695 eligible participants. Sex stratified principal component 
      analysis was conducted on blood plasma concentrations of 10 POPs and toxic 
      metals. BMI, WC, body fat percent, and resultant contaminant components were used 
      to create generalized linear models, and adjusted for covariates (age, total 
      lipids, smoking, and n-3 fatty acids). RESULTS: Two principal components (PCs; 
      PC-1 and PC-2) were extracted for both males and females. For females, PC-1 
      explained 73.3% and PC-2 explained 10.5%, and for males, PC-1 explained 71.6% and 
      PC-2 explained 11.2% of the variance in contaminant burden. For both sexes, PC-1 
      loaded highly for polychlorinated biphenyl (PCB) congeners, organochlorine 
      pesticides and, to a lesser extent, mercury and lead. PC-2 loaded highly for 
      cadmium for females, and cadmium and lead for males. After adjusting for 
      covariates, the generalized linear model showed that PC-2 was significantly and 
      negatively associated with BMI, body fat percent, and WC in males and females. 
      CONCLUSIONS: Our cross-sectional analysis indicates a negative association 
      between cadmium with various obesity measures in both males and females. Null 
      associations were found between PCBs and organochlorine pesticides and 
      morphometry.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Akbar, Lamia
AU  - Akbar L
AD  - Department of Physical and Environmental Sciences, University of Toronto, M1C 
      1A4, Toronto, Ontario, Canada. Electronic address: lamia.akbar@mail.utoronto.ca.
FAU - Zuk, Aleksandra M
AU  - Zuk AM
AD  - Department of Physical and Environmental Sciences, University of Toronto, M1C 
      1A4, Toronto, Ontario, Canada; School of Nursing, Faculty of Health Sciences, 
      Queen's University, Kingston, K7L 3N6, Ontario, Canada. Electronic address: 
      aleksandra.zuk@utoronto.ca.
FAU - Martin, Ian D
AU  - Martin ID
AD  - Department of Physical and Environmental Sciences, University of Toronto, M1C 
      1A4, Toronto, Ontario, Canada. Electronic address: ianmartin@mac.com.
FAU - Liberda, Eric N
AU  - Liberda EN
AD  - School of Occupational and Public Health, Ryerson University, Toronto, M5B 2K9, 
      Ontario, Canada. Electronic address: eric.liberda@ryerson.ca.
FAU - Tsuji, Leonard J S
AU  - Tsuji LJS
AD  - Department of Physical and Environmental Sciences, University of Toronto, M1C 
      1A4, Toronto, Ontario, Canada. Electronic address: leonard.tsuji@utoronto.ca.
LA  - eng
GR  - 156396/CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201116
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Canada
MH  - Cross-Sectional Studies
MH  - *Environmental Pollutants/analysis/toxicity
MH  - Female
MH  - Humans
MH  - Male
MH  - *Polychlorinated Biphenyls/toxicity
MH  - Quebec/epidemiology
OTO - NOTNLM
OT  - Cree first nations
OT  - Obesogens
OT  - Organochlorines
OT  - PCBs
OT  - Toxic metals
EDAT- 2020/11/20 06:00
MHDA- 2021/04/20 06:00
CRDT- 2020/11/19 20:08
PHST- 2020/08/15 00:00 [received]
PHST- 2020/11/02 00:00 [revised]
PHST- 2020/11/11 00:00 [accepted]
PHST- 2020/11/20 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2020/11/19 20:08 [entrez]
AID - S0013-9351(20)31375-X [pii]
AID - 10.1016/j.envres.2020.110478 [doi]
PST - ppublish
SO  - Environ Res. 2021 Jan;192:110478. doi: 10.1016/j.envres.2020.110478. Epub 2020 
      Nov 16.